<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:f6ec4fab-a519-489e-b421-6c7ee3322750,g:f7084e6e-47c2-4faa-aed0-8ba33c516e4f-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.biocryst.com/role/Cover" xlink:type="simple" xlink:href="bcrx-20220930.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_e24c305e-bb30-45b1-a578-7294aa0f5576" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_DocumentType_e24c305e-bb30-45b1-a578-7294aa0f5576" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_4972f23a-7735-452d-943d-ffe3e5b56816" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_DocumentQuarterlyReport_4972f23a-7735-452d-943d-ffe3e5b56816" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_3316bddf-f583-4815-8b2a-a4070e28a7dc" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_DocumentPeriodEndDate_3316bddf-f583-4815-8b2a-a4070e28a7dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_0e5dcb40-9952-4330-8ea4-2032a6756202" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_DocumentTransitionReport_0e5dcb40-9952-4330-8ea4-2032a6756202" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_6ada14ec-c53c-4b67-af8f-2f2e67854e3c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityFileNumber_6ada14ec-c53c-4b67-af8f-2f2e67854e3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_639c7a53-528e-4e63-af7a-ea923c868df5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityRegistrantName_639c7a53-528e-4e63-af7a-ea923c868df5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_5c650378-4138-4d86-95df-ea577d13a34f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityIncorporationStateCountryCode_5c650378-4138-4d86-95df-ea577d13a34f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_4b99cf79-c1c6-4192-bc2a-5ae377475cf7" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityTaxIdentificationNumber_4b99cf79-c1c6-4192-bc2a-5ae377475cf7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_7988d32d-b7e4-4ecb-bf3b-eed28043576b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityAddressAddressLine1_7988d32d-b7e4-4ecb-bf3b-eed28043576b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_5f926871-7665-442f-ad45-9f72d9c7fd35" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityAddressCityOrTown_5f926871-7665-442f-ad45-9f72d9c7fd35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_c90611b3-69bf-47f0-81b9-a5803388043a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityAddressStateOrProvince_c90611b3-69bf-47f0-81b9-a5803388043a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_c188b8ca-9bfd-4fbe-9d24-9d84c6ee3437" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityAddressPostalZipCode_c188b8ca-9bfd-4fbe-9d24-9d84c6ee3437" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_9d18d0b0-698e-43d4-9122-79a9aaf181f5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_CityAreaCode_9d18d0b0-698e-43d4-9122-79a9aaf181f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_e26d07fd-693e-496b-9b10-c105347feff0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_LocalPhoneNumber_e26d07fd-693e-496b-9b10-c105347feff0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_04551e07-7f02-41dd-9b62-a5661028170e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_Security12bTitle_04551e07-7f02-41dd-9b62-a5661028170e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_c4489f63-7c06-4a4d-9d9a-8d94b9d71137" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_TradingSymbol_c4489f63-7c06-4a4d-9d9a-8d94b9d71137" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_35ef4ac9-354f-476b-a0e4-43562b527933" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_SecurityExchangeName_35ef4ac9-354f-476b-a0e4-43562b527933" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_cc7dd939-6361-49c5-b23f-849a36f65542" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityCurrentReportingStatus_cc7dd939-6361-49c5-b23f-849a36f65542" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_710ac1d0-5afa-4086-93c4-4e0c11f1180c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityInteractiveDataCurrent_710ac1d0-5afa-4086-93c4-4e0c11f1180c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_93e84d31-797e-49cd-9bc3-38041320921d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityFilerCategory_93e84d31-797e-49cd-9bc3-38041320921d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_2e93cc82-9003-4fc0-91c0-56bd2913a3f8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntitySmallBusiness_2e93cc82-9003-4fc0-91c0-56bd2913a3f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_ba0337c3-fc74-40ca-89c6-bc5482880801" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityEmergingGrowthCompany_ba0337c3-fc74-40ca-89c6-bc5482880801" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_5f2f0a6a-5dfc-4b8a-8e41-866869199cba" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityShellCompany_5f2f0a6a-5dfc-4b8a-8e41-866869199cba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_920a32b4-501c-4fb9-a0d4-627d0cc400e5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_920a32b4-501c-4fb9-a0d4-627d0cc400e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_50a5b3bb-55c2-4acf-adb7-5d7a6f36d1ab" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_EntityCentralIndexKey_50a5b3bb-55c2-4acf-adb7-5d7a6f36d1ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_5c052076-3f12-4110-8756-3a3755f6383a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_CurrentFiscalYearEndDate_5c052076-3f12-4110-8756-3a3755f6383a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_58e5b4b8-8594-47a2-95bb-300826a9deab" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_DocumentFiscalYearFocus_58e5b4b8-8594-47a2-95bb-300826a9deab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_4319327a-f78e-4f86-9d92-7b5665498685" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_DocumentFiscalPeriodFocus_4319327a-f78e-4f86-9d92-7b5665498685" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_0388d383-44d3-4475-8ebd-320479274c96" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_a6ae9b7a-b073-48b1-90ec-c67a9f82fba3" xlink:to="loc_dei_AmendmentFlag_0388d383-44d3-4475-8ebd-320479274c96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="bcrx-20220930.xsd#ConsolidatedBalanceSheets"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_e3f09b24-b30a-4fd5-9e13-6a01a5f40b12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_e3f09b24-b30a-4fd5-9e13-6a01a5f40b12" xlink:to="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_052b294a-ead7-40e7-9933-5a322a220b6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_052b294a-ead7-40e7-9933-5a322a220b6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_3093d479-01e8-4123-8201-8e048b102730" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_3093d479-01e8-4123-8201-8e048b102730" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_d2dd2a74-fbb0-4cc3-b96c-aa79b3d06afd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_d2dd2a74-fbb0-4cc3-b96c-aa79b3d06afd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_05e2b9a0-791b-4aeb-bd23-db92f9fb4da9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_05e2b9a0-791b-4aeb-bd23-db92f9fb4da9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_ab49ae65-714c-4a8f-accf-2866933e2da4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_InventoryNet_ab49ae65-714c-4a8f-accf-2866933e2da4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_f8313659-e3d6-4ced-a17a-f14b70c53519" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_f8313659-e3d6-4ced-a17a-f14b70c53519" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_094d5497-652c-4425-8e8f-571245b6bb2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_AssetsCurrent_094d5497-652c-4425-8e8f-571245b6bb2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_aa3aedb1-d2fd-4fd9-9695-fc630966c656" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_aa3aedb1-d2fd-4fd9-9695-fc630966c656" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermInvestments_6dfdcea4-e376-482b-b2ef-df30393ee646" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermInvestments"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_LongTermInvestments_6dfdcea4-e376-482b-b2ef-df30393ee646" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_922010ec-a2cc-47c5-be65-1c5d5188f9c9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_922010ec-a2cc-47c5-be65-1c5d5188f9c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_b3f1b07c-3c6f-4eee-a72e-a23a847c8520" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_cbbeac1d-7e1d-4f06-b409-c0b0913aaa41" xlink:to="loc_us-gaap_Assets_b3f1b07c-3c6f-4eee-a72e-a23a847c8520" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_e3f09b24-b30a-4fd5-9e13-6a01a5f40b12" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_b06bc1e6-55be-4fdf-83d7-b7f2124e1932" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:to="loc_us-gaap_AccountsPayableCurrent_b06bc1e6-55be-4fdf-83d7-b7f2124e1932" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_916a553f-7cc0-477c-9371-b7b5da9cb885" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_916a553f-7cc0-477c-9371-b7b5da9cb885" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredRevenueCurrent_b5d18dcb-7d75-4e98-b600-3242d2f8929f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredRevenueCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:to="loc_us-gaap_DeferredRevenueCurrent_b5d18dcb-7d75-4e98-b600-3242d2f8929f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_7e3210eb-2de0-456f-bffb-bc5983bae6e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_7e3210eb-2de0-456f-bffb-bc5983bae6e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_08bd845f-a07b-4623-bf4d-6a16805fec4b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:to="loc_us-gaap_LiabilitiesCurrent_08bd845f-a07b-4623-bf4d-6a16805fec4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_a9fee7e2-33cf-403c-b53e-165e57e0f7ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_a9fee7e2-33cf-403c-b53e-165e57e0f7ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_FutureRoyaltiesPayable_26989210-12aa-403f-8604-77f9c32ee9db" xlink:href="bcrx-20220930.xsd#bcrx_FutureRoyaltiesPayable"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:to="loc_bcrx_FutureRoyaltiesPayable_26989210-12aa-403f-8604-77f9c32ee9db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_9b0e3e2c-a7e4-41fd-a8ae-40d56d40585c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_9b0e3e2c-a7e4-41fd-a8ae-40d56d40585c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_afc217b4-2da8-43b6-aac9-05a3a40214a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:to="loc_us-gaap_StockholdersEquityAbstract_afc217b4-2da8-43b6-aac9-05a3a40214a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_602d92fb-4119-496a-acd6-dd1f081e3c40" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_afc217b4-2da8-43b6-aac9-05a3a40214a3" xlink:to="loc_us-gaap_PreferredStockValue_602d92fb-4119-496a-acd6-dd1f081e3c40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_8e1086b9-8ca7-40fd-8993-bf54ed39cae2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_afc217b4-2da8-43b6-aac9-05a3a40214a3" xlink:to="loc_us-gaap_CommonStockValue_8e1086b9-8ca7-40fd-8993-bf54ed39cae2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_10a9522b-5897-4b1c-89b3-8f4e788b72fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_afc217b4-2da8-43b6-aac9-05a3a40214a3" xlink:to="loc_us-gaap_AdditionalPaidInCapital_10a9522b-5897-4b1c-89b3-8f4e788b72fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_eabc4fc4-92ba-4159-b58a-8d2bbb04febc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_afc217b4-2da8-43b6-aac9-05a3a40214a3" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_eabc4fc4-92ba-4159-b58a-8d2bbb04febc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_a721a576-594d-4b78-a0f1-d8325436249c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_afc217b4-2da8-43b6-aac9-05a3a40214a3" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_a721a576-594d-4b78-a0f1-d8325436249c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9e4ac1ea-3f1d-44af-9baf-babec49a7c05" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_afc217b4-2da8-43b6-aac9-05a3a40214a3" xlink:to="loc_us-gaap_StockholdersEquity_9e4ac1ea-3f1d-44af-9baf-babec49a7c05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_de778293-a5d2-4006-82c7-cfbd8b227be0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_bda0dabb-f0e3-437b-acb3-a41f89cb7b21" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_de778293-a5d2-4006-82c7-cfbd8b227be0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="bcrx-20220930.xsd#ConsolidatedBalanceSheetsParenthetical"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_413f9bf2-ce2f-4331-8b2e-4e51798c2b87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_917aaf1a-a7fd-43b6-9d72-cce7f7061bb0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_413f9bf2-ce2f-4331-8b2e-4e51798c2b87" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_917aaf1a-a7fd-43b6-9d72-cce7f7061bb0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_0f3cf530-42c9-4395-b616-ec44a7bc2901" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_413f9bf2-ce2f-4331-8b2e-4e51798c2b87" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_0f3cf530-42c9-4395-b616-ec44a7bc2901" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_1c0d0753-f77e-442f-9ee5-bdef271915fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_413f9bf2-ce2f-4331-8b2e-4e51798c2b87" xlink:to="loc_us-gaap_PreferredStockSharesIssued_1c0d0753-f77e-442f-9ee5-bdef271915fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_d3666728-80b4-4f02-bf39-2f2a1c07edd9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_413f9bf2-ce2f-4331-8b2e-4e51798c2b87" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_d3666728-80b4-4f02-bf39-2f2a1c07edd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_e08e743c-2364-496b-9641-673d12321b9c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_413f9bf2-ce2f-4331-8b2e-4e51798c2b87" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_e08e743c-2364-496b-9641-673d12321b9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_7aa2196c-6d62-4230-8407-a9cda5078cb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_413f9bf2-ce2f-4331-8b2e-4e51798c2b87" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_7aa2196c-6d62-4230-8407-a9cda5078cb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_be75f86e-ad04-40b1-ace0-577ddf4c8f57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_413f9bf2-ce2f-4331-8b2e-4e51798c2b87" xlink:to="loc_us-gaap_CommonStockSharesIssued_be75f86e-ad04-40b1-ace0-577ddf4c8f57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_aac08b8c-00b9-45aa-8733-2f22d2c1d8ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_413f9bf2-ce2f-4331-8b2e-4e51798c2b87" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_aac08b8c-00b9-45aa-8733-2f22d2c1d8ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/ConsolidatedStatementsofComprehensiveLoss" xlink:type="simple" xlink:href="bcrx-20220930.xsd#ConsolidatedStatementsofComprehensiveLoss"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/ConsolidatedStatementsofComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_fe1b2496-ceef-43d9-98bb-7f1460165a1d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_0ec6abfb-ecdd-44e9-addc-796d0315a1ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_fe1b2496-ceef-43d9-98bb-7f1460165a1d" xlink:to="loc_us-gaap_StatementTable_0ec6abfb-ecdd-44e9-addc-796d0315a1ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_65201625-992c-4b7a-b8eb-147a669c5bab" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_0ec6abfb-ecdd-44e9-addc-796d0315a1ea" xlink:to="loc_srt_ProductOrServiceAxis_65201625-992c-4b7a-b8eb-147a669c5bab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_c572ede4-68e0-4233-a81a-3adf5f6c9dbb" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_65201625-992c-4b7a-b8eb-147a669c5bab" xlink:to="loc_srt_ProductsAndServicesDomain_c572ede4-68e0-4233-a81a-3adf5f6c9dbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_06a1f7d7-f93c-4db8-9106-e3447d6aa3a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProductMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_c572ede4-68e0-4233-a81a-3adf5f6c9dbb" xlink:to="loc_us-gaap_ProductMember_06a1f7d7-f93c-4db8-9106-e3447d6aa3a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_404885b7-b023-4972-b2eb-d2ad21596933" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RoyaltyMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_c572ede4-68e0-4233-a81a-3adf5f6c9dbb" xlink:to="loc_us-gaap_RoyaltyMember_404885b7-b023-4972-b2eb-d2ad21596933" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_MilestoneRevenueMember_ed9b4cf1-842b-423a-a1c3-b2f150cc71c2" xlink:href="bcrx-20220930.xsd#bcrx_MilestoneRevenueMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_c572ede4-68e0-4233-a81a-3adf5f6c9dbb" xlink:to="loc_bcrx_MilestoneRevenueMember_ed9b4cf1-842b-423a-a1c3-b2f150cc71c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_CollaborativeAndOtherResearchAndDevelopmentMember_ffc7af89-c73f-4595-bfad-cbd0226a16d7" xlink:href="bcrx-20220930.xsd#bcrx_CollaborativeAndOtherResearchAndDevelopmentMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_c572ede4-68e0-4233-a81a-3adf5f6c9dbb" xlink:to="loc_bcrx_CollaborativeAndOtherResearchAndDevelopmentMember_ffc7af89-c73f-4595-bfad-cbd0226a16d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_0ec6abfb-ecdd-44e9-addc-796d0315a1ea" xlink:to="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_ea666e7e-9fe7-4671-9e8e-b9b6c06ab120" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_RevenuesAbstract_ea666e7e-9fe7-4671-9e8e-b9b6c06ab120" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_5e87b493-f9bb-4e9a-8b9b-0aefa2494a2c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_ea666e7e-9fe7-4671-9e8e-b9b6c06ab120" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_5e87b493-f9bb-4e9a-8b9b-0aefa2494a2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_b4193b6c-06ac-4072-8c1a-88c23a0c98b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpensesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_b4193b6c-06ac-4072-8c1a-88c23a0c98b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_be0d1366-8de6-4c05-876c-220714f6529e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_b4193b6c-06ac-4072-8c1a-88c23a0c98b9" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_be0d1366-8de6-4c05-876c-220714f6529e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_298b5617-d137-449f-9a0d-f2eca01f7604" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_b4193b6c-06ac-4072-8c1a-88c23a0c98b9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_298b5617-d137-449f-9a0d-f2eca01f7604" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_7d641fc3-4292-42d6-97d7-eeccf522f176" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_b4193b6c-06ac-4072-8c1a-88c23a0c98b9" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_7d641fc3-4292-42d6-97d7-eeccf522f176" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyExpenseReversalOfExpense_b23fcbf8-3c72-4231-9876-d9136285ef49" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyExpenseReversalOfExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_b4193b6c-06ac-4072-8c1a-88c23a0c98b9" xlink:to="loc_bcrx_RoyaltyExpenseReversalOfExpense_b23fcbf8-3c72-4231-9876-d9136285ef49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_7d768db7-f035-48f8-8800-e857b543f238" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpenses"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_b4193b6c-06ac-4072-8c1a-88c23a0c98b9" xlink:to="loc_us-gaap_CostsAndExpenses_7d768db7-f035-48f8-8800-e857b543f238" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_0e518bf1-2a42-4f97-9718-dccafdfd19e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_OperatingIncomeLoss_0e518bf1-2a42-4f97-9718-dccafdfd19e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_InterestAndOtherIncomeLoss_d299d8ff-d16a-403b-a1c0-2d7e66772d2b" xlink:href="bcrx-20220930.xsd#bcrx_InterestAndOtherIncomeLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_bcrx_InterestAndOtherIncomeLoss_d299d8ff-d16a-403b-a1c0-2d7e66772d2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_947a7e62-cd50-47fd-af3e-dfb2794b776c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_InterestExpense_947a7e62-cd50-47fd-af3e-dfb2794b776c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_fe3480ec-dafe-45c9-95f0-ad4126ee059c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments_fe3480ec-dafe-45c9-95f0-ad4126ee059c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_5be28deb-ee69-43f3-b746-e4b2c932e27e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_5be28deb-ee69-43f3-b746-e4b2c932e27e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_e3eb901c-db15-4815-a6c5-643a3beb40c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_e3eb901c-db15-4815-a6c5-643a3beb40c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_bcd471af-6062-4b96-8b71-3c68af6a1e85" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_NetIncomeLoss_bcd471af-6062-4b96-8b71-3c68af6a1e85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_4a1c15e2-9d4d-47ee-be6d-8d2270d7b447" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_4a1c15e2-9d4d-47ee-be6d-8d2270d7b447" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_3965294e-ac6f-40aa-ab14-1f1d9ae0a851" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_3965294e-ac6f-40aa-ab14-1f1d9ae0a851" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_6e143a56-5ed7-4f54-9975-c2e61f71a780" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_6e143a56-5ed7-4f54-9975-c2e61f71a780" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_55657e72-8965-47a5-8904-79fcabfee3c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_EarningsPerShareBasic_55657e72-8965-47a5-8904-79fcabfee3c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_f6be2df6-65bf-4254-b91e-c861ec9b10b3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_EarningsPerShareDiluted_f6be2df6-65bf-4254-b91e-c861ec9b10b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_5eeb1d40-0ce3-42a9-974b-0305ed0a10d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_5eeb1d40-0ce3-42a9-974b-0305ed0a10d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_cbbe148b-9847-4b17-b52b-cb83cbda7010" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8f68a12c-5a7c-4f0f-8a22-5d2417f8626c" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_cbbe148b-9847-4b17-b52b-cb83cbda7010" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/ConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="bcrx-20220930.xsd#ConsolidatedStatementsofCashFlows"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/ConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_030cd9bc-8359-4de7-8c98-f1e67d480827" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_a44471b0-db83-474e-875b-9210aa9a4ba5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_030cd9bc-8359-4de7-8c98-f1e67d480827" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_a44471b0-db83-474e-875b-9210aa9a4ba5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_9c75b2ea-4026-41bd-8764-fa6e3402eb6e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_a44471b0-db83-474e-875b-9210aa9a4ba5" xlink:to="loc_us-gaap_NetIncomeLoss_9c75b2ea-4026-41bd-8764-fa6e3402eb6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c4f6216-63a9-4acf-97b0-7a922073833a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_a44471b0-db83-474e-875b-9210aa9a4ba5" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c4f6216-63a9-4acf-97b0-7a922073833a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_f6874f3d-2f1a-4db6-ae65-d038050a5f7b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c4f6216-63a9-4acf-97b0-7a922073833a" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_f6874f3d-2f1a-4db6-ae65-d038050a5f7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_d1d44661-6e9d-4d5e-9a53-426201e1261c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c4f6216-63a9-4acf-97b0-7a922073833a" xlink:to="loc_us-gaap_ShareBasedCompensation_d1d44661-6e9d-4d5e-9a53-426201e1261c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_NoncashInterestExpenseAndAmortizationOfDebtIssuanceCosts_740c102e-0b17-4dbe-b428-5cb90d3afbae" xlink:href="bcrx-20220930.xsd#bcrx_NoncashInterestExpenseAndAmortizationOfDebtIssuanceCosts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c4f6216-63a9-4acf-97b0-7a922073833a" xlink:to="loc_bcrx_NoncashInterestExpenseAndAmortizationOfDebtIssuanceCosts_740c102e-0b17-4dbe-b428-5cb90d3afbae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AmortizationOfDiscountAndPremiumOnInvestments_b9cc3ed5-8ef0-4240-966a-36f1988d4484" xlink:href="bcrx-20220930.xsd#bcrx_AmortizationOfDiscountAndPremiumOnInvestments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_2c4f6216-63a9-4acf-97b0-7a922073833a" xlink:to="loc_bcrx_AmortizationOfDiscountAndPremiumOnInvestments_b9cc3ed5-8ef0-4240-966a-36f1988d4484" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9b0a476d-36f2-49db-b7f6-ed1aa526481f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_a44471b0-db83-474e-875b-9210aa9a4ba5" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9b0a476d-36f2-49db-b7f6-ed1aa526481f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_f35abf63-8d79-40b4-9b54-f39704f40dfb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInReceivables"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9b0a476d-36f2-49db-b7f6-ed1aa526481f" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_f35abf63-8d79-40b4-9b54-f39704f40dfb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_6d31169a-0f7d-4e05-9435-90bdb70ada07" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9b0a476d-36f2-49db-b7f6-ed1aa526481f" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_6d31169a-0f7d-4e05-9435-90bdb70ada07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_b2c02e7c-6114-4d0e-b0e4-09ca09fcbbf4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9b0a476d-36f2-49db-b7f6-ed1aa526481f" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_b2c02e7c-6114-4d0e-b0e4-09ca09fcbbf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_ed98a2eb-3f51-4a18-85e4-e93770db8182" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9b0a476d-36f2-49db-b7f6-ed1aa526481f" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_ed98a2eb-3f51-4a18-85e4-e93770db8182" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInterestPayableNet_ce04b2bf-e53a-45ff-9ef4-9370cf4274b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInterestPayableNet"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9b0a476d-36f2-49db-b7f6-ed1aa526481f" xlink:to="loc_us-gaap_IncreaseDecreaseInInterestPayableNet_ce04b2bf-e53a-45ff-9ef4-9370cf4274b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_6c672063-1edd-4f45-8a9f-b6375c9b82a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9b0a476d-36f2-49db-b7f6-ed1aa526481f" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_6c672063-1edd-4f45-8a9f-b6375c9b82a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fc46df98-f5a5-4b02-9914-63b03f7f9bf4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_a44471b0-db83-474e-875b-9210aa9a4ba5" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_fc46df98-f5a5-4b02-9914-63b03f7f9bf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1a8767c8-619d-481d-b9fb-1ad792ff0617" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_030cd9bc-8359-4de7-8c98-f1e67d480827" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1a8767c8-619d-481d-b9fb-1ad792ff0617" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_432de48b-b3e2-487a-b8cb-1ee1c13d8f37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireProductiveAssets"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1a8767c8-619d-481d-b9fb-1ad792ff0617" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_432de48b-b3e2-487a-b8cb-1ee1c13d8f37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_96b279a3-1588-4615-a107-cb79fe734507" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1a8767c8-619d-481d-b9fb-1ad792ff0617" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_96b279a3-1588-4615-a107-cb79fe734507" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_7c799aa7-9502-4983-9cdb-1c9189ed41b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1a8767c8-619d-481d-b9fb-1ad792ff0617" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities_7c799aa7-9502-4983-9cdb-1c9189ed41b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_33edbce9-5614-430b-882f-ca7e08a40728" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_1a8767c8-619d-481d-b9fb-1ad792ff0617" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_33edbce9-5614-430b-882f-ca7e08a40728" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_419ad680-631f-4f5f-b38a-6b5457412d18" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_030cd9bc-8359-4de7-8c98-f1e67d480827" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_419ad680-631f-4f5f-b38a-6b5457412d18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_3adc947e-eae6-4141-a665-23ea105a4b82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_419ad680-631f-4f5f-b38a-6b5457412d18" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_3adc947e-eae6-4141-a665-23ea105a4b82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLinesOfCredit_77721099-73c8-4dfa-b533-f5d5af31bc87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromLinesOfCredit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_419ad680-631f-4f5f-b38a-6b5457412d18" xlink:to="loc_us-gaap_ProceedsFromLinesOfCredit_77721099-73c8-4dfa-b533-f5d5af31bc87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d0f3037b-99a7-429e-8871-1432a233012c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_419ad680-631f-4f5f-b38a-6b5457412d18" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d0f3037b-99a7-429e-8871-1432a233012c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_1869f7f7-df08-488a-8019-a08125b19fd9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_030cd9bc-8359-4de7-8c98-f1e67d480827" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_1869f7f7-df08-488a-8019-a08125b19fd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_7734e366-68fc-4e46-9ff9-f218dc684af1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_030cd9bc-8359-4de7-8c98-f1e67d480827" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_7734e366-68fc-4e46-9ff9-f218dc684af1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_5e57dee7-832c-49a6-9767-44bbe0b2ea48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_030cd9bc-8359-4de7-8c98-f1e67d480827" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_5e57dee7-832c-49a6-9767-44bbe0b2ea48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_1dcf53bf-a399-4a57-b032-c83448846a75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_030cd9bc-8359-4de7-8c98-f1e67d480827" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_1dcf53bf-a399-4a57-b032-c83448846a75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/ConsolidatedStatementsofStockholdersDeficit" xlink:type="simple" xlink:href="bcrx-20220930.xsd#ConsolidatedStatementsofStockholdersDeficit"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/ConsolidatedStatementsofStockholdersDeficit" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_b5b9947b-050f-427f-9e5b-da3f8d37cf84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_23b50f50-5205-46d1-aa69-e4659a64b494" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_b5b9947b-050f-427f-9e5b-da3f8d37cf84" xlink:to="loc_us-gaap_StatementTable_23b50f50-5205-46d1-aa69-e4659a64b494" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_4f641724-7964-4016-8fd2-79e896ecc011" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_23b50f50-5205-46d1-aa69-e4659a64b494" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_4f641724-7964-4016-8fd2-79e896ecc011" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_b6877c37-fc8b-48d3-8d36-283636715d90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_4f641724-7964-4016-8fd2-79e896ecc011" xlink:to="loc_us-gaap_EquityComponentDomain_b6877c37-fc8b-48d3-8d36-283636715d90" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_9bd14ef4-025e-4356-8125-32083331957c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_b6877c37-fc8b-48d3-8d36-283636715d90" xlink:to="loc_us-gaap_CommonStockMember_9bd14ef4-025e-4356-8125-32083331957c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_73fc2c1d-14a1-4b24-b494-8e605ccb011a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_b6877c37-fc8b-48d3-8d36-283636715d90" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_73fc2c1d-14a1-4b24-b494-8e605ccb011a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_b6776052-a4bb-4652-ba73-b7e8e6ae3985" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_b6877c37-fc8b-48d3-8d36-283636715d90" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_b6776052-a4bb-4652-ba73-b7e8e6ae3985" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_82369e92-cc03-480d-9754-914ec7318740" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_b6877c37-fc8b-48d3-8d36-283636715d90" xlink:to="loc_us-gaap_RetainedEarningsMember_82369e92-cc03-480d-9754-914ec7318740" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_3f363f5e-30ac-4154-9883-c7ef2eec1b72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_23b50f50-5205-46d1-aa69-e4659a64b494" xlink:to="loc_us-gaap_StatementLineItems_3f363f5e-30ac-4154-9883-c7ef2eec1b72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4de9bde5-0f2d-4aa9-a9a7-a62d806beb6d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3f363f5e-30ac-4154-9883-c7ef2eec1b72" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4de9bde5-0f2d-4aa9-a9a7-a62d806beb6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_bbcaa615-b3c1-4499-89c2-9a4c1079f12d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4de9bde5-0f2d-4aa9-a9a7-a62d806beb6d" xlink:to="loc_us-gaap_StockholdersEquity_bbcaa615-b3c1-4499-89c2-9a4c1079f12d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_5f3c0a32-6eac-4ef5-905c-240e7c7b095e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4de9bde5-0f2d-4aa9-a9a7-a62d806beb6d" xlink:to="loc_us-gaap_NetIncomeLoss_5f3c0a32-6eac-4ef5-905c-240e7c7b095e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_cea00248-9c57-49a9-8873-a1a27da93ad2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4de9bde5-0f2d-4aa9-a9a7-a62d806beb6d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_cea00248-9c57-49a9-8873-a1a27da93ad2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_StockIssuedDuringPeriodValueWarrantsExercised_9409ca27-d129-4c4a-b719-26c64cb37c41" xlink:href="bcrx-20220930.xsd#bcrx_StockIssuedDuringPeriodValueWarrantsExercised"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4de9bde5-0f2d-4aa9-a9a7-a62d806beb6d" xlink:to="loc_bcrx_StockIssuedDuringPeriodValueWarrantsExercised_9409ca27-d129-4c4a-b719-26c64cb37c41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_6afd0d75-c006-49af-a06d-06feb2f66852" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4de9bde5-0f2d-4aa9-a9a7-a62d806beb6d" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_6afd0d75-c006-49af-a06d-06feb2f66852" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_613ca156-789b-4e9a-9635-ecb03721fe76" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4de9bde5-0f2d-4aa9-a9a7-a62d806beb6d" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_613ca156-789b-4e9a-9635-ecb03721fe76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_016dded5-e573-4449-a7bd-deb19f37a2ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4de9bde5-0f2d-4aa9-a9a7-a62d806beb6d" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_016dded5-e573-4449-a7bd-deb19f37a2ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_f5c0d73f-7387-4d0d-ad65-ebcd3eff0bfb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4de9bde5-0f2d-4aa9-a9a7-a62d806beb6d" xlink:to="loc_us-gaap_StockholdersEquity_f5c0d73f-7387-4d0d-ad65-ebcd3eff0bfb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/ConsolidatedStatementsofStockholdersDeficitParenthetical" xlink:type="simple" xlink:href="bcrx-20220930.xsd#ConsolidatedStatementsofStockholdersDeficitParenthetical"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/ConsolidatedStatementsofStockholdersDeficitParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_fc06d142-04cc-407a-9cab-440a7c6d40d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_845caa09-bca0-4439-9116-b15da13a8d5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_fc06d142-04cc-407a-9cab-440a7c6d40d8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_845caa09-bca0-4439-9116-b15da13a8d5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_77642cdc-6286-42d0-a626-913313b2f4ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_fc06d142-04cc-407a-9cab-440a7c6d40d8" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_77642cdc-6286-42d0-a626-913313b2f4ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_StockIssuedDuringPeriodSharesWarrantsExercised_74a011ce-3434-4d35-a2ab-a2f93842829b" xlink:href="bcrx-20220930.xsd#bcrx_StockIssuedDuringPeriodSharesWarrantsExercised"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_fc06d142-04cc-407a-9cab-440a7c6d40d8" xlink:to="loc_bcrx_StockIssuedDuringPeriodSharesWarrantsExercised_74a011ce-3434-4d35-a2ab-a2f93842829b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRisk" xlink:type="simple" xlink:href="bcrx-20220930.xsd#SignificantAccountingPoliciesandConcentrationsofRisk"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRisk" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_039925ba-f4fd-49bb-a9b8-cf3068588b16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_c7bb9cb7-a173-4e2c-b865-5ab776eb48da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_039925ba-f4fd-49bb-a9b8-cf3068588b16" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_c7bb9cb7-a173-4e2c-b865-5ab776eb48da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/Revenue" xlink:type="simple" xlink:href="bcrx-20220930.xsd#Revenue"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/Revenue" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_441c5bfb-abea-49ce-9827-6e1737158b50" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_818531c8-ad6d-4259-87fb-e278ab3431cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_441c5bfb-abea-49ce-9827-6e1737158b50" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_818531c8-ad6d-4259-87fb-e278ab3431cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/Investments" xlink:type="simple" xlink:href="bcrx-20220930.xsd#Investments"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/Investments" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsAbstract_a4d4602f-1f95-4fb8-9db1-d8a6c616d036" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsAndOtherNoncurrentAssetsTextBlock_cbe98060-8dae-4674-a957-2ea052ee68d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsAndOtherNoncurrentAssetsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsAbstract_a4d4602f-1f95-4fb8-9db1-d8a6c616d036" xlink:to="loc_us-gaap_InvestmentsAndOtherNoncurrentAssetsTextBlock_cbe98060-8dae-4674-a957-2ea052ee68d3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/TradeReceivables" xlink:type="simple" xlink:href="bcrx-20220930.xsd#TradeReceivables"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/TradeReceivables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_6714b661-2795-4de5-bd03-6e2eb640c301" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TradeReceivablesTextBlock_dc633ef6-3042-4870-8f7c-7f3e8239e1db" xlink:href="bcrx-20220930.xsd#bcrx_TradeReceivablesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_6714b661-2795-4de5-bd03-6e2eb640c301" xlink:to="loc_bcrx_TradeReceivablesTextBlock_dc633ef6-3042-4870-8f7c-7f3e8239e1db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/Inventory" xlink:type="simple" xlink:href="bcrx-20220930.xsd#Inventory"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/Inventory" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_a28a95ff-edcf-4843-b9aa-a81875b451e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureTextBlock_6438fadd-8941-4aaf-a958-4860520ab2f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_a28a95ff-edcf-4843-b9aa-a81875b451e8" xlink:to="loc_us-gaap_InventoryDisclosureTextBlock_6438fadd-8941-4aaf-a958-4860520ab2f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/RoyaltyMonetizations" xlink:type="simple" xlink:href="bcrx-20220930.xsd#RoyaltyMonetizations"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/RoyaltyMonetizations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvanceRoyaltiesAbstract_ec84ead6-0beb-4c56-9eb3-438476b4cfcc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdvanceRoyaltiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyMonetizationTextBlock_8fcac205-316b-440b-98c5-ffc305651ca8" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyMonetizationTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdvanceRoyaltiesAbstract_ec84ead6-0beb-4c56-9eb3-438476b4cfcc" xlink:to="loc_bcrx_RoyaltyMonetizationTextBlock_8fcac205-316b-440b-98c5-ffc305651ca8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/Debt" xlink:type="simple" xlink:href="bcrx-20220930.xsd#Debt"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/Debt" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_78c0c53e-baa7-41df-9d3e-0effbd1251d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_6493eff7-82c5-4c54-a9e0-c414f9c92041" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_78c0c53e-baa7-41df-9d3e-0effbd1251d2" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_6493eff7-82c5-4c54-a9e0-c414f9c92041" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/LeaseObligations" xlink:type="simple" xlink:href="bcrx-20220930.xsd#LeaseObligations"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/LeaseObligations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_17d10c04-c963-4a55-b74f-18d20b5724a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeasesTextBlock_1ebb1d15-4dfa-4900-b32d-6f82b139bb87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeasesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_17d10c04-c963-4a55-b74f-18d20b5724a2" xlink:to="loc_us-gaap_LesseeOperatingLeasesTextBlock_1ebb1d15-4dfa-4900-b32d-6f82b139bb87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/StockholdersEquity" xlink:type="simple" xlink:href="bcrx-20220930.xsd#StockholdersEquity"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/StockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_de345beb-4636-4e70-83b5-3b95b7900acb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_de423712-77c9-436c-bbc5-25f4f06d0244" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_de345beb-4636-4e70-83b5-3b95b7900acb" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_de423712-77c9-436c-bbc5-25f4f06d0244" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/StockbasedCompensation" xlink:type="simple" xlink:href="bcrx-20220930.xsd#StockbasedCompensation"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/StockbasedCompensation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_c694318c-8edf-4073-875f-40eecae3ab7f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_4ddcebcd-5e82-4837-ae21-79d971962515" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_c694318c-8edf-4073-875f-40eecae3ab7f" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_4ddcebcd-5e82-4837-ae21-79d971962515" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/CollaborativeandOtherRelationships" xlink:type="simple" xlink:href="bcrx-20220930.xsd#CollaborativeandOtherRelationships"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/CollaborativeandOtherRelationships" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_aae6a104-d989-45a2-a88d-efc0886709c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_6e06f13b-48b8-4a72-8603-1493253d4bc9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_aae6a104-d989-45a2-a88d-efc0886709c7" xlink:to="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_6e06f13b-48b8-4a72-8603-1493253d4bc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRiskPolicies" xlink:type="simple" xlink:href="bcrx-20220930.xsd#SignificantAccountingPoliciesandConcentrationsofRiskPolicies"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRiskPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DescriptionOfCompanyPolicyTextBlock_49cc0c15-a5f8-4134-afa4-72ef413fb699" xlink:href="bcrx-20220930.xsd#bcrx_DescriptionOfCompanyPolicyTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_bcrx_DescriptionOfCompanyPolicyTextBlock_49cc0c15-a5f8-4134-afa4-72ef413fb699" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_c5d97a31-39ec-470d-affa-d4e07034499f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_c5d97a31-39ec-470d-affa-d4e07034499f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UseOfEstimates_3a785473-68cd-40f2-b13f-c52cd0ff592a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UseOfEstimates"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_UseOfEstimates_3a785473-68cd-40f2-b13f-c52cd0ff592a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRecognitionPolicyTextBlock_ecc7c1ad-a9c8-4954-a58c-47aa83fc6c78" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRecognitionPolicyTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_RevenueRecognitionPolicyTextBlock_ecc7c1ad-a9c8-4954-a58c-47aa83fc6c78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_507d1b35-3e07-4b43-910d-c7140ee9aadd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_507d1b35-3e07-4b43-910d-c7140ee9aadd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_74d53090-b473-42ce-ba90-142d495e7d5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_74d53090-b473-42ce-ba90-142d495e7d5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentPolicyTextBlock_e8741e89-289a-40e8-8173-3ba69013b7e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentPolicyTextBlock"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_InvestmentPolicyTextBlock_e8741e89-289a-40e8-8173-3ba69013b7e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesPolicyTextBlock_370e4845-7707-421a-ad98-20dba5bd4299" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReceivablesPolicyTextBlock"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_ReceivablesPolicyTextBlock_370e4845-7707-421a-ad98-20dba5bd4299" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_bdd07dab-b734-4b26-8927-f1604c099ab6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryPolicyTextBlock"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_InventoryPolicyTextBlock_bdd07dab-b734-4b26-8927-f1604c099ab6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_cb2b994c-b334-433f-af06-6cc733600a9e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_cb2b994c-b334-433f-af06-6cc733600a9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AccruedExpensesPolicyTextBlock_60430995-c2df-4f1b-8eab-7fb37e956117" xlink:href="bcrx-20220930.xsd#bcrx_AccruedExpensesPolicyTextBlock"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_bcrx_AccruedExpensesPolicyTextBlock_60430995-c2df-4f1b-8eab-7fb37e956117" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesPolicyTextBlock_c06f9832-24d3-42eb-beb9-758aec4b3087" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfSalesPolicyTextBlock"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_CostOfSalesPolicyTextBlock_c06f9832-24d3-42eb-beb9-758aec4b3087" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_1355663b-65e8-419d-8923-c8d1ecccb2d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_1355663b-65e8-419d-8923-c8d1ecccb2d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock_5e24900e-b171-48da-a946-1d6ac940f611" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpensesPolicyTextBlock_5e24900e-b171-48da-a946-1d6ac940f611" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeasesPolicyTextBlock_4ec68c81-8e95-4337-9c40-c6d1b26625f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeasesPolicyTextBlock"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_LesseeLeasesPolicyTextBlock_4ec68c81-8e95-4337-9c40-c6d1b26625f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_8ec3d4c2-5ab3-4f7f-90d6-aec1d14a099d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_8ec3d4c2-5ab3-4f7f-90d6-aec1d14a099d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_InterestExpenseAndDeferredFinancingCostsPolicyTextBlock_eb7424d2-faee-441e-8d33-7a7013d7e21d" xlink:href="bcrx-20220930.xsd#bcrx_InterestExpenseAndDeferredFinancingCostsPolicyTextBlock"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_bcrx_InterestExpenseAndDeferredFinancingCostsPolicyTextBlock_eb7424d2-faee-441e-8d33-7a7013d7e21d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_InterestExpenseAndRoyaltyFinancingObligationPolicyTextBlock_75ed048e-21cf-4cdf-9e9f-001cdbc0f7b2" xlink:href="bcrx-20220930.xsd#bcrx_InterestExpenseAndRoyaltyFinancingObligationPolicyTextBlock"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_bcrx_InterestExpenseAndRoyaltyFinancingObligationPolicyTextBlock_75ed048e-21cf-4cdf-9e9f-001cdbc0f7b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_29900895-b420-4686-9324-08decfeda51c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxPolicyTextBlock"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_IncomeTaxPolicyTextBlock_29900895-b420-4686-9324-08decfeda51c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_56cdbfb7-eb1f-4e3d-835a-262aa34e0608" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerSharePolicyTextBlock"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_56cdbfb7-eb1f-4e3d-835a-262aa34e0608" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_c871f08e-3cca-4016-bfe0-5d9624eb65a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomePolicyPolicyTextBlock"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_c871f08e-3cca-4016-bfe0-5d9624eb65a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ConcentrationOfMarketRiskPolicyTextBlock_823ef7f4-7ed9-4d03-b304-372a81ee77c4" xlink:href="bcrx-20220930.xsd#bcrx_ConcentrationOfMarketRiskPolicyTextBlock"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_bcrx_ConcentrationOfMarketRiskPolicyTextBlock_823ef7f4-7ed9-4d03-b304-372a81ee77c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_cbc3f454-52fc-4c74-ad99-bc5b1637c6d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_1482f3c9-64e3-4802-b11c-5bd59a4f28d1" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_cbc3f454-52fc-4c74-ad99-bc5b1637c6d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/RevenueTables" xlink:type="simple" xlink:href="bcrx-20220930.xsd#RevenueTables"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/RevenueTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_f8c0cb39-a55e-4e64-a2a8-36c7ec24413f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_82f95ba6-5995-4eab-81e4-0e7f946b3f7d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_f8c0cb39-a55e-4e64-a2a8-36c7ec24413f" xlink:to="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_82f95ba6-5995-4eab-81e4-0e7f946b3f7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/InvestmentsTables" xlink:type="simple" xlink:href="bcrx-20220930.xsd#InvestmentsTables"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/InvestmentsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsAbstract_78ef4f54-7d57-4a73-babf-74c9543822eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_706bfc48-c334-4b5a-97ef-923fd3a749b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsAbstract_78ef4f54-7d57-4a73-babf-74c9543822eb" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_706bfc48-c334-4b5a-97ef-923fd3a749b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_HeldToMaturitySecuritiesTextBlock_32b1867b-15f9-4eb3-8821-bef11d598225" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsAbstract_78ef4f54-7d57-4a73-babf-74c9543822eb" xlink:to="loc_us-gaap_HeldToMaturitySecuritiesTextBlock_32b1867b-15f9-4eb3-8821-bef11d598225" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/TradeReceivablesTables" xlink:type="simple" xlink:href="bcrx-20220930.xsd#TradeReceivablesTables"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/TradeReceivablesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_68f1824b-ddcd-4e37-817c-c21a192dbf5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ScheduleOfReceivablesFromCollaborationsTableTextBlock_9bb9c13c-99bf-4309-ac76-68ba3bb7d9e1" xlink:href="bcrx-20220930.xsd#bcrx_ScheduleOfReceivablesFromCollaborationsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_68f1824b-ddcd-4e37-817c-c21a192dbf5c" xlink:to="loc_bcrx_ScheduleOfReceivablesFromCollaborationsTableTextBlock_9bb9c13c-99bf-4309-ac76-68ba3bb7d9e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/InventoryTables" xlink:type="simple" xlink:href="bcrx-20220930.xsd#InventoryTables"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/InventoryTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_0882733c-ebae-4b43-a00d-a01ec15af460" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_4f78d441-7084-403a-96f0-63292ad4f833" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_0882733c-ebae-4b43-a00d-a01ec15af460" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_4f78d441-7084-403a-96f0-63292ad4f833" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/RoyaltyMonetizationsTables" xlink:type="simple" xlink:href="bcrx-20220930.xsd#RoyaltyMonetizationsTables"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/RoyaltyMonetizationsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvanceRoyaltiesAbstract_80a8693a-4625-42b8-a252-2d2071846941" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdvanceRoyaltiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyFinancingObligationsTableTextBlock_70ad01ea-768a-4f2a-9990-5ab029dee8bb" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyFinancingObligationsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdvanceRoyaltiesAbstract_80a8693a-4625-42b8-a252-2d2071846941" xlink:to="loc_bcrx_RoyaltyFinancingObligationsTableTextBlock_70ad01ea-768a-4f2a-9990-5ab029dee8bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/LeaseObligationsTables" xlink:type="simple" xlink:href="bcrx-20220930.xsd#LeaseObligationsTables"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/LeaseObligationsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_cd54aa31-fde5-4131-8b3e-9bebc9a7ae27" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCostTableTextBlock_01c6d2e2-5902-4952-ab96-8a2c175da047" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseCostTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_cd54aa31-fde5-4131-8b3e-9bebc9a7ae27" xlink:to="loc_us-gaap_LeaseCostTableTextBlock_01c6d2e2-5902-4952-ab96-8a2c175da047" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_OtherSupplementalInformationRelatedToLeasesTableTextBlock_e339e9ae-097b-431d-89ca-de8a9476215e" xlink:href="bcrx-20220930.xsd#bcrx_OtherSupplementalInformationRelatedToLeasesTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_cd54aa31-fde5-4131-8b3e-9bebc9a7ae27" xlink:to="loc_bcrx_OtherSupplementalInformationRelatedToLeasesTableTextBlock_e339e9ae-097b-431d-89ca-de8a9476215e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_LesseeOperatingLeaseAssetsAndLiabilitiesTableTextBlock_30a16aa2-1e60-4427-8ce7-ffd4cac33e67" xlink:href="bcrx-20220930.xsd#bcrx_LesseeOperatingLeaseAssetsAndLiabilitiesTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_cd54aa31-fde5-4131-8b3e-9bebc9a7ae27" xlink:to="loc_bcrx_LesseeOperatingLeaseAssetsAndLiabilitiesTableTextBlock_30a16aa2-1e60-4427-8ce7-ffd4cac33e67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock_ceb65e55-3441-480f-9e0f-b45ef379b726" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_cd54aa31-fde5-4131-8b3e-9bebc9a7ae27" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityMaturityTableTextBlock_ceb65e55-3441-480f-9e0f-b45ef379b726" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/StockbasedCompensationTables" xlink:type="simple" xlink:href="bcrx-20220930.xsd#StockbasedCompensationTables"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/StockbasedCompensationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_d7281230-d378-48d1-a6e4-f0f28cfb5067" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock_3fa48493-443a-485d-af93-aed362c7d157" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_d7281230-d378-48d1-a6e4-f0f28cfb5067" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationActivityTableTextBlock_3fa48493-443a-485d-af93-aed362c7d157" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_2c0e936f-86a8-472b-8134-191b578a4d57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_d7281230-d378-48d1-a6e4-f0f28cfb5067" xlink:to="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_2c0e936f-86a8-472b-8134-191b578a4d57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRiskDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#SignificantAccountingPoliciesandConcentrationsofRiskDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/SignificantAccountingPoliciesandConcentrationsofRiskDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_0151a7b5-eb64-4de0-8712-144c37644ad2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskTable_665df6e4-e954-4044-ab00-dfdde748a3a1" xlink:href="bcrx-20220930.xsd#bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_0151a7b5-eb64-4de0-8712-144c37644ad2" xlink:to="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskTable_665df6e4-e954-4044-ab00-dfdde748a3a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_e2e0df02-e04c-4079-9ab2-da94bf6c6c9e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskTable_665df6e4-e954-4044-ab00-dfdde748a3a1" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_e2e0df02-e04c-4079-9ab2-da94bf6c6c9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2b87d856-4643-4dda-838e-8b52cd6b63ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsAxis_e2e0df02-e04c-4079-9ab2-da94bf6c6c9e" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2b87d856-4643-4dda-838e-8b52cd6b63ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyReceivableMember_70093473-f3d0-4135-b96e-1bebc20760a7" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyReceivableMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2b87d856-4643-4dda-838e-8b52cd6b63ef" xlink:to="loc_bcrx_RoyaltyReceivableMember_70093473-f3d0-4135-b96e-1bebc20760a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_CollateralForCreditMember_66d735ff-bbc3-449f-8fac-ab21665812f7" xlink:href="bcrx-20220930.xsd#bcrx_CollateralForCreditMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_2b87d856-4643-4dda-838e-8b52cd6b63ef" xlink:to="loc_bcrx_CollateralForCreditMember_66d735ff-bbc3-449f-8fac-ab21665812f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_0f16d1a8-f9be-4123-9f88-3d5aa309caf4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskTable_665df6e4-e954-4044-ab00-dfdde748a3a1" xlink:to="loc_srt_RangeAxis_0f16d1a8-f9be-4123-9f88-3d5aa309caf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_6e52606c-8246-47e6-b421-35e8cecbb1f8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_0f16d1a8-f9be-4123-9f88-3d5aa309caf4" xlink:to="loc_srt_RangeMember_6e52606c-8246-47e6-b421-35e8cecbb1f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_03d01bde-0c16-48b6-b381-61f85077cb5a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_6e52606c-8246-47e6-b421-35e8cecbb1f8" xlink:to="loc_srt_MaximumMember_03d01bde-0c16-48b6-b381-61f85077cb5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_7484457a-3253-4397-b88b-6cc6bfe383e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskTable_665df6e4-e954-4044-ab00-dfdde748a3a1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_7484457a-3253-4397-b88b-6cc6bfe383e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_19749b37-60f7-4033-b68b-7da06e979685" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_7484457a-3253-4397-b88b-6cc6bfe383e9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_19749b37-60f7-4033-b68b-7da06e979685" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_b27beffd-c2c7-4510-bd97-5a8291f8aaf1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_19749b37-60f7-4033-b68b-7da06e979685" xlink:to="loc_us-gaap_ComputerEquipmentMember_b27beffd-c2c7-4510-bd97-5a8291f8aaf1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_LaboratoryEquipmentOfficeEquipmentAndSoftwareMember_d3857916-8a13-4d33-b00c-3699817cbee5" xlink:href="bcrx-20220930.xsd#bcrx_LaboratoryEquipmentOfficeEquipmentAndSoftwareMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_19749b37-60f7-4033-b68b-7da06e979685" xlink:to="loc_bcrx_LaboratoryEquipmentOfficeEquipmentAndSoftwareMember_d3857916-8a13-4d33-b00c-3699817cbee5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_f9ffccd6-94bb-419f-b048-b7b28070e0ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_19749b37-60f7-4033-b68b-7da06e979685" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_f9ffccd6-94bb-419f-b048-b7b28070e0ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:href="bcrx-20220930.xsd#bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskTable_665df6e4-e954-4044-ab00-dfdde748a3a1" xlink:to="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_cbf9f6e0-13df-4dc9-83b8-340a8bedbeeb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue_cbf9f6e0-13df-4dc9-83b8-340a8bedbeeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_MaturityPeriodOfHighQualityMarketableSecurities_12d94947-f131-4130-aa01-3c8e644f5aa2" xlink:href="bcrx-20220930.xsd#bcrx_MaturityPeriodOfHighQualityMarketableSecurities"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_bcrx_MaturityPeriodOfHighQualityMarketableSecurities_12d94947-f131-4130-aa01-3c8e644f5aa2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AverageMaturityPeriodOfHighQualityMarketableSecurities_efe91de0-9878-4100-9f3e-54b8cbd988f8" xlink:href="bcrx-20220930.xsd#bcrx_AverageMaturityPeriodOfHighQualityMarketableSecurities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_bcrx_AverageMaturityPeriodOfHighQualityMarketableSecurities_efe91de0-9878-4100-9f3e-54b8cbd988f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_MaturityPeriodOfShortTermInvestment_64eb2653-95b6-41f1-a894-a814375fd646" xlink:href="bcrx-20220930.xsd#bcrx_MaturityPeriodOfShortTermInvestment"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_bcrx_MaturityPeriodOfShortTermInvestment_64eb2653-95b6-41f1-a894-a814375fd646" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_LongTermInvestmentMaturityMinimum_c27da899-1721-4f74-9a25-18282b401fe5" xlink:href="bcrx-20220930.xsd#bcrx_LongTermInvestmentMaturityMinimum"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_bcrx_LongTermInvestmentMaturityMinimum_c27da899-1721-4f74-9a25-18282b401fe5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_480fef97-beeb-4bfc-9d6e-1a12d80d600e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_480fef97-beeb-4bfc-9d6e-1a12d80d600e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvertisingExpense_2456bd53-cda8-436c-a42b-1fe1780223b3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdvertisingExpense"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_us-gaap_AdvertisingExpense_2456bd53-cda8-436c-a42b-1fe1780223b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebt_9c832577-169a-4185-9203-55f3b17fd409" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseDebt"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_us-gaap_InterestExpenseDebt_9c832577-169a-4185-9203-55f3b17fd409" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AmortizationOfDebtFinancingCostsAndOriginalIssueDiscounts_a76c4832-0b72-4069-9502-9d57d1be0e46" xlink:href="bcrx-20220930.xsd#bcrx_AmortizationOfDebtFinancingCostsAndOriginalIssueDiscounts"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_bcrx_AmortizationOfDebtFinancingCostsAndOriginalIssueDiscounts_a76c4832-0b72-4069-9502-9d57d1be0e46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_ea4aeb72-0104-4bb0-adfd-8ba65587e9a4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_ea4aeb72-0104-4bb0-adfd-8ba65587e9a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_c0a4afd7-cf32-4f79-801a-9b78f23821d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_SignificantAccountingPoliciesAndConcentrationsOfRiskLineItems_8691289b-c081-4ac2-8a87-f83bc5420b5d" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_c0a4afd7-cf32-4f79-801a-9b78f23821d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/RevenueDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#RevenueDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/RevenueDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_2948b81b-7056-4077-985a-135ad5fbc826" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_482baa8e-2d80-4b1e-bb17-1ab207ce8b7f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_2948b81b-7056-4077-985a-135ad5fbc826" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_482baa8e-2d80-4b1e-bb17-1ab207ce8b7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_6c0d7c2b-f594-4bd6-9a51-df5e2b669af1" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_482baa8e-2d80-4b1e-bb17-1ab207ce8b7f" xlink:to="loc_srt_ProductOrServiceAxis_6c0d7c2b-f594-4bd6-9a51-df5e2b669af1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_74b99c51-fdc5-4b25-b5c7-d7c805354413" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_6c0d7c2b-f594-4bd6-9a51-df5e2b669af1" xlink:to="loc_srt_ProductsAndServicesDomain_74b99c51-fdc5-4b25-b5c7-d7c805354413" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProductMember_42304a45-828f-4f3a-9639-247ffd5682ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProductMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_74b99c51-fdc5-4b25-b5c7-d7c805354413" xlink:to="loc_us-gaap_ProductMember_42304a45-828f-4f3a-9639-247ffd5682ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_ef41189d-98f5-4bdd-b2ca-92a85043cfb2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RoyaltyMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_74b99c51-fdc5-4b25-b5c7-d7c805354413" xlink:to="loc_us-gaap_RoyaltyMember_ef41189d-98f5-4bdd-b2ca-92a85043cfb2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_MilestoneRevenueMember_b67962d6-ec9c-4441-8659-a0c25cc3e8ed" xlink:href="bcrx-20220930.xsd#bcrx_MilestoneRevenueMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_74b99c51-fdc5-4b25-b5c7-d7c805354413" xlink:to="loc_bcrx_MilestoneRevenueMember_b67962d6-ec9c-4441-8659-a0c25cc3e8ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_CollaborativeAndOtherResearchAndDevelopmentMember_6fffebaa-48f7-4572-8c0e-587aa0969aaf" xlink:href="bcrx-20220930.xsd#bcrx_CollaborativeAndOtherResearchAndDevelopmentMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_74b99c51-fdc5-4b25-b5c7-d7c805354413" xlink:to="loc_bcrx_CollaborativeAndOtherResearchAndDevelopmentMember_6fffebaa-48f7-4572-8c0e-587aa0969aaf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_c809c2d2-0aca-42ef-a31e-50041aa36fca" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_482baa8e-2d80-4b1e-bb17-1ab207ce8b7f" xlink:to="loc_srt_CounterpartyNameAxis_c809c2d2-0aca-42ef-a31e-50041aa36fca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_384baa86-25a0-45c0-aa67-857f6889264e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_c809c2d2-0aca-42ef-a31e-50041aa36fca" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_384baa86-25a0-45c0-aa67-857f6889264e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ORLADEYOMember_c777d878-5830-4bae-9025-313fee0b5c49" xlink:href="bcrx-20220930.xsd#bcrx_ORLADEYOMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_384baa86-25a0-45c0-aa67-857f6889264e" xlink:to="loc_bcrx_ORLADEYOMember_c777d878-5830-4bae-9025-313fee0b5c49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RAPIVABMember_0054770a-cc6a-41ef-81d8-a43ee7874819" xlink:href="bcrx-20220930.xsd#bcrx_RAPIVABMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_384baa86-25a0-45c0-aa67-857f6889264e" xlink:to="loc_bcrx_RAPIVABMember_0054770a-cc6a-41ef-81d8-a43ee7874819" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PERAMIVIRMember_cba73fef-da95-45a0-b74a-a1002d5ba008" xlink:href="bcrx-20220930.xsd#bcrx_PERAMIVIRMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_384baa86-25a0-45c0-aa67-857f6889264e" xlink:to="loc_bcrx_PERAMIVIRMember_cba73fef-da95-45a0-b74a-a1002d5ba008" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_USDepartmentOfHealthAndHumanServicesMember_dcc07179-470e-4541-92a3-ff7f5502600e" xlink:href="bcrx-20220930.xsd#bcrx_USDepartmentOfHealthAndHumanServicesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_384baa86-25a0-45c0-aa67-857f6889264e" xlink:to="loc_bcrx_USDepartmentOfHealthAndHumanServicesMember_dcc07179-470e-4541-92a3-ff7f5502600e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_61d4e62d-1ec3-42a0-9f7c-3500d71b4a0d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_482baa8e-2d80-4b1e-bb17-1ab207ce8b7f" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_61d4e62d-1ec3-42a0-9f7c-3500d71b4a0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_3caa8a4a-b510-42aa-831e-68eeeb301195" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_61d4e62d-1ec3-42a0-9f7c-3500d71b4a0d" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_3caa8a4a-b510-42aa-831e-68eeeb301195" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/InvestmentsFairValueoftheCompanysInvestmentsbyTypeDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#InvestmentsFairValueoftheCompanysInvestmentsbyTypeDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/InvestmentsFairValueoftheCompanysInvestmentsbyTypeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsAbstract_fe661a51-e3d5-446d-add0-f078860e9e9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesTable_496d250a-5c12-47ba-9fa6-e22ad6b9e226" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsAbstract_fe661a51-e3d5-446d-add0-f078860e9e9f" xlink:to="loc_us-gaap_MarketableSecuritiesTable_496d250a-5c12-47ba-9fa6-e22ad6b9e226" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_75d9e895-5f76-40b7-898b-126316426e66" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesTable_496d250a-5c12-47ba-9fa6-e22ad6b9e226" xlink:to="loc_us-gaap_FinancialInstrumentAxis_75d9e895-5f76-40b7-898b-126316426e66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d95cf0a9-1a10-45f8-90aa-36f4a5d81d73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_75d9e895-5f76-40b7-898b-126316426e66" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d95cf0a9-1a10-45f8-90aa-36f4a5d81d73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_f9aa717b-f7a6-4e4a-9382-0aae4b83f549" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d95cf0a9-1a10-45f8-90aa-36f4a5d81d73" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_f9aa717b-f7a6-4e4a-9382-0aae4b83f549" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_787f27d3-9e65-4702-a81c-15ecb22df9e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d95cf0a9-1a10-45f8-90aa-36f4a5d81d73" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_787f27d3-9e65-4702-a81c-15ecb22df9e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_3752b079-3251-4551-9814-a7c3edf2aa09" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CertificatesOfDepositMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d95cf0a9-1a10-45f8-90aa-36f4a5d81d73" xlink:to="loc_us-gaap_CertificatesOfDepositMember_3752b079-3251-4551-9814-a7c3edf2aa09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesLineItems_8a6f63c9-89e0-4144-8c4e-c580210e11e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesTable_496d250a-5c12-47ba-9fa6-e22ad6b9e226" xlink:to="loc_us-gaap_MarketableSecuritiesLineItems_8a6f63c9-89e0-4144-8c4e-c580210e11e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_02da0544-8702-4783-871f-fc634b1040be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_8a6f63c9-89e0-4144-8c4e-c580210e11e3" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_02da0544-8702-4783-871f-fc634b1040be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AvailableForSaleDebtSecuritiesAccruedInterest_3a32152e-2c3b-4586-9e40-bc8faf6b5678" xlink:href="bcrx-20220930.xsd#bcrx_AvailableForSaleDebtSecuritiesAccruedInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_8a6f63c9-89e0-4144-8c4e-c580210e11e3" xlink:to="loc_bcrx_AvailableForSaleDebtSecuritiesAccruedInterest_3a32152e-2c3b-4586-9e40-bc8faf6b5678" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_b4a9f501-fb91-49c6-afb5-14afb6ae4f9e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_8a6f63c9-89e0-4144-8c4e-c580210e11e3" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_b4a9f501-fb91-49c6-afb5-14afb6ae4f9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_725fc74d-7293-43fc-a1a8-f44bf51cbe2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_8a6f63c9-89e0-4144-8c4e-c580210e11e3" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_725fc74d-7293-43fc-a1a8-f44bf51cbe2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_0d258c41-f18d-4320-92a4-f3848b333e33" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MarketableSecuritiesLineItems_8a6f63c9-89e0-4144-8c4e-c580210e11e3" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_0d258c41-f18d-4320-92a4-f3848b333e33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/InvestmentsScheduleofMaturityofInvestmentsDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#InvestmentsScheduleofMaturityofInvestmentsDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/InvestmentsScheduleofMaturityofInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsAbstract_9afbc7ff-f17b-49f8-915c-68c6d1661854" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_7c5d1851-e34c-4122-b87f-5bac724bd80d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsAbstract_9afbc7ff-f17b-49f8-915c-68c6d1661854" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_7c5d1851-e34c-4122-b87f-5bac724bd80d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DebtSecuritiesAvailableforsaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_23302b87-0838-4b28-ad89-eebd5a4c5bde" xlink:href="bcrx-20220930.xsd#bcrx_DebtSecuritiesAvailableforsaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsAbstract_9afbc7ff-f17b-49f8-915c-68c6d1661854" xlink:to="loc_bcrx_DebtSecuritiesAvailableforsaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYearOneThroughTwo_23302b87-0838-4b28-ad89-eebd5a4c5bde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_fb625004-a1d5-4887-95d4-8443974ce699" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsAbstract_9afbc7ff-f17b-49f8-915c-68c6d1661854" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_fb625004-a1d5-4887-95d4-8443974ce699" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/TradeReceivablesDetailsTextual" xlink:type="simple" xlink:href="bcrx-20220930.xsd#TradeReceivablesDetailsTextual"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/TradeReceivablesDetailsTextual" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_1daa9ce2-07c2-48ee-9247-3952f3e69a29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_c7624aac-cc72-478e-8629-7004dd9259a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_1daa9ce2-07c2-48ee-9247-3952f3e69a29" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_c7624aac-cc72-478e-8629-7004dd9259a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_277d02ea-003f-4002-96b6-6cb8a133c073" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_c7624aac-cc72-478e-8629-7004dd9259a0" xlink:to="loc_srt_ProductOrServiceAxis_277d02ea-003f-4002-96b6-6cb8a133c073" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_0972ccd5-be56-4aec-b75a-6bae11d6d635" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_277d02ea-003f-4002-96b6-6cb8a133c073" xlink:to="loc_srt_ProductsAndServicesDomain_0972ccd5-be56-4aec-b75a-6bae11d6d635" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ORLADEYOMember_83ce40d0-5350-4aef-8818-c092a4ad7883" xlink:href="bcrx-20220930.xsd#bcrx_ORLADEYOMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_0972ccd5-be56-4aec-b75a-6bae11d6d635" xlink:to="loc_bcrx_ORLADEYOMember_83ce40d0-5350-4aef-8818-c092a4ad7883" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RAPIVABMember_e422f823-6a80-480f-96e0-9b727343da0c" xlink:href="bcrx-20220930.xsd#bcrx_RAPIVABMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_0972ccd5-be56-4aec-b75a-6bae11d6d635" xlink:to="loc_bcrx_RAPIVABMember_e422f823-6a80-480f-96e0-9b727343da0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_GreenCrossCorporationMember_b49b00c0-91ab-40eb-ba68-c14167dacb6a" xlink:href="bcrx-20220930.xsd#bcrx_GreenCrossCorporationMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_0972ccd5-be56-4aec-b75a-6bae11d6d635" xlink:to="loc_bcrx_GreenCrossCorporationMember_b49b00c0-91ab-40eb-ba68-c14167dacb6a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_b55ef89f-f52e-4acd-a7b7-b16b1d4d98ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_c7624aac-cc72-478e-8629-7004dd9259a0" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_b55ef89f-f52e-4acd-a7b7-b16b1d4d98ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivableTypeDomain_47b909e1-4e88-4858-9e20-5b1d3b7559fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReceivableTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivableByReceivableTypeAxis_b55ef89f-f52e-4acd-a7b7-b16b1d4d98ef" xlink:to="loc_us-gaap_ReceivableTypeDomain_47b909e1-4e88-4858-9e20-5b1d3b7559fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeAccountsReceivableMember_d02ca6fe-b982-474d-aba3-2bdbcd673862" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TradeAccountsReceivableMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivableTypeDomain_47b909e1-4e88-4858-9e20-5b1d3b7559fd" xlink:to="loc_us-gaap_TradeAccountsReceivableMember_d02ca6fe-b982-474d-aba3-2bdbcd673862" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_d8bbfeea-85e9-4216-b7f3-6cfbe438cac8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_c7624aac-cc72-478e-8629-7004dd9259a0" xlink:to="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_d8bbfeea-85e9-4216-b7f3-6cfbe438cac8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNet_26498e50-09d2-4146-822f-fa2b2ee24d3b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_d8bbfeea-85e9-4216-b7f3-6cfbe438cac8" xlink:to="loc_us-gaap_AccountsReceivableNet_26498e50-09d2-4146-822f-fa2b2ee24d3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/TradeReceivablesSummaryofReceivablesDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#TradeReceivablesSummaryofReceivablesDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/TradeReceivablesSummaryofReceivablesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesAbstract_4d8dde87-798e-4b8f-b1c2-e963362c4619" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReceivablesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_043e1611-8e15-4b58-b805-ab014aea3dce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesAbstract_4d8dde87-798e-4b8f-b1c2-e963362c4619" xlink:to="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_043e1611-8e15-4b58-b805-ab014aea3dce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_feb546b8-8313-48ec-800d-0815e73101bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_043e1611-8e15-4b58-b805-ab014aea3dce" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_feb546b8-8313-48ec-800d-0815e73101bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_2df7d58a-3f88-4ede-9453-4734e59c5a17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LegalEntityTypeOfCounterpartyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByLegalEntityOfCounterpartyTypeAxis_feb546b8-8313-48ec-800d-0815e73101bf" xlink:to="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_2df7d58a-3f88-4ede-9453-4734e59c5a17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_USDepartmentOfHealthAndHumanServicesMember_63bc3269-8a55-46c4-b1ee-b8f9703c3f97" xlink:href="bcrx-20220930.xsd#bcrx_USDepartmentOfHealthAndHumanServicesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_2df7d58a-3f88-4ede-9453-4734e59c5a17" xlink:to="loc_bcrx_USDepartmentOfHealthAndHumanServicesMember_63bc3269-8a55-46c4-b1ee-b8f9703c3f97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ShionogiCoLtdMember_6c1709b9-9f32-4aaf-89a6-337f18087515" xlink:href="bcrx-20220930.xsd#bcrx_ShionogiCoLtdMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_2df7d58a-3f88-4ede-9453-4734e59c5a17" xlink:to="loc_bcrx_ShionogiCoLtdMember_6c1709b9-9f32-4aaf-89a6-337f18087515" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyReceivablesFromPartnersMember_36809b99-bf8f-4fb6-b350-31127602a185" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyReceivablesFromPartnersMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LegalEntityTypeOfCounterpartyDomain_2df7d58a-3f88-4ede-9453-4734e59c5a17" xlink:to="loc_bcrx_RoyaltyReceivablesFromPartnersMember_36809b99-bf8f-4fb6-b350-31127602a185" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByBillingStatusTypeAxis_c2ce0276-f31f-460f-ba42-4e60ee7f32ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesLoansAndFinancingReceivablesByBillingStatusTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_043e1611-8e15-4b58-b805-ab014aea3dce" xlink:to="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByBillingStatusTypeAxis_c2ce0276-f31f-460f-ba42-4e60ee7f32ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesBillingStatusDomain_6d392581-8bf1-466b-b5ec-4cd958b43ae5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReceivablesBillingStatusDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesLoansAndFinancingReceivablesByBillingStatusTypeAxis_c2ce0276-f31f-460f-ba42-4e60ee7f32ca" xlink:to="loc_us-gaap_ReceivablesBillingStatusDomain_6d392581-8bf1-466b-b5ec-4cd958b43ae5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BilledRevenuesMember_c3dda8c9-d107-4c0b-bb6f-8a89b75f2599" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BilledRevenuesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesBillingStatusDomain_6d392581-8bf1-466b-b5ec-4cd958b43ae5" xlink:to="loc_us-gaap_BilledRevenuesMember_c3dda8c9-d107-4c0b-bb6f-8a89b75f2599" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnbilledRevenuesMember_2448a0f7-420f-487a-88f5-ea9a49956cca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnbilledRevenuesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReceivablesBillingStatusDomain_6d392581-8bf1-466b-b5ec-4cd958b43ae5" xlink:to="loc_us-gaap_UnbilledRevenuesMember_2448a0f7-420f-487a-88f5-ea9a49956cca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_bed052ef-ec52-4f47-a9b1-d203d6d10f33" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_043e1611-8e15-4b58-b805-ab014aea3dce" xlink:to="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_bed052ef-ec52-4f47-a9b1-d203d6d10f33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_78d7baf0-f6bb-457f-be47-ad2cb5ea76e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsNotesAndLoansReceivableLineItems_bed052ef-ec52-4f47-a9b1-d203d6d10f33" xlink:to="loc_us-gaap_ReceivablesNetCurrent_78d7baf0-f6bb-457f-be47-ad2cb5ea76e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/InventoryDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#InventoryDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/InventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_e6fda2cc-4d1b-431c-8c68-cac3664ed9c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_026f9251-c5f0-482d-bc35-ac940dd583ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryRawMaterials"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_e6fda2cc-4d1b-431c-8c68-cac3664ed9c6" xlink:to="loc_us-gaap_InventoryRawMaterials_026f9251-c5f0-482d-bc35-ac940dd583ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_0dc92fa6-c69c-4838-b9d7-a109ceb0fad3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_e6fda2cc-4d1b-431c-8c68-cac3664ed9c6" xlink:to="loc_us-gaap_InventoryWorkInProcess_0dc92fa6-c69c-4838-b9d7-a109ceb0fad3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_af891ba3-f2db-47bd-8a80-45bdeaf395ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_e6fda2cc-4d1b-431c-8c68-cac3664ed9c6" xlink:to="loc_us-gaap_InventoryFinishedGoods_af891ba3-f2db-47bd-8a80-45bdeaf395ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryGross_5dc9ebf2-6af8-4245-bbf4-3bf31ae0c324" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryGross"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_e6fda2cc-4d1b-431c-8c68-cac3664ed9c6" xlink:to="loc_us-gaap_InventoryGross_5dc9ebf2-6af8-4245-bbf4-3bf31ae0c324" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryValuationReserves_c44d1b77-beec-4a1e-b15b-29492f45b5da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryValuationReserves"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_e6fda2cc-4d1b-431c-8c68-cac3664ed9c6" xlink:to="loc_us-gaap_InventoryValuationReserves_c44d1b77-beec-4a1e-b15b-29492f45b5da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_8fda405f-9d4f-4733-83c6-20da8b98c2d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_e6fda2cc-4d1b-431c-8c68-cac3664ed9c6" xlink:to="loc_us-gaap_InventoryNet_8fda405f-9d4f-4733-83c6-20da8b98c2d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/RoyaltyMonetizationsDetailsTextual" xlink:type="simple" xlink:href="bcrx-20220930.xsd#RoyaltyMonetizationsDetailsTextual"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/RoyaltyMonetizationsDetailsTextual" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvanceRoyaltiesAbstract_dfdefa7a-efe6-4b8e-a6f8-63864f92b9d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdvanceRoyaltiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltiesMonetizationsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdvanceRoyaltiesAbstract_dfdefa7a-efe6-4b8e-a6f8-63864f92b9d9" xlink:to="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_8e957f6d-518f-45fe-9e5f-d26e9899e4e5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:to="loc_dei_LegalEntityAxis_8e957f6d-518f-45fe-9e5f-d26e9899e4e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_e76fdf47-7399-46d4-8ae8-f532071c86d2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_8e957f6d-518f-45fe-9e5f-d26e9899e4e5" xlink:to="loc_dei_EntityDomain_e76fdf47-7399-46d4-8ae8-f532071c86d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_JPRRoyaltySubLLCMember_98607343-77ba-41e7-bfd0-2fb6eddd2088" xlink:href="bcrx-20220930.xsd#bcrx_JPRRoyaltySubLLCMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_e76fdf47-7399-46d4-8ae8-f532071c86d2" xlink:to="loc_bcrx_JPRRoyaltySubLLCMember_98607343-77ba-41e7-bfd0-2fb6eddd2088" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsAxis_3ff3d7f7-7797-414c-9f7c-19319d420c8f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCommitmentsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:to="loc_us-gaap_OtherCommitmentsAxis_3ff3d7f7-7797-414c-9f7c-19319d420c8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherCommitmentsDomain_9a87f6f1-81f5-483c-99e4-6d7112abe864" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherCommitmentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsAxis_3ff3d7f7-7797-414c-9f7c-19319d420c8f" xlink:to="loc_us-gaap_OtherCommitmentsDomain_9a87f6f1-81f5-483c-99e4-6d7112abe864" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyMonetizationMember_796b49c7-8207-4a91-b8f0-1d79663bd09d" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyMonetizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherCommitmentsDomain_9a87f6f1-81f5-483c-99e4-6d7112abe864" xlink:to="loc_bcrx_RoyaltyMonetizationMember_796b49c7-8207-4a91-b8f0-1d79663bd09d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_7dd84c6f-d419-4743-bfe7-afb10187a4a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:to="loc_us-gaap_DebtInstrumentAxis_7dd84c6f-d419-4743-bfe7-afb10187a4a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_3490f5b9-ffeb-441f-8cac-5da0be32add7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_7dd84c6f-d419-4743-bfe7-afb10187a4a2" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_3490f5b9-ffeb-441f-8cac-5da0be32add7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PhaRMANotesMember_bcc4b5b9-0cdb-4471-a398-2dc1b787e473" xlink:href="bcrx-20220930.xsd#bcrx_PhaRMANotesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_3490f5b9-ffeb-441f-8cac-5da0be32add7" xlink:to="loc_bcrx_PhaRMANotesMember_bcc4b5b9-0cdb-4471-a398-2dc1b787e473" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_d9515b0f-8913-4f80-862d-41d4999e6f06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_d9515b0f-8913-4f80-862d-41d4999e6f06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a4c84b1f-211f-43c8-b44b-017411cf1843" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_d9515b0f-8913-4f80-862d-41d4999e6f06" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a4c84b1f-211f-43c8-b44b-017411cf1843" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_bf998b68-2b6d-4f75-baa3-ab7718bacc2c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_a4c84b1f-211f-43c8-b44b-017411cf1843" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_bf998b68-2b6d-4f75-baa3-ab7718bacc2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_e7b91622-0ba7-4336-8e6b-d20677342d2c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:to="loc_srt_CounterpartyNameAxis_e7b91622-0ba7-4336-8e6b-d20677342d2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_964136bd-38b2-41af-832a-daf1781c7223" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_e7b91622-0ba7-4336-8e6b-d20677342d2c" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_964136bd-38b2-41af-832a-daf1781c7223" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RPI2019IntermediateFinanceTrustMember_d603c281-8d1a-4187-8183-03ec651d473f" xlink:href="bcrx-20220930.xsd#bcrx_RPI2019IntermediateFinanceTrustMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_964136bd-38b2-41af-832a-daf1781c7223" xlink:to="loc_bcrx_RPI2019IntermediateFinanceTrustMember_d603c281-8d1a-4187-8183-03ec651d473f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RPI2021And2020IntermediateFinanceTrustMember_b7a25855-ecfc-4b10-b5cc-a536ed73f580" xlink:href="bcrx-20220930.xsd#bcrx_RPI2021And2020IntermediateFinanceTrustMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_964136bd-38b2-41af-832a-daf1781c7223" xlink:to="loc_bcrx_RPI2021And2020IntermediateFinanceTrustMember_b7a25855-ecfc-4b10-b5cc-a536ed73f580" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_The2021RPIRoyaltyPurchaseAgreementMember_e115af11-6907-47bd-bf30-349ef9333d95" xlink:href="bcrx-20220930.xsd#bcrx_The2021RPIRoyaltyPurchaseAgreementMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_964136bd-38b2-41af-832a-daf1781c7223" xlink:to="loc_bcrx_The2021RPIRoyaltyPurchaseAgreementMember_e115af11-6907-47bd-bf30-349ef9333d95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_OMERSCapitalMarketsMember_02005dc4-54ab-42ae-af81-c1470a01ce93" xlink:href="bcrx-20220930.xsd#bcrx_OMERSCapitalMarketsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_964136bd-38b2-41af-832a-daf1781c7223" xlink:to="loc_bcrx_OMERSCapitalMarketsMember_02005dc4-54ab-42ae-af81-c1470a01ce93" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_cc5e5193-16fb-4df0-a44f-66e8fad187f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_cc5e5193-16fb-4df0-a44f-66e8fad187f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_0c47794c-0eae-43dd-b7d5-67be979c2968" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_cc5e5193-16fb-4df0-a44f-66e8fad187f0" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_0c47794c-0eae-43dd-b7d5-67be979c2968" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_FutureRoyaltiesPayableMember_841eb079-86f8-4533-ac59-935a40903967" xlink:href="bcrx-20220930.xsd#bcrx_FutureRoyaltiesPayableMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_0c47794c-0eae-43dd-b7d5-67be979c2968" xlink:to="loc_bcrx_FutureRoyaltiesPayableMember_841eb079-86f8-4533-ac59-935a40903967" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_22202dc9-fb05-49df-ab2e-a5928382424a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:to="loc_srt_ProductOrServiceAxis_22202dc9-fb05-49df-ab2e-a5928382424a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_887d148f-cf9f-4de3-a4ef-36cb9e0c2d29" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_22202dc9-fb05-49df-ab2e-a5928382424a" xlink:to="loc_srt_ProductsAndServicesDomain_887d148f-cf9f-4de3-a4ef-36cb9e0c2d29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ORLADEYOMember_49757da6-981a-4e43-bd15-028e070128fd" xlink:href="bcrx-20220930.xsd#bcrx_ORLADEYOMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_887d148f-cf9f-4de3-a4ef-36cb9e0c2d29" xlink:to="loc_bcrx_ORLADEYOMember_49757da6-981a-4e43-bd15-028e070128fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_BCX9930Member_a1c93f8e-9bce-4957-96a0-8728feb71700" xlink:href="bcrx-20220930.xsd#bcrx_BCX9930Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_887d148f-cf9f-4de3-a4ef-36cb9e0c2d29" xlink:to="loc_bcrx_BCX9930Member_a1c93f8e-9bce-4957-96a0-8728feb71700" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_BCX9930BCX10013Member_139916ba-98cf-4c32-9de1-7521f366ef7e" xlink:href="bcrx-20220930.xsd#bcrx_BCX9930BCX10013Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_887d148f-cf9f-4de3-a4ef-36cb9e0c2d29" xlink:to="loc_bcrx_BCX9930BCX10013Member_139916ba-98cf-4c32-9de1-7521f366ef7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesRangeAxis_59c8fa55-79fa-4af3-a819-80b6bbf36bfc" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesRangeAxis"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:to="loc_bcrx_AnnualNetSalesRangeAxis_59c8fa55-79fa-4af3-a819-80b6bbf36bfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesRangeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_AnnualNetSalesRangeAxis_59c8fa55-79fa-4af3-a819-80b6bbf36bfc" xlink:to="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesUnder350000Member_1c65adac-60d2-4e32-beb2-43a2ff541e4a" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesUnder350000Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:to="loc_bcrx_AnnualNetSalesUnder350000Member_1c65adac-60d2-4e32-beb2-43a2ff541e4a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesBetween350000And550000Member_decd2844-492c-498e-9b41-69305f4c69bf" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesBetween350000And550000Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:to="loc_bcrx_AnnualNetSalesBetween350000And550000Member_decd2844-492c-498e-9b41-69305f4c69bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesOver550000Member_3ffc650a-9fc1-4372-a6f5-5ab59e1a312e" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesOver550000Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:to="loc_bcrx_AnnualNetSalesOver550000Member_3ffc650a-9fc1-4372-a6f5-5ab59e1a312e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesUnder150000Member_96bacf16-c7e2-4da2-af29-f615097a9524" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesUnder150000Member"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:to="loc_bcrx_AnnualNetSalesUnder150000Member_96bacf16-c7e2-4da2-af29-f615097a9524" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesBetween150000And230000Member_7cf3fc7c-34c2-4438-b61b-699135f0f85a" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesBetween150000And230000Member"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:to="loc_bcrx_AnnualNetSalesBetween150000And230000Member_7cf3fc7c-34c2-4438-b61b-699135f0f85a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesOver230000Member_78562d70-7360-4072-8c6a-ca97f390abf6" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesOver230000Member"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:to="loc_bcrx_AnnualNetSalesOver230000Member_78562d70-7360-4072-8c6a-ca97f390abf6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesUnder15BillionMember_8d2201e3-b026-4067-af4e-0acd718830e0" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesUnder15BillionMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:to="loc_bcrx_AnnualNetSalesUnder15BillionMember_8d2201e3-b026-4067-af4e-0acd718830e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesBetween15And3BillionsMember_460e6bf6-333e-4d8d-b527-1ec5908bc167" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesBetween15And3BillionsMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:to="loc_bcrx_AnnualNetSalesBetween15And3BillionsMember_460e6bf6-333e-4d8d-b527-1ec5908bc167" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualNetSalesOver3BillionsMember_5cb6c88d-be93-4874-ba9f-e94f27ee2943" xlink:href="bcrx-20220930.xsd#bcrx_AnnualNetSalesOver3BillionsMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_AnnualNetSalesRangeDomain_e970e54d-193b-48e6-856f-5949ee5c27ce" xlink:to="loc_bcrx_AnnualNetSalesOver3BillionsMember_5cb6c88d-be93-4874-ba9f-e94f27ee2943" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_996e1b5c-f1a6-4340-b492-536bb028368e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:to="loc_srt_RangeAxis_996e1b5c-f1a6-4340-b492-536bb028368e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_a5674736-6fb8-4592-826c-3af41f31d7a5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_996e1b5c-f1a6-4340-b492-536bb028368e" xlink:to="loc_srt_RangeMember_a5674736-6fb8-4592-826c-3af41f31d7a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_88f241c6-5aa7-49f3-b320-f279501798a4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_a5674736-6fb8-4592-826c-3af41f31d7a5" xlink:to="loc_srt_MinimumMember_88f241c6-5aa7-49f3-b320-f279501798a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_feffa3ef-4abe-4f6c-a585-68fbcd4ef36d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_a5674736-6fb8-4592-826c-3af41f31d7a5" xlink:to="loc_srt_MaximumMember_feffa3ef-4abe-4f6c-a585-68fbcd4ef36d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyMonetizationsLineItems"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_b0e57339-aa8d-4701-a93c-7190b8c8c86c" xlink:to="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_8a3be7e1-aaf3-4cef-bf1a-b715146b1bcb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_8a3be7e1-aaf3-4cef-bf1a-b715146b1bcb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_7e72ef51-22d1-44f3-8673-3d17d7b3cc3a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfSecuredDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_7e72ef51-22d1-44f3-8673-3d17d7b3cc3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TransactionCosts_b4eed3c6-7cb9-4016-8994-6214ee51955b" xlink:href="bcrx-20220930.xsd#bcrx_TransactionCosts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_TransactionCosts_b4eed3c6-7cb9-4016-8994-6214ee51955b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_InterestReserve_97966c1d-df1b-4774-af1f-cdd2ea43422b" xlink:href="bcrx-20220930.xsd#bcrx_InterestReserve"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_InterestReserve_97966c1d-df1b-4774-af1f-cdd2ea43422b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PrivatePlacementOfSeniorSecuredNotes_0fa7df88-7229-4fbd-bf33-2836e5b479ec" xlink:href="bcrx-20220930.xsd#bcrx_PrivatePlacementOfSeniorSecuredNotes"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_PrivatePlacementOfSeniorSecuredNotes_0fa7df88-7229-4fbd-bf33-2836e5b479ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_95f3cf8e-5490-4d3f-97a6-90afa558c188" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_95f3cf8e-5490-4d3f-97a6-90afa558c188" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebt_524db925-2f39-4395-927e-3165abb3f082" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SecuredDebt"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_us-gaap_SecuredDebt_524db925-2f39-4395-927e-3165abb3f082" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPayableCurrentAndNoncurrent_c21394c3-2629-41f9-8adb-c340bd475153" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestPayableCurrentAndNoncurrent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_us-gaap_InterestPayableCurrentAndNoncurrent_c21394c3-2629-41f9-8adb-c340bd475153" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableFairValueDisclosure_99b0a752-603e-4f57-ba8a-3778840d621c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesPayableFairValueDisclosure"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_us-gaap_NotesPayableFairValueDisclosure_99b0a752-603e-4f57-ba8a-3778840d621c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_ceb87e60-70f8-4d50-9aa7-ceb1bdee6a3c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_ceb87e60-70f8-4d50-9aa7-ceb1bdee6a3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_f195a396-0418-4f23-872b-2f6f1097c615" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_f195a396-0418-4f23-872b-2f6f1097c615" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSalesInKeyTerritories_5898e222-e2d1-4fa2-8302-a7212786c571" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSalesInKeyTerritories"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSalesInKeyTerritories_5898e222-e2d1-4fa2-8302-a7212786c571" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfGlobalAnnualNetSales_7bf75bf1-14cc-49d1-a05b-2764e69d29cc" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfGlobalAnnualNetSales"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfGlobalAnnualNetSales_7bf75bf1-14cc-49d1-a05b-2764e69d29cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfSublicenseRevenueInOtherMarkets_5d2619aa-ebaf-4661-91e0-c7662b6ca176" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfSublicenseRevenueInOtherMarkets"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfSublicenseRevenueInOtherMarkets_5d2619aa-ebaf-4661-91e0-c7662b6ca176" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSalesInOtherMarkets_7073395c-1468-4a7d-b7ee-e2eeda62db97" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSalesInOtherMarkets"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSalesInOtherMarkets_7073395c-1468-4a7d-b7ee-e2eeda62db97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesAnnualNetSalesPaymentThreshold_c8959fdb-13d7-492c-8bf1-1204387f93ac" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPurchaseAgreementRoyaltiesAnnualNetSalesPaymentThreshold"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesAnnualNetSalesPaymentThreshold_c8959fdb-13d7-492c-8bf1-1204387f93ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesMaximumTieredProfitSharePercentageOnPermittedSalesInOtherMarkets_b1fb4ed9-58be-4056-9bf1-8d0477bd4fe7" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPurchaseAgreementRoyaltiesMaximumTieredProfitSharePercentageOnPermittedSalesInOtherMarkets"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesMaximumTieredProfitSharePercentageOnPermittedSalesInOtherMarkets_b1fb4ed9-58be-4056-9bf1-8d0477bd4fe7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSales_cfcda91a-a403-4a64-9d42-4a592d65fc24" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSales"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSales_cfcda91a-a403-4a64-9d42-4a592d65fc24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSalesBasedOnReductionInSales_20173912-a9c6-4579-901d-cbf69bc017d5" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSalesBasedOnReductionInSales"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfAnnualNetSalesBasedOnReductionInSales_20173912-a9c6-4579-901d-cbf69bc017d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfPurchasePrice_33b2a03a-5676-4af9-b2f6-e4405ff6eca7" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfPurchasePrice"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPercentageOfPurchasePrice_33b2a03a-5676-4af9-b2f6-e4405ff6eca7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPurchasePriceAmount_941d8dc0-fdbf-4b6b-b916-e708ec4d2c8e" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPurchaseAgreementRoyaltiesPurchasePriceAmount"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_RoyaltyPurchaseAgreementRoyaltiesPurchasePriceAmount_941d8dc0-fdbf-4b6b-b916-e708ec4d2c8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_71972a73-8e42-4cc0-85b7-7cacdd074964" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_71972a73-8e42-4cc0-85b7-7cacdd074964" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_SharesIssuedCommonStockPremium_26e7069d-38e8-4fc1-beed-71702ad5fd0b" xlink:href="bcrx-20220930.xsd#bcrx_SharesIssuedCommonStockPremium"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_0666817a-286f-4b1a-9db3-942a7d9793cf" xlink:to="loc_bcrx_SharesIssuedCommonStockPremium_26e7069d-38e8-4fc1-beed-71702ad5fd0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/RoyaltyMonetizationsScheduleofRoyaltyFinancingObligationsDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#RoyaltyMonetizationsScheduleofRoyaltyFinancingObligationsDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/RoyaltyMonetizationsScheduleofRoyaltyFinancingObligationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdvanceRoyaltiesAbstract_2b4544bb-0d29-47b9-8f14-119542f02393" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdvanceRoyaltiesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltiesMonetizationsTable_d0c248e3-5f90-4ecc-899e-2b6054ff9169" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltiesMonetizationsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdvanceRoyaltiesAbstract_2b4544bb-0d29-47b9-8f14-119542f02393" xlink:to="loc_bcrx_RoyaltiesMonetizationsTable_d0c248e3-5f90-4ecc-899e-2b6054ff9169" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_fbf24708-d334-49d0-84b5-ec2232b3d353" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_d0c248e3-5f90-4ecc-899e-2b6054ff9169" xlink:to="loc_srt_CounterpartyNameAxis_fbf24708-d334-49d0-84b5-ec2232b3d353" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a190c189-9ab1-469d-86e3-4ba30e8f8738" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_fbf24708-d334-49d0-84b5-ec2232b3d353" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a190c189-9ab1-469d-86e3-4ba30e8f8738" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TwentyTwentyRPIRoyaltyAgreementMember_b6be750f-6a41-44bf-a5f4-83393ed9aa17" xlink:href="bcrx-20220930.xsd#bcrx_TwentyTwentyRPIRoyaltyAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a190c189-9ab1-469d-86e3-4ba30e8f8738" xlink:to="loc_bcrx_TwentyTwentyRPIRoyaltyAgreementMember_b6be750f-6a41-44bf-a5f4-83393ed9aa17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TwentyTwentyOneRPIRoyaltyAgreementMember_3bd24ffb-8f25-47d2-a2fa-d37b489f0591" xlink:href="bcrx-20220930.xsd#bcrx_TwentyTwentyOneRPIRoyaltyAgreementMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a190c189-9ab1-469d-86e3-4ba30e8f8738" xlink:to="loc_bcrx_TwentyTwentyOneRPIRoyaltyAgreementMember_3bd24ffb-8f25-47d2-a2fa-d37b489f0591" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_OMERSRoyaltyAgreementMember_d0d826f6-5252-4f63-9bad-5850a0dc88fe" xlink:href="bcrx-20220930.xsd#bcrx_OMERSRoyaltyAgreementMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_a190c189-9ab1-469d-86e3-4ba30e8f8738" xlink:to="loc_bcrx_OMERSRoyaltyAgreementMember_d0d826f6-5252-4f63-9bad-5850a0dc88fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_ce1cf9b4-19d1-42df-945d-225294ec2c80" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_d0c248e3-5f90-4ecc-899e-2b6054ff9169" xlink:to="loc_srt_RangeAxis_ce1cf9b4-19d1-42df-945d-225294ec2c80" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_684e3195-5d9a-45a1-96f5-05f59ee74b88" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_ce1cf9b4-19d1-42df-945d-225294ec2c80" xlink:to="loc_srt_RangeMember_684e3195-5d9a-45a1-96f5-05f59ee74b88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_a01a7637-abf8-4831-90f3-46fd614657d9" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_684e3195-5d9a-45a1-96f5-05f59ee74b88" xlink:to="loc_srt_MaximumMember_a01a7637-abf8-4831-90f3-46fd614657d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_be6ea88c-0f3c-4b65-8345-e9571f34dd12" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_684e3195-5d9a-45a1-96f5-05f59ee74b88" xlink:to="loc_srt_MinimumMember_be6ea88c-0f3c-4b65-8345-e9571f34dd12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyMonetizationsLineItems_2ac737ca-c73d-4020-b41a-ab0fc997e171" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyMonetizationsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltiesMonetizationsTable_d0c248e3-5f90-4ecc-899e-2b6054ff9169" xlink:to="loc_bcrx_RoyaltyMonetizationsLineItems_2ac737ca-c73d-4020-b41a-ab0fc997e171" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyMontizationsRollForward_4b8695c3-672d-415d-956d-07a6248bd0b9" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyMontizationsRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMonetizationsLineItems_2ac737ca-c73d-4020-b41a-ab0fc997e171" xlink:to="loc_bcrx_RoyaltyMontizationsRollForward_4b8695c3-672d-415d-956d-07a6248bd0b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_FutureRoyaltiesPayable_2ed8c769-d275-4559-84e5-57e9490d0eb5" xlink:href="bcrx-20220930.xsd#bcrx_FutureRoyaltiesPayable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMontizationsRollForward_4b8695c3-672d-415d-956d-07a6248bd0b9" xlink:to="loc_bcrx_FutureRoyaltiesPayable_2ed8c769-d275-4559-84e5-57e9490d0eb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_5b730492-eba9-4988-b1d6-dfb183f6e1fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfFinancingCosts"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMontizationsRollForward_4b8695c3-672d-415d-956d-07a6248bd0b9" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_5b730492-eba9-4988-b1d6-dfb183f6e1fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_NonCashInterestExpenseOnRoyaltyFinancingObligation_c67df09e-f866-4918-8c15-2d10e0a1e58a" xlink:href="bcrx-20220930.xsd#bcrx_NonCashInterestExpenseOnRoyaltyFinancingObligation"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMontizationsRollForward_4b8695c3-672d-415d-956d-07a6248bd0b9" xlink:to="loc_bcrx_NonCashInterestExpenseOnRoyaltyFinancingObligation_c67df09e-f866-4918-8c15-2d10e0a1e58a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltiesRevenuesPaidAndPayable_32fb89f6-077d-46bc-80d2-ceda557f2ca1" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltiesRevenuesPaidAndPayable"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMontizationsRollForward_4b8695c3-672d-415d-956d-07a6248bd0b9" xlink:to="loc_bcrx_RoyaltiesRevenuesPaidAndPayable_32fb89f6-077d-46bc-80d2-ceda557f2ca1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_FutureRoyaltiesPayable_0af31dc0-bcc4-4817-8913-299ac7f6c144" xlink:href="bcrx-20220930.xsd#bcrx_FutureRoyaltiesPayable"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMontizationsRollForward_4b8695c3-672d-415d-956d-07a6248bd0b9" xlink:to="loc_bcrx_FutureRoyaltiesPayable_0af31dc0-bcc4-4817-8913-299ac7f6c144" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_ee9d31ec-7148-41fd-b335-07ab4a08fe22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_RoyaltyMontizationsRollForward_4b8695c3-672d-415d-956d-07a6248bd0b9" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_ee9d31ec-7148-41fd-b335-07ab4a08fe22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/DebtDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#DebtDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/DebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_d9d77997-4e66-4b18-8baa-6ba40359ae82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_d5d57552-37f6-4e10-b682-691975496d50" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_d9d77997-4e66-4b18-8baa-6ba40359ae82" xlink:to="loc_us-gaap_DebtInstrumentTable_d5d57552-37f6-4e10-b682-691975496d50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_4e705315-b613-45e2-9025-43e3184d6e97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d5d57552-37f6-4e10-b682-691975496d50" xlink:to="loc_us-gaap_DebtInstrumentAxis_4e705315-b613-45e2-9025-43e3184d6e97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_46363050-0f03-420c-904f-d399f3c5072d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_4e705315-b613-45e2-9025-43e3184d6e97" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_46363050-0f03-420c-904f-d399f3c5072d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_CreditAgreementMember_bc461ac7-87f5-4290-994d-9a919f47c8e0" xlink:href="bcrx-20220930.xsd#bcrx_CreditAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_46363050-0f03-420c-904f-d399f3c5072d" xlink:to="loc_bcrx_CreditAgreementMember_bc461ac7-87f5-4290-994d-9a919f47c8e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_df1eb3f4-34aa-458d-a6b8-d769822fecfb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d5d57552-37f6-4e10-b682-691975496d50" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_df1eb3f4-34aa-458d-a6b8-d769822fecfb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_67fba284-b4ca-430e-9b3f-41b2d3246c2c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityLenderDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_df1eb3f4-34aa-458d-a6b8-d769822fecfb" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_67fba284-b4ca-430e-9b3f-41b2d3246c2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AthyriumMember_6482e203-19e1-4df6-ad97-aa4f76cf6142" xlink:href="bcrx-20220930.xsd#bcrx_AthyriumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_67fba284-b4ca-430e-9b3f-41b2d3246c2c" xlink:to="loc_bcrx_AthyriumMember_6482e203-19e1-4df6-ad97-aa4f76cf6142" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_MidCapFinancialServicesLLCMember_e23103b4-8842-4805-8487-e36cca9a4ee8" xlink:href="bcrx-20220930.xsd#bcrx_MidCapFinancialServicesLLCMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_67fba284-b4ca-430e-9b3f-41b2d3246c2c" xlink:to="loc_bcrx_MidCapFinancialServicesLLCMember_e23103b4-8842-4805-8487-e36cca9a4ee8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_e7004351-28bb-4b49-b618-5397b0945755" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d5d57552-37f6-4e10-b682-691975496d50" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_e7004351-28bb-4b49-b618-5397b0945755" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_847d4500-cb34-4fa4-90cc-d7017736c063" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_e7004351-28bb-4b49-b618-5397b0945755" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_847d4500-cb34-4fa4-90cc-d7017736c063" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TermALoanMember_06e45344-3770-45da-bebc-4bcaf04993b0" xlink:href="bcrx-20220930.xsd#bcrx_TermALoanMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_847d4500-cb34-4fa4-90cc-d7017736c063" xlink:to="loc_bcrx_TermALoanMember_06e45344-3770-45da-bebc-4bcaf04993b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TermBLoanMember_48b01f01-3447-471e-8634-f523b39ef5e7" xlink:href="bcrx-20220930.xsd#bcrx_TermBLoanMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_847d4500-cb34-4fa4-90cc-d7017736c063" xlink:to="loc_bcrx_TermBLoanMember_48b01f01-3447-471e-8634-f523b39ef5e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TermCLoanMember_e7d7eccf-9253-4156-aff1-206f21947734" xlink:href="bcrx-20220930.xsd#bcrx_TermCLoanMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_847d4500-cb34-4fa4-90cc-d7017736c063" xlink:to="loc_bcrx_TermCLoanMember_e7d7eccf-9253-4156-aff1-206f21947734" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TermBAndCLoanMember_54cb1968-e703-4197-9eca-248baf7bb4c9" xlink:href="bcrx-20220930.xsd#bcrx_TermBAndCLoanMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_847d4500-cb34-4fa4-90cc-d7017736c063" xlink:to="loc_bcrx_TermBAndCLoanMember_54cb1968-e703-4197-9eca-248baf7bb4c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_0e1af7fd-ea8e-4e29-9973-cd720267d273" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d5d57552-37f6-4e10-b682-691975496d50" xlink:to="loc_us-gaap_CreditFacilityAxis_0e1af7fd-ea8e-4e29-9973-cd720267d273" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_5fb83774-18f3-4384-9801-e90f9159c398" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityAxis_0e1af7fd-ea8e-4e29-9973-cd720267d273" xlink:to="loc_us-gaap_CreditFacilityDomain_5fb83774-18f3-4384-9801-e90f9159c398" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_SeniorCreditFacilityMember_b565b3dc-f9ae-4ddf-8cfc-abc74ed42978" xlink:href="bcrx-20220930.xsd#bcrx_SeniorCreditFacilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_5fb83774-18f3-4384-9801-e90f9159c398" xlink:to="loc_bcrx_SeniorCreditFacilityMember_b565b3dc-f9ae-4ddf-8cfc-abc74ed42978" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_4d4dbf39-2195-42fc-bef1-01f6bdb000b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d5d57552-37f6-4e10-b682-691975496d50" xlink:to="loc_us-gaap_VariableRateAxis_4d4dbf39-2195-42fc-bef1-01f6bdb000b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_f6637017-08c0-4e9e-9cf3-8d45aee72835" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_4d4dbf39-2195-42fc-bef1-01f6bdb000b2" xlink:to="loc_us-gaap_VariableRateDomain_f6637017-08c0-4e9e-9cf3-8d45aee72835" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_a5f9ab42-7e06-4057-ac61-9a75f5043dec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_f6637017-08c0-4e9e-9cf3-8d45aee72835" xlink:to="loc_us-gaap_LondonInterbankOfferedRateLIBORMember_a5f9ab42-7e06-4057-ac61-9a75f5043dec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DebtCovenantTermsAxis_d74781aa-ef69-4dd8-ae49-a3a2366dfbde" xlink:href="bcrx-20220930.xsd#bcrx_DebtCovenantTermsAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d5d57552-37f6-4e10-b682-691975496d50" xlink:to="loc_bcrx_DebtCovenantTermsAxis_d74781aa-ef69-4dd8-ae49-a3a2366dfbde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:href="bcrx-20220930.xsd#bcrx_DebtCovenantTermsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_DebtCovenantTermsAxis_d74781aa-ef69-4dd8-ae49-a3a2366dfbde" xlink:to="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PikInterestPaymentIsMadeMember_538cd664-f750-4256-a692-73a27caff5f6" xlink:href="bcrx-20220930.xsd#bcrx_PikInterestPaymentIsMadeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:to="loc_bcrx_PikInterestPaymentIsMadeMember_538cd664-f750-4256-a692-73a27caff5f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PriorToTheSecondAnniversaryMember_4142efaa-ea0d-4f01-8dfe-4acf3baeb27a" xlink:href="bcrx-20220930.xsd#bcrx_PriorToTheSecondAnniversaryMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:to="loc_bcrx_PriorToTheSecondAnniversaryMember_4142efaa-ea0d-4f01-8dfe-4acf3baeb27a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_BetweenTheSecondAndThirdAnniversariesMember_89f1b34a-2490-412e-8fba-470dedae9668" xlink:href="bcrx-20220930.xsd#bcrx_BetweenTheSecondAndThirdAnniversariesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:to="loc_bcrx_BetweenTheSecondAndThirdAnniversariesMember_89f1b34a-2490-412e-8fba-470dedae9668" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_BetweenTheThirdAndFourthAnniversariesMember_68fb44c3-62d9-4f98-bb7d-ecd6fa9fe25e" xlink:href="bcrx-20220930.xsd#bcrx_BetweenTheThirdAndFourthAnniversariesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:to="loc_bcrx_BetweenTheThirdAndFourthAnniversariesMember_68fb44c3-62d9-4f98-bb7d-ecd6fa9fe25e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AfterFourthAnniversaryMember_65a52114-2fea-4375-b3d7-1c3c9c4781cf" xlink:href="bcrx-20220930.xsd#bcrx_AfterFourthAnniversaryMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:to="loc_bcrx_AfterFourthAnniversaryMember_65a52114-2fea-4375-b3d7-1c3c9c4781cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TermLoanADrawnMember_45ec2c08-8fa6-4b48-990e-b8968c70dd9c" xlink:href="bcrx-20220930.xsd#bcrx_TermLoanADrawnMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:to="loc_bcrx_TermLoanADrawnMember_45ec2c08-8fa6-4b48-990e-b8968c70dd9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TermLoanAAndBDrawnMember_871f869a-aac3-48d9-a80d-fc5cbaeead54" xlink:href="bcrx-20220930.xsd#bcrx_TermLoanAAndBDrawnMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:to="loc_bcrx_TermLoanAAndBDrawnMember_871f869a-aac3-48d9-a80d-fc5cbaeead54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TermLoansABAndCDrawnMember_18179d1a-81fa-4bac-9715-8566092cc32a" xlink:href="bcrx-20220930.xsd#bcrx_TermLoansABAndCDrawnMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:to="loc_bcrx_TermLoansABAndCDrawnMember_18179d1a-81fa-4bac-9715-8566092cc32a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_TermLoansABAndCDrawnAndCureRightExercisedMember_c59e9ccc-46de-48f3-aa7f-d0fa1a3e751a" xlink:href="bcrx-20220930.xsd#bcrx_TermLoansABAndCDrawnAndCureRightExercisedMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_DebtCovenantTermsDomain_4972c3a4-e9ff-4f06-8a7f-2ee82cf39594" xlink:to="loc_bcrx_TermLoansABAndCDrawnAndCureRightExercisedMember_c59e9ccc-46de-48f3-aa7f-d0fa1a3e751a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d5d57552-37f6-4e10-b682-691975496d50" xlink:to="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_c96a1193-fbd3-44ab-a352-2cf1cbc11c8c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_c96a1193-fbd3-44ab-a352-2cf1cbc11c8c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_7a335bca-020e-4009-8c0c-bdc82ab2d814" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_7a335bca-020e-4009-8c0c-bdc82ab2d814" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLinesOfCredit_d76a0c30-721b-4dc4-aa7f-deae36bb2242" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfLinesOfCredit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_us-gaap_RepaymentsOfLinesOfCredit_d76a0c30-721b-4dc4-aa7f-deae36bb2242" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DebtInstrumentLiborFloor_6d637861-1999-45be-9cdb-8ab4f346a6d2" xlink:href="bcrx-20220930.xsd#bcrx_DebtInstrumentLiborFloor"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_bcrx_DebtInstrumentLiborFloor_6d637861-1999-45be-9cdb-8ab4f346a6d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DebtInstrumentLiborCap_bfda690d-fdf6-465b-a737-a1cad3d0ecd1" xlink:href="bcrx-20220930.xsd#bcrx_DebtInstrumentLiborCap"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_bcrx_DebtInstrumentLiborCap_bfda690d-fdf6-465b-a737-a1cad3d0ecd1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_ea2cb046-ed69-48b8-8796-3f38a0da504f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_ea2cb046-ed69-48b8-8796-3f38a0da504f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DebtInstrumentPrepaymentFeePercentageOfPrincipalVoluntaryPayments_20727c30-460c-44c0-afe5-e57672815696" xlink:href="bcrx-20220930.xsd#bcrx_DebtInstrumentPrepaymentFeePercentageOfPrincipalVoluntaryPayments"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_bcrx_DebtInstrumentPrepaymentFeePercentageOfPrincipalVoluntaryPayments_20727c30-460c-44c0-afe5-e57672815696" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DebtInstrumentPrepaymentFeePercentageOfAccruedInterest_67eecbbc-bc10-482f-8123-a9c3048ffc59" xlink:href="bcrx-20220930.xsd#bcrx_DebtInstrumentPrepaymentFeePercentageOfAccruedInterest"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_bcrx_DebtInstrumentPrepaymentFeePercentageOfAccruedInterest_67eecbbc-bc10-482f-8123-a9c3048ffc59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DebtInstrumentExitFeePercentageOfPrincipal_4b3dabfd-1b63-44e0-b80e-2b0d66c33fff" xlink:href="bcrx-20220930.xsd#bcrx_DebtInstrumentExitFeePercentageOfPrincipal"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_bcrx_DebtInstrumentExitFeePercentageOfPrincipal_4b3dabfd-1b63-44e0-b80e-2b0d66c33fff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DebtInstrumentCommitmentFeePercentage_448addac-79d2-421d-98cb-018f421cd2d6" xlink:href="bcrx-20220930.xsd#bcrx_DebtInstrumentCommitmentFeePercentage"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_bcrx_DebtInstrumentCommitmentFeePercentage_448addac-79d2-421d-98cb-018f421cd2d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_DebtInstrumentCovenantMinimumUnrestrictedCashAndCashEquivalents_1664d2e9-e18a-4aa2-8cfb-33f1fef2dc85" xlink:href="bcrx-20220930.xsd#bcrx_DebtInstrumentCovenantMinimumUnrestrictedCashAndCashEquivalents"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_bcrx_DebtInstrumentCovenantMinimumUnrestrictedCashAndCashEquivalents_1664d2e9-e18a-4aa2-8cfb-33f1fef2dc85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_26ecc9c2-c59e-4515-b754-25a5bb39e383" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_26ecc9c2-c59e-4515-b754-25a5bb39e383" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaidInKindInterest_46717632-fe3b-4fb6-ac59-66b7ff270be0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaidInKindInterest"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_us-gaap_PaidInKindInterest_46717632-fe3b-4fb6-ac59-66b7ff270be0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_726e56b1-2c46-407e-adf9-66e20c7bf055" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_us-gaap_LongTermDebt_726e56b1-2c46-407e-adf9-66e20c7bf055" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_a2a871e7-5814-4160-b01b-82c15b86e39c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_a2a871e7-5814-4160-b01b-82c15b86e39c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_25db6288-5f55-44a4-9d0e-7686b0f3939c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_25db6288-5f55-44a4-9d0e-7686b0f3939c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_b0a7e513-1b2a-4c57-ab91-400f84f9a836" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0b3b6aa8-107f-440a-8def-b64139375454" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_b0a7e513-1b2a-4c57-ab91-400f84f9a836" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/LeaseObligationsDetailsTextual" xlink:type="simple" xlink:href="bcrx-20220930.xsd#LeaseObligationsDetailsTextual"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/LeaseObligationsDetailsTextual" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_c4290e24-9e4b-4d24-b162-ea12bf3a5439" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_aff042da-7a1c-430c-887a-38ea4ebc275f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_c4290e24-9e4b-4d24-b162-ea12bf3a5439" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_aff042da-7a1c-430c-887a-38ea4ebc275f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_b61498ef-4514-4c71-8234-2466391b9635" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_aff042da-7a1c-430c-887a-38ea4ebc275f" xlink:to="loc_srt_RangeAxis_b61498ef-4514-4c71-8234-2466391b9635" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_b1d910d6-2c56-4022-86d2-d0e62a1aac86" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_b61498ef-4514-4c71-8234-2466391b9635" xlink:to="loc_srt_RangeMember_b1d910d6-2c56-4022-86d2-d0e62a1aac86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_6a2fd9f2-f051-4deb-8f42-9478d4591883" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_b1d910d6-2c56-4022-86d2-d0e62a1aac86" xlink:to="loc_srt_MinimumMember_6a2fd9f2-f051-4deb-8f42-9478d4591883" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_15fe61a9-f1c2-4f6b-b20a-880db3b2c7a4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_b1d910d6-2c56-4022-86d2-d0e62a1aac86" xlink:to="loc_srt_MaximumMember_15fe61a9-f1c2-4f6b-b20a-880db3b2c7a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_4763c864-71d1-4883-b05b-ce5ce7a108e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_aff042da-7a1c-430c-887a-38ea4ebc275f" xlink:to="loc_us-gaap_LesseeLeaseDescriptionLineItems_4763c864-71d1-4883-b05b-ce5ce7a108e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseTermOfContract_58138ea6-5957-4a2c-a354-f9d4147337ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseTermOfContract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_4763c864-71d1-4883-b05b-ce5ce7a108e9" xlink:to="loc_us-gaap_LesseeOperatingLeaseTermOfContract_58138ea6-5957-4a2c-a354-f9d4147337ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_311b3d99-c405-4da4-bef2-090067a78ce8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_4763c864-71d1-4883-b05b-ce5ce7a108e9" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_311b3d99-c405-4da4-bef2-090067a78ce8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_571bee16-0e9b-4b1a-acdf-ddd7cabadeb5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_4763c864-71d1-4883-b05b-ce5ce7a108e9" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_571bee16-0e9b-4b1a-acdf-ddd7cabadeb5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_OperatingLeaseRightOfUseAssetAccumulatedAmortization_7b081cc2-323c-4201-a1d7-6812b9ef8b9f" xlink:href="bcrx-20220930.xsd#bcrx_OperatingLeaseRightOfUseAssetAccumulatedAmortization"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_4763c864-71d1-4883-b05b-ce5ce7a108e9" xlink:to="loc_bcrx_OperatingLeaseRightOfUseAssetAccumulatedAmortization_7b081cc2-323c-4201-a1d7-6812b9ef8b9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasePayments_f765658b-a2bc-4ecf-bbb3-ba6d0fa9fa65" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasePayments"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_4763c864-71d1-4883-b05b-ce5ce7a108e9" xlink:to="loc_us-gaap_OperatingLeasePayments_f765658b-a2bc-4ecf-bbb3-ba6d0fa9fa65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/LeaseObligationsAggregateLeaseExpenseUnderOperatingLeasesDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#LeaseObligationsAggregateLeaseExpenseUnderOperatingLeasesDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/LeaseObligationsAggregateLeaseExpenseUnderOperatingLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_81098b49-4b83-4ade-94d4-d9f037aba0c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AggregateLeaseExpense_92c6ba75-7cf1-4e92-a9c8-2ae68c752b2e" xlink:href="bcrx-20220930.xsd#bcrx_AggregateLeaseExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_81098b49-4b83-4ade-94d4-d9f037aba0c4" xlink:to="loc_bcrx_AggregateLeaseExpense_92c6ba75-7cf1-4e92-a9c8-2ae68c752b2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/LeaseObligationsOtherSupplementalInformationRelatedtoLeasesDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#LeaseObligationsOtherSupplementalInformationRelatedtoLeasesDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/LeaseObligationsOtherSupplementalInformationRelatedtoLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_9c4375f2-108b-44da-ba32-b10fcbdecb19" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_483cc6cd-e3cf-402d-8504-d84c0e00d3b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_9c4375f2-108b-44da-ba32-b10fcbdecb19" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_483cc6cd-e3cf-402d-8504-d84c0e00d3b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_adf2eee1-af8d-41e2-ae8f-461570f95b11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_9c4375f2-108b-44da-ba32-b10fcbdecb19" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_adf2eee1-af8d-41e2-ae8f-461570f95b11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/LeaseObligationsBalanceSheetsoftheCompanysOperatingLeasesDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#LeaseObligationsBalanceSheetsoftheCompanysOperatingLeasesDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/LeaseObligationsBalanceSheetsoftheCompanysOperatingLeasesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_46ab9748-1245-4f1c-80e2-a339c0f707af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_OperatingLeaseAssets_60f000f0-8a64-4979-ab1e-a5ab0d55af0e" xlink:href="bcrx-20220930.xsd#bcrx_OperatingLeaseAssets"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_46ab9748-1245-4f1c-80e2-a339c0f707af" xlink:to="loc_bcrx_OperatingLeaseAssets_60f000f0-8a64-4979-ab1e-a5ab0d55af0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_8b8f5e68-17d8-4130-a905-b36360569ee9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_OperatingLeaseAssets_60f000f0-8a64-4979-ab1e-a5ab0d55af0e" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_8b8f5e68-17d8-4130-a905-b36360569ee9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList_6b1fcc64-4744-4ec8-9918-abad879aa870" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_bcrx_OperatingLeaseAssets_60f000f0-8a64-4979-ab1e-a5ab0d55af0e" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetStatementOfFinancialPositionExtensibleList_6b1fcc64-4744-4ec8-9918-abad879aa870" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityAbstract_85c57bc2-f4f3-4ccb-9145-942360993d9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_46ab9748-1245-4f1c-80e2-a339c0f707af" xlink:to="loc_us-gaap_OperatingLeaseLiabilityAbstract_85c57bc2-f4f3-4ccb-9145-942360993d9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_bc76ed09-5890-4da7-b5d9-f4c13349f309" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilityAbstract_85c57bc2-f4f3-4ccb-9145-942360993d9f" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_bc76ed09-5890-4da7-b5d9-f4c13349f309" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_be7e2d14-04b1-4bee-8bb0-bfffece62a4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilityAbstract_85c57bc2-f4f3-4ccb-9145-942360993d9f" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_be7e2d14-04b1-4bee-8bb0-bfffece62a4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_479ea482-4f6f-4852-92e2-3fcb51a7f1dd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeaseLiabilityAbstract_85c57bc2-f4f3-4ccb-9145-942360993d9f" xlink:to="loc_us-gaap_OperatingLeaseLiability_479ea482-4f6f-4852-92e2-3fcb51a7f1dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/LeaseObligationsMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#LeaseObligationsMaturitiesofOperatingLeaseLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/LeaseObligationsMaturitiesofOperatingLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_f4bbecc4-38c9-4156-b0a5-eba67a3396ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_f4bbecc4-38c9-4156-b0a5-eba67a3396ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_9406e913-e6f3-4ae3-a530-afee996521e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_9406e913-e6f3-4ae3-a530-afee996521e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_40cb4d92-922a-45d3-b158-1886124af4eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_40cb4d92-922a-45d3-b158-1886124af4eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_d19a200b-e688-4a2d-ad48-58c872fb6f6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_d19a200b-e688-4a2d-ad48-58c872fb6f6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_ff7306c1-899a-4f00-bb0f-cfb0c3cc98a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_ff7306c1-899a-4f00-bb0f-cfb0c3cc98a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_d692b6f1-3564-45fa-b512-6022d2f011df" xlink:href="bcrx-20220930.xsd#bcrx_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:to="loc_bcrx_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_d692b6f1-3564-45fa-b512-6022d2f011df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_26502302-d30a-4328-8b55-5b8c48d848c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_26502302-d30a-4328-8b55-5b8c48d848c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_ec397de7-6659-4c21-bfe5-710b4d07ff96" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_ec397de7-6659-4c21-bfe5-710b4d07ff96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_17531a11-de3b-4fca-a732-befd7c6739f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:to="loc_us-gaap_OperatingLeaseLiability_17531a11-de3b-4fca-a732-befd7c6739f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityStatementOfFinancialPositionExtensibleList_85225dc3-1998-4a37-8aee-657598fa94a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityStatementOfFinancialPositionExtensibleList"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_1ac05a16-8423-429d-a76c-376cf84e190a" xlink:to="loc_us-gaap_OperatingLeaseLiabilityStatementOfFinancialPositionExtensibleList_85225dc3-1998-4a37-8aee-657598fa94a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/StockholdersEquityDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#StockholdersEquityDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/StockholdersEquityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_bef4cc26-c4ab-497f-8c55-34312bc47a06" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_befb9441-f43c-4fc1-8671-b60f2d3c4f69" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_bef4cc26-c4ab-497f-8c55-34312bc47a06" xlink:to="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_befb9441-f43c-4fc1-8671-b60f2d3c4f69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_7701357a-ebe1-41f5-a69c-45a9b491ec13" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_befb9441-f43c-4fc1-8671-b60f2d3c4f69" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_7701357a-ebe1-41f5-a69c-45a9b491ec13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_3adfeff0-47c7-4cb2-804d-366ba3b56d67" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_7701357a-ebe1-41f5-a69c-45a9b491ec13" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_3adfeff0-47c7-4cb2-804d-366ba3b56d67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_CommonStockPurchaseAgreementWithRPIMember_11d8b12f-f8d7-4f64-a80b-c85f9a8cecfd" xlink:href="bcrx-20220930.xsd#bcrx_CommonStockPurchaseAgreementWithRPIMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_3adfeff0-47c7-4cb2-804d-366ba3b56d67" xlink:to="loc_bcrx_CommonStockPurchaseAgreementWithRPIMember_11d8b12f-f8d7-4f64-a80b-c85f9a8cecfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockLineItems_6db4ba28-457c-4f65-87ec-e5e234abc9ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiaryOrEquityMethodInvesteeSaleOfStockBySubsidiaryOrEquityInvesteeTable_befb9441-f43c-4fc1-8671-b60f2d3c4f69" xlink:to="loc_us-gaap_SubsidiarySaleOfStockLineItems_6db4ba28-457c-4f65-87ec-e5e234abc9ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_MaximumAggregateOfferingPrice_9cda05fd-336a-4b75-8607-504e2c28df22" xlink:href="bcrx-20220930.xsd#bcrx_MaximumAggregateOfferingPrice"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_6db4ba28-457c-4f65-87ec-e5e234abc9ec" xlink:to="loc_bcrx_MaximumAggregateOfferingPrice_9cda05fd-336a-4b75-8607-504e2c28df22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_8bbb3704-b0a5-457c-be61-c510be195e03" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_6db4ba28-457c-4f65-87ec-e5e234abc9ec" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_8bbb3704-b0a5-457c-be61-c510be195e03" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_daad3fef-1353-48e2-a270-060655c18cbd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_6db4ba28-457c-4f65-87ec-e5e234abc9ec" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_daad3fef-1353-48e2-a270-060655c18cbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesIssuedPricePerShare_2b567e0f-b57f-442c-8ff3-4341ee67218e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesIssuedPricePerShare"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_6db4ba28-457c-4f65-87ec-e5e234abc9ec" xlink:to="loc_us-gaap_SharesIssuedPricePerShare_2b567e0f-b57f-442c-8ff3-4341ee67218e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_SharesIssuedPricePerSharePremium_6ab26e24-3399-4468-8c01-5c1e78b86cf5" xlink:href="bcrx-20220930.xsd#bcrx_SharesIssuedPricePerSharePremium"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_6db4ba28-457c-4f65-87ec-e5e234abc9ec" xlink:to="loc_bcrx_SharesIssuedPricePerSharePremium_6ab26e24-3399-4468-8c01-5c1e78b86cf5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_SharesIssuedPricePerShareClosingPrice_2225a961-ce03-41fb-89e7-318d19716f18" xlink:href="bcrx-20220930.xsd#bcrx_SharesIssuedPricePerShareClosingPrice"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_6db4ba28-457c-4f65-87ec-e5e234abc9ec" xlink:to="loc_bcrx_SharesIssuedPricePerShareClosingPrice_2225a961-ce03-41fb-89e7-318d19716f18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_SharesIssuedCommonStockPremium_716e6a60-187a-4a40-89cb-b2bc2d75e004" xlink:href="bcrx-20220930.xsd#bcrx_SharesIssuedCommonStockPremium"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockLineItems_6db4ba28-457c-4f65-87ec-e5e234abc9ec" xlink:to="loc_bcrx_SharesIssuedCommonStockPremium_716e6a60-187a-4a40-89cb-b2bc2d75e004" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/StockbasedCompensationDetailsTextual" xlink:type="simple" xlink:href="bcrx-20220930.xsd#StockbasedCompensationDetailsTextual"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/StockbasedCompensationDetailsTextual" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_417c2cb7-e505-4835-9631-ee06f2d3fa1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a75eda43-0da2-4e24-aaaa-3cdc703c1de1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_417c2cb7-e505-4835-9631-ee06f2d3fa1b" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a75eda43-0da2-4e24-aaaa-3cdc703c1de1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_47d43e4f-6233-4e7d-919d-f2612a9f4d8b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a75eda43-0da2-4e24-aaaa-3cdc703c1de1" xlink:to="loc_us-gaap_PlanNameAxis_47d43e4f-6233-4e7d-919d-f2612a9f4d8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_c4b376dd-a021-4e5b-a05e-0efbfc136311" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_47d43e4f-6233-4e7d-919d-f2612a9f4d8b" xlink:to="loc_us-gaap_PlanNameDomain_c4b376dd-a021-4e5b-a05e-0efbfc136311" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_IncentivePlanMember_5f1697b7-7b9f-474a-ae7a-edaa6b0a0be8" xlink:href="bcrx-20220930.xsd#bcrx_IncentivePlanMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_c4b376dd-a021-4e5b-a05e-0efbfc136311" xlink:to="loc_bcrx_IncentivePlanMember_5f1697b7-7b9f-474a-ae7a-edaa6b0a0be8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_InducementPlanMember_fd04debd-6fad-49c5-9131-542b1f682699" xlink:href="bcrx-20220930.xsd#bcrx_InducementPlanMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_c4b376dd-a021-4e5b-a05e-0efbfc136311" xlink:to="loc_bcrx_InducementPlanMember_fd04debd-6fad-49c5-9131-542b1f682699" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_EmployeeStockPurchasePlanMember_657e96a0-7dce-4cc4-8c86-ba8aa990f5a2" xlink:href="bcrx-20220930.xsd#bcrx_EmployeeStockPurchasePlanMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_c4b376dd-a021-4e5b-a05e-0efbfc136311" xlink:to="loc_bcrx_EmployeeStockPurchasePlanMember_657e96a0-7dce-4cc4-8c86-ba8aa990f5a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_2620a9b0-f555-40d7-8950-a9841be42188" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a75eda43-0da2-4e24-aaaa-3cdc703c1de1" xlink:to="loc_us-gaap_AwardTypeAxis_2620a9b0-f555-40d7-8950-a9841be42188" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3a18b372-2036-4150-97b1-93c6143f96a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_2620a9b0-f555-40d7-8950-a9841be42188" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3a18b372-2036-4150-97b1-93c6143f96a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_812eb369-2912-4e68-821b-64f7a109fc45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3a18b372-2036-4150-97b1-93c6143f96a3" xlink:to="loc_us-gaap_EmployeeStockOptionMember_812eb369-2912-4e68-821b-64f7a109fc45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_7e3d8ebb-6590-4d12-a0b9-5d16774bcc2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PerformanceSharesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3a18b372-2036-4150-97b1-93c6143f96a3" xlink:to="loc_us-gaap_PerformanceSharesMember_7e3d8ebb-6590-4d12-a0b9-5d16774bcc2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PerformancebasedRestrictedStockUnitsMember_9e21da00-02f6-4430-94a3-6af372ba3786" xlink:href="bcrx-20220930.xsd#bcrx_PerformancebasedRestrictedStockUnitsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3a18b372-2036-4150-97b1-93c6143f96a3" xlink:to="loc_bcrx_PerformancebasedRestrictedStockUnitsMember_9e21da00-02f6-4430-94a3-6af372ba3786" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_33564f6e-d0e1-4de8-97a4-875ccf0feb10" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3a18b372-2036-4150-97b1-93c6143f96a3" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_33564f6e-d0e1-4de8-97a4-875ccf0feb10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingAxis_b1fb761d-8fb4-4d49-83b4-425724c3e0e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VestingAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a75eda43-0da2-4e24-aaaa-3cdc703c1de1" xlink:to="loc_us-gaap_VestingAxis_b1fb761d-8fb4-4d49-83b4-425724c3e0e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingDomain_20031e8d-320c-4db4-8469-6da8135ad82b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VestingDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingAxis_b1fb761d-8fb4-4d49-83b4-425724c3e0e0" xlink:to="loc_us-gaap_VestingDomain_20031e8d-320c-4db4-8469-6da8135ad82b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_Vest25PercentEachYearUntilFullyVestedMember_5cf5eda2-998d-49f8-a5a7-d3364120ff84" xlink:href="bcrx-20220930.xsd#bcrx_Vest25PercentEachYearUntilFullyVestedMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingDomain_20031e8d-320c-4db4-8469-6da8135ad82b" xlink:to="loc_bcrx_Vest25PercentEachYearUntilFullyVestedMember_5cf5eda2-998d-49f8-a5a7-d3364120ff84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_VestUponSuccessfulCompletionOfSpecificDevelopmentMilestonesMember_e7368a84-b9f1-4161-96ca-9d8b6dc38e50" xlink:href="bcrx-20220930.xsd#bcrx_VestUponSuccessfulCompletionOfSpecificDevelopmentMilestonesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingDomain_20031e8d-320c-4db4-8469-6da8135ad82b" xlink:to="loc_bcrx_VestUponSuccessfulCompletionOfSpecificDevelopmentMilestonesMember_e7368a84-b9f1-4161-96ca-9d8b6dc38e50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_2566e4cc-4272-4902-b929-ef6fc9b00f70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationAwardTrancheOneMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingDomain_20031e8d-320c-4db4-8469-6da8135ad82b" xlink:to="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_2566e4cc-4272-4902-b929-ef6fc9b00f70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ThirtysixEqualMonthlyInstallmentsMember_a877d96e-742d-45a7-8aec-e3161b9f158b" xlink:href="bcrx-20220930.xsd#bcrx_ThirtysixEqualMonthlyInstallmentsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingDomain_20031e8d-320c-4db4-8469-6da8135ad82b" xlink:to="loc_bcrx_ThirtysixEqualMonthlyInstallmentsMember_a877d96e-742d-45a7-8aec-e3161b9f158b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_378319b4-f972-44a4-a58c-ac79ef4f9267" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a75eda43-0da2-4e24-aaaa-3cdc703c1de1" xlink:to="loc_srt_TitleOfIndividualAxis_378319b4-f972-44a4-a58c-ac79ef4f9267" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_e4535ff3-a098-48cb-a6ec-400c3a4c89e5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_TitleOfIndividualAxis_378319b4-f972-44a4-a58c-ac79ef4f9267" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_e4535ff3-a098-48cb-a6ec-400c3a4c89e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_NonEmployeeDirectorsMember_f7d895fd-3a6b-4da4-b5d5-f0635b74c4f7" xlink:href="bcrx-20220930.xsd#bcrx_NonEmployeeDirectorsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_e4535ff3-a098-48cb-a6ec-400c3a4c89e5" xlink:to="loc_bcrx_NonEmployeeDirectorsMember_f7d895fd-3a6b-4da4-b5d5-f0635b74c4f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_3a015522-b493-4bc2-b68e-aa7d7b7bdded" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a75eda43-0da2-4e24-aaaa-3cdc703c1de1" xlink:to="loc_srt_RangeAxis_3a015522-b493-4bc2-b68e-aa7d7b7bdded" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_1f70dc3b-d3ee-4814-9215-1a2ca6375437" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_3a015522-b493-4bc2-b68e-aa7d7b7bdded" xlink:to="loc_srt_RangeMember_1f70dc3b-d3ee-4814-9215-1a2ca6375437" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_3506b42c-2bb4-4129-aacc-454c121027ae" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_1f70dc3b-d3ee-4814-9215-1a2ca6375437" xlink:to="loc_srt_MaximumMember_3506b42c-2bb4-4129-aacc-454c121027ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_a75eda43-0da2-4e24-aaaa-3cdc703c1de1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ShareBasedPaymentArrangementNumberOfPlans_575f9c95-9fea-443c-97f5-85bb28ea8bd0" xlink:href="bcrx-20220930.xsd#bcrx_ShareBasedPaymentArrangementNumberOfPlans"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_bcrx_ShareBasedPaymentArrangementNumberOfPlans_575f9c95-9fea-443c-97f5-85bb28ea8bd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_9fe29d73-59f4-4718-947c-1bba7eeeb7b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_9fe29d73-59f4-4718-947c-1bba7eeeb7b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_d62ca596-988f-42ee-a757-32e579809e6e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_d62ca596-988f-42ee-a757-32e579809e6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedForRemainderOfFiscalYear_214a7816-1532-4e75-80da-ba55981b6fc2" xlink:href="bcrx-20220930.xsd#bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedForRemainderOfFiscalYear"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedForRemainderOfFiscalYear_214a7816-1532-4e75-80da-ba55981b6fc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedNextYear_8a84914b-6682-4d06-a967-7e92ff8a4c91" xlink:href="bcrx-20220930.xsd#bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedNextYear"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedNextYear_8a84914b-6682-4d06-a967-7e92ff8a4c91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedYearTwo_e6010a48-94a5-4c75-af59-bd22fe79370a" xlink:href="bcrx-20220930.xsd#bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedYearTwo"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedYearTwo_e6010a48-94a5-4c75-af59-bd22fe79370a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedYearThree_677a7ddd-c858-4485-a58d-4ed8cdde63ce" xlink:href="bcrx-20220930.xsd#bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedYearThree"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedYearThree_677a7ddd-c858-4485-a58d-4ed8cdde63ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedYearFour_728c45e3-0fd9-4dca-9a5f-b89608f30e47" xlink:href="bcrx-20220930.xsd#bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedYearFour"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_bcrx_EmployeeServiceShareBasedCompensationNonvestedAwardsCompensationCostExpectedToBeRecognizedYearFour_728c45e3-0fd9-4dca-9a5f-b89608f30e47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_dc8b56b8-3dc2-4246-9675-77a3515f9947" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_dc8b56b8-3dc2-4246-9675-77a3515f9947" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_d75a92ca-7f5c-49bc-b4f7-f104fe10b41d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_d75a92ca-7f5c-49bc-b4f7-f104fe10b41d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_608b5df2-4e09-4265-b3d6-2fe4c82242c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_608b5df2-4e09-4265-b3d6-2fe4c82242c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_306e45b7-0b39-4fa9-91f5-871d3029d18b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGranted_306e45b7-0b39-4fa9-91f5-871d3029d18b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_aeb6e5b0-ca9c-40d0-a5d4-a998b1372b01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_aeb6e5b0-ca9c-40d0-a5d4-a998b1372b01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_a49de71e-e562-43c8-a567-8d9a0731f6a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_a49de71e-e562-43c8-a567-8d9a0731f6a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7fff0da9-1078-48d8-b973-b00d5b74407f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7fff0da9-1078-48d8-b973-b00d5b74407f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_c3f445b9-3a44-43bc-9898-ea9b3fabedba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_c3f445b9-3a44-43bc-9898-ea9b3fabedba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_3741c865-0d51-41a3-9b22-c7549fea621f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_3741c865-0d51-41a3-9b22-c7549fea621f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_9e87b737-9396-4b6c-af9e-1c79adc432ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_9e87b737-9396-4b6c-af9e-1c79adc432ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_16a220ae-667a-43ab-a810-642d4b0e5af3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_16a220ae-667a-43ab-a810-642d4b0e5af3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PercentageOfSalaryToPurchaseCommonStockMaximum_6303dea1-7b84-4fdf-af89-b7e01721ce24" xlink:href="bcrx-20220930.xsd#bcrx_PercentageOfSalaryToPurchaseCommonStockMaximum"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_bcrx_PercentageOfSalaryToPurchaseCommonStockMaximum_6303dea1-7b84-4fdf-af89-b7e01721ce24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PercentageOfCommonStockSharesBeginning_f0e35059-329f-4c01-b304-44929665b3c7" xlink:href="bcrx-20220930.xsd#bcrx_PercentageOfCommonStockSharesBeginning"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_bcrx_PercentageOfCommonStockSharesBeginning_f0e35059-329f-4c01-b304-44929665b3c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PercentageOfCommonStockSharesEnding_a25138ad-4385-45c2-a878-c1d56bbcfbdc" xlink:href="bcrx-20220930.xsd#bcrx_PercentageOfCommonStockSharesEnding"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_bcrx_PercentageOfCommonStockSharesEnding_a25138ad-4385-45c2-a878-c1d56bbcfbdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee_83c7437e-c045-440b-8540-69a1547b28b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee_83c7437e-c045-440b-8540-69a1547b28b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployeeAmount_081fe1dc-5f5b-49c9-9d07-3eb612d69bfc" xlink:href="bcrx-20220930.xsd#bcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployeeAmount"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_bcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployeeAmount_081fe1dc-5f5b-49c9-9d07-3eb612d69bfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_0c6a264b-1b15-4f8e-9071-d53c0d0b574d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3b3246cd-ae0c-409b-9da1-2f437ea0f264" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_0c6a264b-1b15-4f8e-9071-d53c0d0b574d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/StockbasedCompensationStockPlanActivitiesDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#StockbasedCompensationStockPlanActivitiesDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/StockbasedCompensationStockPlanActivitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_de02b347-1c77-4c8b-bf07-ac1e178eb7ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e438690a-8dd2-42fa-a37a-b53c7ccba293" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_de02b347-1c77-4c8b-bf07-ac1e178eb7ec" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e438690a-8dd2-42fa-a37a-b53c7ccba293" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_91b3ab2a-9323-4d03-9427-d794805b6751" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e438690a-8dd2-42fa-a37a-b53c7ccba293" xlink:to="loc_us-gaap_PlanNameAxis_91b3ab2a-9323-4d03-9427-d794805b6751" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_f98f3b8e-6e96-4109-a071-b84e3ef3cf7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_91b3ab2a-9323-4d03-9427-d794805b6751" xlink:to="loc_us-gaap_PlanNameDomain_f98f3b8e-6e96-4109-a071-b84e3ef3cf7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_IncentivePlanMember_0ea2e824-801d-4ac1-98f0-f2b04cc3bfc2" xlink:href="bcrx-20220930.xsd#bcrx_IncentivePlanMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_f98f3b8e-6e96-4109-a071-b84e3ef3cf7e" xlink:to="loc_bcrx_IncentivePlanMember_0ea2e824-801d-4ac1-98f0-f2b04cc3bfc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_InducementPlanMember_4191e4a1-b755-4e36-8aca-11eb61c22a87" xlink:href="bcrx-20220930.xsd#bcrx_InducementPlanMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_f98f3b8e-6e96-4109-a071-b84e3ef3cf7e" xlink:to="loc_bcrx_InducementPlanMember_4191e4a1-b755-4e36-8aca-11eb61c22a87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0df26004-1b91-4235-88f9-0b12fc9ce4f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e438690a-8dd2-42fa-a37a-b53c7ccba293" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0df26004-1b91-4235-88f9-0b12fc9ce4f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalGeneralDisclosuresAbstract_b191ae88-10f1-4095-bd01-1200d87bcf2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalGeneralDisclosuresAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0df26004-1b91-4235-88f9-0b12fc9ce4f1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalGeneralDisclosuresAbstract_b191ae88-10f1-4095-bd01-1200d87bcf2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_e14fb474-321b-4e05-8719-00d7cbd24c41" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalGeneralDisclosuresAbstract_b191ae88-10f1-4095-bd01-1200d87bcf2b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_e14fb474-321b-4e05-8719-00d7cbd24c41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPlanAmendmentAwardsInShares_60efb7a9-2f1f-40b6-bf78-6af2061b9c3b" xlink:href="bcrx-20220930.xsd#bcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPlanAmendmentAwardsInShares"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalGeneralDisclosuresAbstract_b191ae88-10f1-4095-bd01-1200d87bcf2b" xlink:to="loc_bcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPlanAmendmentAwardsInShares_60efb7a9-2f1f-40b6-bf78-6af2061b9c3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_4008510a-c4f9-4909-8bb5-f0d4ff348f1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalGeneralDisclosuresAbstract_b191ae88-10f1-4095-bd01-1200d87bcf2b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_4008510a-c4f9-4909-8bb5-f0d4ff348f1a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_e667a5e3-f69b-4e78-b01e-cd5f256f0850" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalGeneralDisclosuresAbstract_b191ae88-10f1-4095-bd01-1200d87bcf2b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_e667a5e3-f69b-4e78-b01e-cd5f256f0850" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodAwardsAvailable_35d69600-eb63-4910-a599-c3731df4d051" xlink:href="bcrx-20220930.xsd#bcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodAwardsAvailable"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalGeneralDisclosuresAbstract_b191ae88-10f1-4095-bd01-1200d87bcf2b" xlink:to="loc_bcrx_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodAwardsAvailable_35d69600-eb63-4910-a599-c3731df4d051" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsForfeituresInPeriodAwardsAvailable_d03fdf2b-93ab-46ea-a115-435102abada3" xlink:href="bcrx-20220930.xsd#bcrx_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsForfeituresInPeriodAwardsAvailable"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalGeneralDisclosuresAbstract_b191ae88-10f1-4095-bd01-1200d87bcf2b" xlink:to="loc_bcrx_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsForfeituresInPeriodAwardsAvailable_d03fdf2b-93ab-46ea-a115-435102abada3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_644bf056-3a7e-4989-98a1-571dbe98d597" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAdditionalGeneralDisclosuresAbstract_b191ae88-10f1-4095-bd01-1200d87bcf2b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_644bf056-3a7e-4989-98a1-571dbe98d597" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_aa94229d-b470-4a00-a1c6-a615f2f04d2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0df26004-1b91-4235-88f9-0b12fc9ce4f1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_aa94229d-b470-4a00-a1c6-a615f2f04d2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_32b147f7-5542-4cab-88e2-80d8d8c9a33e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_aa94229d-b470-4a00-a1c6-a615f2f04d2e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_32b147f7-5542-4cab-88e2-80d8d8c9a33e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_f9c0dc63-f99d-4a8d-9c7a-748bab9889e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_aa94229d-b470-4a00-a1c6-a615f2f04d2e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_f9c0dc63-f99d-4a8d-9c7a-748bab9889e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_7bd3a1d5-9773-4897-b612-bf7e4e0cf7fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_aa94229d-b470-4a00-a1c6-a615f2f04d2e" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_7bd3a1d5-9773-4897-b612-bf7e4e0cf7fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriod_fd063132-b802-40cb-80b5-19ab5c75cf3a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_aa94229d-b470-4a00-a1c6-a615f2f04d2e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriod_fd063132-b802-40cb-80b5-19ab5c75cf3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_bc24b592-85d1-44de-9ecb-6289dcd1b482" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_aa94229d-b470-4a00-a1c6-a615f2f04d2e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_bc24b592-85d1-44de-9ecb-6289dcd1b482" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePriceAbstract_2f12f093-b614-4493-984a-7bbffe8fc1de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePriceAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0df26004-1b91-4235-88f9-0b12fc9ce4f1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePriceAbstract_2f12f093-b614-4493-984a-7bbffe8fc1de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_7e044850-9710-4510-a25d-22c0546a1657" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePriceAbstract_2f12f093-b614-4493-984a-7bbffe8fc1de" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_7e044850-9710-4510-a25d-22c0546a1657" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_0c3efd8e-f4dd-4338-9821-ca3ca5339adb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePriceAbstract_2f12f093-b614-4493-984a-7bbffe8fc1de" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_0c3efd8e-f4dd-4338-9821-ca3ca5339adb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_66d7d6ef-7f1e-49d0-8578-b5ac58b99163" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePriceAbstract_2f12f093-b614-4493-984a-7bbffe8fc1de" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_66d7d6ef-7f1e-49d0-8578-b5ac58b99163" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice_c29e05b8-05af-4cd1-8b42-afa4572d6a78" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePriceAbstract_2f12f093-b614-4493-984a-7bbffe8fc1de" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePrice_c29e05b8-05af-4cd1-8b42-afa4572d6a78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_8dfa78d0-40f7-4262-8992-136d509c832d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodWeightedAverageExercisePriceAbstract_2f12f093-b614-4493-984a-7bbffe8fc1de" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_8dfa78d0-40f7-4262-8992-136d509c832d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/StockbasedCompensationWeightedAverageAssumptionsforStockOptionAwardsGrantedtoEmployeesandDirectorsUnderthePlansDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#StockbasedCompensationWeightedAverageAssumptionsforStockOptionAwardsGrantedtoEmployeesandDirectorsUnderthePlansDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/StockbasedCompensationWeightedAverageAssumptionsforStockOptionAwardsGrantedtoEmployeesandDirectorsUnderthePlansDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_e5746737-8b9d-44a2-bcae-d3394d967687" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6bb816be-f74c-494b-9952-8a8e0d041ec1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_e5746737-8b9d-44a2-bcae-d3394d967687" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6bb816be-f74c-494b-9952-8a8e0d041ec1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_e55f85a0-100f-4c25-b315-5530af544a43" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6bb816be-f74c-494b-9952-8a8e0d041ec1" xlink:to="loc_us-gaap_PlanNameAxis_e55f85a0-100f-4c25-b315-5530af544a43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_fce7d0f5-3674-4004-8263-3103437a734d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_e55f85a0-100f-4c25-b315-5530af544a43" xlink:to="loc_us-gaap_PlanNameDomain_fce7d0f5-3674-4004-8263-3103437a734d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_IncentivePlanAndInducementPlanMember_6f372b95-f1f1-4608-8cbf-f04685728bb9" xlink:href="bcrx-20220930.xsd#bcrx_IncentivePlanAndInducementPlanMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_fce7d0f5-3674-4004-8263-3103437a734d" xlink:to="loc_bcrx_IncentivePlanAndInducementPlanMember_6f372b95-f1f1-4608-8cbf-f04685728bb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_91f904da-abb2-4be1-a703-1c5fa064f76a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_6bb816be-f74c-494b-9952-8a8e0d041ec1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_91f904da-abb2-4be1-a703-1c5fa064f76a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_37f026c5-3d67-409c-ab7c-303eeae90f46" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_91f904da-abb2-4be1-a703-1c5fa064f76a" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_37f026c5-3d67-409c-ab7c-303eeae90f46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_7648d052-9426-4fe5-a07c-7de81a8960c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_91f904da-abb2-4be1-a703-1c5fa064f76a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_7648d052-9426-4fe5-a07c-7de81a8960c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_0d1c6072-c328-4014-b621-22e14e7b13a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_91f904da-abb2-4be1-a703-1c5fa064f76a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_0d1c6072-c328-4014-b621-22e14e7b13a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_aa6477bb-6e37-491c-94c0-c99ba344d5e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_91f904da-abb2-4be1-a703-1c5fa064f76a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_aa6477bb-6e37-491c-94c0-c99ba344d5e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.biocryst.com/role/CollaborativeandOtherRelationshipsDetails" xlink:type="simple" xlink:href="bcrx-20220930.xsd#CollaborativeandOtherRelationshipsDetails"/>
  <link:presentationLink xlink:role="http://www.biocryst.com/role/CollaborativeandOtherRelationshipsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_f98f56d9-95e7-4c5c-95e9-fb0574956dfc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_2051724d-1899-45ee-a3e3-ff5cc6e495b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_f98f56d9-95e7-4c5c-95e9-fb0574956dfc" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_2051724d-1899-45ee-a3e3-ff5cc6e495b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_9c814e58-a043-4ef7-a93f-a6e52fecd5c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_2051724d-1899-45ee-a3e3-ff5cc6e495b9" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_9c814e58-a043-4ef7-a93f-a6e52fecd5c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_140e9d38-79c2-4136-996b-6040bf1b1bd9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_9c814e58-a043-4ef7-a93f-a6e52fecd5c7" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_140e9d38-79c2-4136-996b-6040bf1b1bd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_NationalInstituteOfAllergyAndInfectiousDiseasesMember_b8121800-cac2-43d6-9b4d-43a901a28cdd" xlink:href="bcrx-20220930.xsd#bcrx_NationalInstituteOfAllergyAndInfectiousDiseasesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_140e9d38-79c2-4136-996b-6040bf1b1bd9" xlink:to="loc_bcrx_NationalInstituteOfAllergyAndInfectiousDiseasesMember_b8121800-cac2-43d6-9b4d-43a901a28cdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_UABMember_4535ab85-238e-4b21-a7a3-d0b36139349a" xlink:href="bcrx-20220930.xsd#bcrx_UABMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_140e9d38-79c2-4136-996b-6040bf1b1bd9" xlink:to="loc_bcrx_UABMember_4535ab85-238e-4b21-a7a3-d0b36139349a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_6806b090-60c5-4c77-88c6-ae1aa0f7d864" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_2051724d-1899-45ee-a3e3-ff5cc6e495b9" xlink:to="loc_us-gaap_TypeOfArrangementAxis_6806b090-60c5-4c77-88c6-ae1aa0f7d864" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_369b6cb6-4482-475e-9ffb-90168bb0a965" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_6806b090-60c5-4c77-88c6-ae1aa0f7d864" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_369b6cb6-4482-475e-9ffb-90168bb0a965" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_BaseContractMember_e1ee616b-d2ff-46ac-84ff-9342a8de897d" xlink:href="bcrx-20220930.xsd#bcrx_BaseContractMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_369b6cb6-4482-475e-9ffb-90168bb0a965" xlink:to="loc_bcrx_BaseContractMember_e1ee616b-d2ff-46ac-84ff-9342a8de897d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AdditionalDevelopmentOptionsMember_99f500cb-c787-400d-8bb3-2b843c330d5c" xlink:href="bcrx-20220930.xsd#bcrx_AdditionalDevelopmentOptionsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_369b6cb6-4482-475e-9ffb-90168bb0a965" xlink:to="loc_bcrx_AdditionalDevelopmentOptionsMember_99f500cb-c787-400d-8bb3-2b843c330d5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ASPRBARDAContractMember_d881a3fa-96a4-43f1-b549-226a6a5560c1" xlink:href="bcrx-20220930.xsd#bcrx_ASPRBARDAContractMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_369b6cb6-4482-475e-9ffb-90168bb0a965" xlink:to="loc_bcrx_ASPRBARDAContractMember_d881a3fa-96a4-43f1-b549-226a6a5560c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AECOMAndIRLMember_b5c762a0-4809-43d2-a53c-2ef3257d1c0c" xlink:href="bcrx-20220930.xsd#bcrx_AECOMAndIRLMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_369b6cb6-4482-475e-9ffb-90168bb0a965" xlink:to="loc_bcrx_AECOMAndIRLMember_b5c762a0-4809-43d2-a53c-2ef3257d1c0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_b894e983-fc7c-402b-a50f-d41f47da76c4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_2051724d-1899-45ee-a3e3-ff5cc6e495b9" xlink:to="loc_srt_CounterpartyNameAxis_b894e983-fc7c-402b-a50f-d41f47da76c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_32937a1f-7fd7-46fc-a35a-155bf135039e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_b894e983-fc7c-402b-a50f-d41f47da76c4" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_32937a1f-7fd7-46fc-a35a-155bf135039e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_USDepartmentOfHealthAndHumanServicesMember_ca1b3150-ed90-4813-8deb-a87439c1bdc7" xlink:href="bcrx-20220930.xsd#bcrx_USDepartmentOfHealthAndHumanServicesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_32937a1f-7fd7-46fc-a35a-155bf135039e" xlink:to="loc_bcrx_USDepartmentOfHealthAndHumanServicesMember_ca1b3150-ed90-4813-8deb-a87439c1bdc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ToriiPharmaceuticalCoMember_f81944ad-e892-4fb4-acae-9fd08eff710d" xlink:href="bcrx-20220930.xsd#bcrx_ToriiPharmaceuticalCoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_32937a1f-7fd7-46fc-a35a-155bf135039e" xlink:to="loc_bcrx_ToriiPharmaceuticalCoMember_f81944ad-e892-4fb4-acae-9fd08eff710d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_9529642e-df1a-4046-8ea2-a7ba2c2f3456" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_2051724d-1899-45ee-a3e3-ff5cc6e495b9" xlink:to="loc_srt_ProductOrServiceAxis_9529642e-df1a-4046-8ea2-a7ba2c2f3456" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_d6818e00-2e4f-4734-bddf-fe7ae78e8035" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_9529642e-df1a-4046-8ea2-a7ba2c2f3456" xlink:to="loc_srt_ProductsAndServicesDomain_d6818e00-2e4f-4734-bddf-fe7ae78e8035" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RAPIVABMember_2ee436af-0c64-4ffc-b081-dce1a2fadfae" xlink:href="bcrx-20220930.xsd#bcrx_RAPIVABMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_d6818e00-2e4f-4734-bddf-fe7ae78e8035" xlink:to="loc_bcrx_RAPIVABMember_2ee436af-0c64-4ffc-b081-dce1a2fadfae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_a76811cd-d179-45da-8d0d-05c1df07f01c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_2051724d-1899-45ee-a3e3-ff5cc6e495b9" xlink:to="loc_srt_RangeAxis_a76811cd-d179-45da-8d0d-05c1df07f01c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_830f2664-65c6-41ff-9c6b-c685861e0374" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_a76811cd-d179-45da-8d0d-05c1df07f01c" xlink:to="loc_srt_RangeMember_830f2664-65c6-41ff-9c6b-c685861e0374" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_6bc98784-5cd8-4396-ae22-97bcb2bb49e4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_830f2664-65c6-41ff-9c6b-c685861e0374" xlink:to="loc_srt_MinimumMember_6bc98784-5cd8-4396-ae22-97bcb2bb49e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_fbd6bd69-74b4-4672-a536-f5f70a635df1" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_830f2664-65c6-41ff-9c6b-c685861e0374" xlink:to="loc_srt_MaximumMember_fbd6bd69-74b4-4672-a536-f5f70a635df1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_2051724d-1899-45ee-a3e3-ff5cc6e495b9" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ExpectedReceivableFromAwardsForResearchAndDevelopmentContracts_518b7775-a263-4c2f-b6aa-5906f4baa44b" xlink:href="bcrx-20220930.xsd#bcrx_ExpectedReceivableFromAwardsForResearchAndDevelopmentContracts"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_ExpectedReceivableFromAwardsForResearchAndDevelopmentContracts_518b7775-a263-4c2f-b6aa-5906f4baa44b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_CollaborativeAgreementContractCovenantMaximumAmountOfFunding_4052dd3d-01df-468d-9e75-044bd49b06b4" xlink:href="bcrx-20220930.xsd#bcrx_CollaborativeAgreementContractCovenantMaximumAmountOfFunding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_CollaborativeAgreementContractCovenantMaximumAmountOfFunding_4052dd3d-01df-468d-9e75-044bd49b06b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_CollaborativeAgreementContractValue_f9ba83a3-e76f-450e-b517-2ca7ff19f07c" xlink:href="bcrx-20220930.xsd#bcrx_CollaborativeAgreementContractValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_CollaborativeAgreementContractValue_f9ba83a3-e76f-450e-b517-2ca7ff19f07c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GovernmentContractReceivable_03ed14b1-5ca8-4921-9738-c00ca9c0617d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GovernmentContractReceivable"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_us-gaap_GovernmentContractReceivable_03ed14b1-5ca8-4921-9738-c00ca9c0617d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ProceedsFromAwardsForResearchAndDevelopmentContracts_ee044f47-51d4-4107-b2f2-90646a7a986b" xlink:href="bcrx-20220930.xsd#bcrx_ProceedsFromAwardsForResearchAndDevelopmentContracts"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_ProceedsFromAwardsForResearchAndDevelopmentContracts_ee044f47-51d4-4107-b2f2-90646a7a986b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_MaximumNumberOfProductsPermittedToBeObtainedDoses_0f12c569-c0c3-4aa4-9722-0e072384d0fc" xlink:href="bcrx-20220930.xsd#bcrx_MaximumNumberOfProductsPermittedToBeObtainedDoses"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_MaximumNumberOfProductsPermittedToBeObtainedDoses_0f12c569-c0c3-4aa4-9722-0e072384d0fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_NumberOfProductsObtainedDoses_aed9fc07-9447-4289-a97d-c78077e42b0f" xlink:href="bcrx-20220930.xsd#bcrx_NumberOfProductsObtainedDoses"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_NumberOfProductsObtainedDoses_aed9fc07-9447-4289-a97d-c78077e42b0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_ContractTerm_fe5bff1c-980a-4162-9f9c-7948dc232243" xlink:href="bcrx-20220930.xsd#bcrx_ContractTerm"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_ContractTerm_fe5bff1c-980a-4162-9f9c-7948dc232243" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollaborators_7c70c8a4-ac1d-4ea9-a4f9-a5a6d25ef4a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromCollaborators"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_us-gaap_ProceedsFromCollaborators_7c70c8a4-ac1d-4ea9-a4f9-a5a6d25ef4a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_08f9a4f2-d7ae-40e0-a1e9-dea2322a2add" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax_08f9a4f2-d7ae-40e0-a1e9-dea2322a2add" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PotentialMilestonePaymentsReceivableIfRegulatoryApprovalBeforeMilestone_ca182020-3a40-49fb-83a6-48e0d1312621" xlink:href="bcrx-20220930.xsd#bcrx_PotentialMilestonePaymentsReceivableIfRegulatoryApprovalBeforeMilestone"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_PotentialMilestonePaymentsReceivableIfRegulatoryApprovalBeforeMilestone_ca182020-3a40-49fb-83a6-48e0d1312621" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyRateIfMaintainsSakigakeDesignation_496080e9-c3e1-47d8-9665-3b345dea3ca1" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyRateIfMaintainsSakigakeDesignation"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_RoyaltyRateIfMaintainsSakigakeDesignation_496080e9-c3e1-47d8-9665-3b345dea3ca1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_MaximumCustomaryReductionOnRoyaltyRate_43d25527-c4e0-4f5c-a3a6-e4d8bc67cacd" xlink:href="bcrx-20220930.xsd#bcrx_MaximumCustomaryReductionOnRoyaltyRate"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_MaximumCustomaryReductionOnRoyaltyRate_43d25527-c4e0-4f5c-a3a6-e4d8bc67cacd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RoyaltyPaymentsReceivableExpirationTermFromFirstCommercial_efcfd237-eebb-4b68-86da-f801263d3942" xlink:href="bcrx-20220930.xsd#bcrx_RoyaltyPaymentsReceivableExpirationTermFromFirstCommercial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_RoyaltyPaymentsReceivableExpirationTermFromFirstCommercial_efcfd237-eebb-4b68-86da-f801263d3942" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_MilestonePaymentMinimum_384fbdbe-f4d0-46d6-bb39-00ba69322e14" xlink:href="bcrx-20220930.xsd#bcrx_MilestonePaymentMinimum"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_MilestonePaymentMinimum_384fbdbe-f4d0-46d6-bb39-00ba69322e14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_MilestonePaymentMaximum_2cce2a98-0bfa-4072-b5c0-4d41f81f6fb9" xlink:href="bcrx-20220930.xsd#bcrx_MilestonePaymentMaximum"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_MilestonePaymentMaximum_2cce2a98-0bfa-4072-b5c0-4d41f81f6fb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualLicenseFeeMinimum_9a597029-feba-4d31-b1f2-910243bef264" xlink:href="bcrx-20220930.xsd#bcrx_AnnualLicenseFeeMinimum"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_AnnualLicenseFeeMinimum_9a597029-feba-4d31-b1f2-910243bef264" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_AnnualLicenseFeeMaximum_e058715f-43d2-434b-ae24-a89642626efa" xlink:href="bcrx-20220930.xsd#bcrx_AnnualLicenseFeeMaximum"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_AnnualLicenseFeeMaximum_e058715f-43d2-434b-ae24-a89642626efa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_PeriodOfAgreement_45714209-3e8e-436a-98a1-a0fbf52703e8" xlink:href="bcrx-20220930.xsd#bcrx_PeriodOfAgreement"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_PeriodOfAgreement_45714209-3e8e-436a-98a1-a0fbf52703e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_bcrx_RenewablePeriodOfAgreement_3d1d28fd-5f56-4a46-9e11-8bb80c97bc77" xlink:href="bcrx-20220930.xsd#bcrx_RenewablePeriodOfAgreement"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersLineItems_84ab1115-18fd-482a-ad95-e4a2fb05bb45" xlink:to="loc_bcrx_RenewablePeriodOfAgreement_3d1d28fd-5f56-4a46-9e11-8bb80c97bc77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
