Maturing in one year or less Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One Interest and other income Interest and other income The amount of interest income and other income (loss) recognized during the period. Included in this element is interest derived from investments in debt securities, cash and cash equivalents, and other investments which reflect the time value of money or transactions in which the payments are for the use or forbearance of money and other income (loss) from ancillary business-related activities (that is, excluding major activities considered part of the normal operations of the business). Term B And C Loan Term B And C Loan [Member] Term B And C Loan Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Total lease payments Lessee, Operating Lease, Liability, to be Paid Long-term debt, gross Long-Term Debt, Gross Non-cash interest expense on royalty financing obligations and secured term loan and amortization of debt issuance costs Non-cash interest expense on royalty financing obligations and secured term loan and amortization of debt issuance costs The amount of noncash interest expense and amortization of debt issuance costs. Entity Address, Postal Zip Code Entity Address, Postal Zip Code Thereafter Lessee Operating Lease Liability To Be Paid After Year Four Amount of lessee's undiscounted obligation for lease payment for operating lease due after fourth fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach). Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Debt Instrument [Axis] Debt Instrument [Axis] Incentive Plan Incentive Plan [Member] Represents Incentive Plan. MidCap Financial Services, LLC MidCap Financial Services, LLC [Member] Represents MidCap Financial Services, LLC entity. Receivable [Domain] Receivable [Domain] Collaborative and other revenues Collaborative and Other Research and Development [Member] Information pertaining to Collaborative and other research and development. Additional paid-in capital Additional Paid in Capital Inventory adjustments Inventory Adjustments Financial Instruments [Domain] Financial Instruments [Domain] Debt instrument, basis spread on variable rate Debt Instrument, Basis Spread on Variable Rate Statistical Measurement [Domain] Statistical Measurement [Domain] Proceeds from issuance of debt Proceeds from Issuance of Debt Exercise of stock options, net (in shares) Options outstanding, stock option awards exercised (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Debt instrument, LIBOR cap Debt Instrument Libor Cap Maximum LIBOR interest rate for debt instrument. Employee Stock Purchase Plan Employee Stock Purchase Plan [Member] Employee stock purchase plan, (ESPP). Weighted average discount rate Operating Lease, Weighted Average Discount Rate, Percent Debt instrument, interest rate, stated percentage Debt Instrument, Interest Rate, Stated Percentage Share-Based Payment Arrangement [Abstract] Annual Net Sales Over $550,000 Annual Net Sales Over $550,000 [Member] Represents annual net sales over $550,000. Maximum number of shares per employee, amount Share Based Compensation Arrangement By Share Based Payment Award Maximum Number Of Shares Per Employee Amount Represents share-based compensation arrangement by share-based payment award maximum value per employee amount. Athyrium Athyrium [Member] Represents Athyrium Opportunities III Co-Invest 1 LP (“Athyrium”). Net loss Net loss Net Income (Loss) Attributable to Parent Lessee, Lease, Description [Table] Lessee, Lease, Description [Table] Antidilutive securities excluded from computation of earnings per share, amount (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Royalty purchase agreement, royalties, percentage of purchase price Royalty Purchase Agreement Royalties Percentage Of Purchase Price The percentage of the purchase price under the royalty purchase agreement. Outside of U.S. RAPIVAB [Member] Represents RAPIVAB product. Subsequent Event Type [Axis] Subsequent Event Type [Axis] Legal Entity Type of Counterparty [Domain] Legal Entity Type of Counterparty [Domain] Equity Component [Domain] Equity Component [Domain] Subsequent Event Type [Domain] Subsequent Event Type [Domain] Annual Net Sales Range [Domain] Annual Net Sales Range [Domain] Annual Net Sales Range Other collaborations Other Collaborations [Member] Other Collaborations JPR Royalty Sub LLC JPR Royalty Sub LLC [Member] Represents JPR Royalty Sub LLC. Term Loan A and B Drawn Term Loan A and B Drawn [Member] Represents term loan A and B drawn. Award vesting rights, percentage Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage Lease Obligations Lessee, Operating Leases [Text Block] Deferred financing costs Payments of Financing Costs Awards available, stock option awards cancelled (in shares) Awards available, stock option awards cancelled (in shares) Share based compensation arrangement by share based payment award options forfeitures in period awards available. Lessee, Lease, Description [Line Items] Lessee, Lease, Description [Line Items] Billed Billed Revenues [Member] Plan Name [Axis] Plan Name [Axis] Estimated Fair Value Estimated Fair Value Debt Securities, Available-for-Sale Plan Name [Domain] Plan Name [Domain] 2023 (remaining) Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Entity Address, State or Province Entity Address, State or Province Pharmakon Advisors, LP Pharmakon Advisors, LP [Member] Pharmakon Advisors, LP Shares issued, price per share (in usd per share) Shares Issued, Price Per Share Award Type [Axis] Award Type [Axis] Royalty purchase agreement, royalties, purchase price, amount Royalty Purchase Agreement Royalties Purchase Price Amount The amount of the purchase price under the royalty purchase agreement. PIK Interest Payment is Made PIK Interest Payment is Made [Member] Represents PIK interest payment is made. BCX10013 BCX10013 [Member] BCX10013 Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Lease financing obligation Operating Lease, Liability, Current Debt instrument, LIBOR floor Debt Instrument Libor Floor Minimum LIBOR interest rate for debt instrument. Accounts, Notes, Loans and Financing Receivable [Line Items] Accounts, Notes, Loans and Financing Receivable [Line Items] Significant Accounting Policies and Concentrations of Risk [Table] Significant Accounting Policies and Concentrations of Risk [Table] Significant Accounting Policies and Concentrations of Risk Fair Value of the Company's Investments by Type Debt Securities, Available-for-Sale [Table Text Block] Long-term investment maturity, minimum (in years) Long term Investment Maturity Minimum Represents long term investment maturity minimum. Expenses: Costs and Expenses [Abstract] Lender Name [Axis] Lender Name [Axis] Receivables [Abstract] Legal Entity [Axis] Legal Entity [Axis] Secured term loan Long-Term Debt, Excluding Current Maturities Certificates of deposit Certificates of Deposit [Member] Weighted average remaining lease term (in years) Operating Lease, Weighted Average Remaining Lease Term Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities [Abstract] Royalty purchase agreement, royalties, percentage of annual net sales, based on reduction in sales Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales Based On Reduction In Sales he percentage of annual net sales of royalties to be paid under the royalty purchase agreement if sales are less than specified. Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Investments Debt Securities, Available-for-Sale, Current Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued Document Type Document Type Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate [Member] Property, plant and equipment, useful life (in years) Property, Plant and Equipment, Useful Life Options outstanding, stock option awards cancelled (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period Debt Debt Disclosure [Text Block] Product and Service [Domain] Product and Service [Domain] Annual Net Sales Between $150,000 and $230,000 Annual Net Sales Between $150,000 and $230,000 [Member] Represents annual net sales between $150,000 and $230,000. Entity Shell Company Entity Shell Company Investments [Abstract] Financing receivable, committed, remaining amount Financing Receivable, Committed, Remaining Amount Financing Receivable, Committed, Remaining Amount Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Statement of Financial Position [Extensible Enumeration] Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Statement of Financial Position [Extensible Enumeration] Collateral for Credit Collateral for Credit [Member] Restricted cash and cash equivalents required to maintain as collateral for a letter of credit. 2024 Lessee, Operating Lease, Liability, to be Paid, Year One Financial Instrument [Axis] Financial Instrument [Axis] Debt instrument, exit fee, percentage of principal Debt Instrument Exit Fee Percentage of Principal The percentage of principal for exit fee of the debt instrument. Other revenues Other Income From Contract With Customer [Member] Other Income From Contract With Customer Subsequent Event Subsequent Event [Member] Compensation cost expected to be recognized year two Employee Service Share Based Compensation Nonvested Awards Compensation Cost Expected to be Recognized Year Two Employee service share based compensation nonvested awards compensation cost expected to be recognized year two. Document Period End Date Document Period End Date Share-Based Payment Arrangement, Tranche One Share-Based Payment Arrangement, Tranche One [Member] The Company Description of Company [Policy Text Block] The description of company policy. Term B Loan Term B Loan [Member] Represents term B loan. Trade Receivables Trade Receivables [Text Block] The entire disclosure for trade receivables. Total assets Assets Debt Disclosure [Abstract] Schedule of the Maturity of Investments Debt Securities, Held-to-Maturity [Table Text Block] Compensation cost expected to be recognized next year Employee Service Share-Based Compensation Nonvested Awards Compensation Cost Expected to be Recognized Next Year Employee service share-based compensation nonvested awards compensation cost expected to be recognized next year. Performance Shares Performance Shares [Member] Trade Accounts Receivable Trade Accounts Receivable [Member] Summary of Receivables Schedule of Receivables from Collaborations [Table Text Block] Tabular disclosure representing receivables from collaborations. Accrued expenses Accrued Liabilities, Current Weighted average exercise price of stock option awards exercised (in usd per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Accounting Policies [Abstract] Accounting Policies [Abstract] Long-term investments Long-Term Investments Stockholders' Equity Note [Abstract] U.S. Geographic Distribution, Domestic [Member] Interest expense, debt, total Interest Expense, Debt Amortization of debt financing costs and original issue discounts Amortization Of Debt Financing Costs And Original Issue Discounts The amount of amortization of debt financing costs and original issue discounts. Loss before income taxes Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Stockholders’ equity: Stockholders' Equity Attributable to Parent [Abstract] Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Performance-based Restricted Stock Units Performance-based Restricted Stock Units [Member] Represents performance-based restricted stock units. Foreign currency losses, net Gain (Loss) on Foreign Currency Derivative Instruments Not Designated as Hedging Instruments Weighted Average Assumptions for Stock Option Awards Granted to Employees and Directors Under the Plans Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Disclosure of Share-Based Compensation Arrangements by Share-Based Payment Award Disclosure of Share-Based Compensation Arrangements by Share-Based Payment Award [Table Text Block] Cash and Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Award Type [Domain] Award Type [Domain] Stock option awards remaining contractual term (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Trade Receivables Receivable [Policy Text Block] Computer Equipment Computer Equipment [Member] Finished goods Inventory, Finished Goods, Gross Revenues Revenue from Contract with Customer, Including Assessed Tax Entity Registrant Name Entity Registrant Name Stock issued during period, shares, new issues (in shares) Stock Issued During Period, Shares, New Issues 2021 RPI Royalty Agreement 2021 RPI Royalty Agreement [Member] Information on 2021 RPI Royalty Agreement. Debt instrument, prepayment fee, percentage of accrued interest Debt Instrument Prepayment Fee Percentage of Accrued Interest The percentage of interest that would have accrued on principal voluntary paid for prepayment fee of the debt instrument. Collaborative and Other Relationships [Line Items] Research and Development Arrangement, Contract to Perform for Others [Line Items] Subsequent Events Subsequent Events [Text Block] Weighted Average Exercise Price Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price [Abstract] Maximum number of products, doses Maximum Number Of Products Permitted To Be Obtained Doses Information on the maximum number of doses of RAPIVAB permitted under the contract. Expected Dividend Yield Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate Entity Address, City or Town Entity Address, City or Town Royalty revenues paid and payable Royalty revenues paid and payable Represents royalties revenues paid and payable. Leases [Abstract] Annual Net Sales Over $3 Million Annual Net Sales Over $3 Billions [Member] Represents annual net sales over $3 billions. Geographic Distribution [Domain] Geographic Distribution [Domain] Debt instrument, covenant, minimum unrestricted cash and cash equivalents Debt Instrument Covenant Minimum Unrestricted Cash and Cash Equivalents The minimum amount of unrestricted cash and cash equivalents required under the covenant of the debt instrument. Annual Net Sales Between $350,000 and $550,000 Annual Net Sales Between $350,000 and $550,000 [Member] Represents annual net sales between $350,000 and $550,000. Minimum Minimum [Member] Restricted cash Restricted Cash and Cash Equivalents, Current Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Entity Emerging Growth Company Entity Emerging Growth Company Common stock par value (in usd per share) Common Stock, Par or Stated Value Per Share Inventory obsolescence Inventory Write-down After Fourth Anniversary After Fourth Anniversary [Member] Represents after the fourth anniversary. Outside of U.S. Geographic Distribution, Foreign [Member] Accounting Standards Update [Axis] Accounting Standards Update [Axis] Torii Pharmaceutical Co. Torii Pharmaceutical Co. [Member] Information related to Torii Pharmaceutical Co., Ltd. Trading Symbol Trading Symbol Entity File Number Entity File Number Research and development Research and Development Expense Annual Net Sales Under $350,000 Annual Net Sales Under $350,000 [Member] Represents annual net sales under $350,000. Deferred revenue Deferred Revenue, Current Percentage of common stock shares, ending Percentage of Common Stock Shares Ending Represents percentage of common stock shares ending. Title of Individual [Axis] Title of Individual [Axis] Royalty purchase agreement, royalties, percentage of annual net sales Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales The percentage of annual net sales for royalties to be paid under the royalty purchase agreement. Marketable Securities [Line Items] Marketable Securities [Line Items] Awards available, restricted stock awards granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Restricted Stock Units (RSUs) Restricted Stock Units (RSUs) [Member] Use of Estimates Use of Estimates, Policy [Policy Text Block] Thirty-six Equal Monthly Installments Thirty-six Equal Monthly Installments [Member] Information on the vesting period. Raw materials Inventory, Raw Materials, Gross Accounts payable and accrued expenses Increase (Decrease) in Accounts Payable London Interbank Offered Rate (LIBOR) London Interbank Offered Rate (LIBOR) [Member] Subsequent Events [Abstract] Investments Investments and Other Noncurrent Assets [Text Block] Non-employee Directors Non-employee Directors [Member] Represents non-employee directors of the company. Performance-based restricted stock unit awards issued (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Granted Credit Facility [Domain] Credit Facility [Domain] Royalty Royalty The amount of royalty expense (reversal of expense) during the period. Basic net loss per common share (in usd per share) Earnings Per Share, Basic Compensation cost expected to be recognized for remainder of fiscal year Employee Service Share Based Compensation Nonvested Awards Compensation Cost Expected to be Recognized for Remainder of Fiscal Year Employee service share based compensation nonvested awards compensation cost expected to be recognized for remainder of fiscal year. 2026 Lessee, Operating Lease, Liability, to be Paid, Year Three Annual Net Sales Between $1.5 and $3 Millions Annual Net Sales Between $1.5 and $3 Billions [Member] Represents annual net sales between $1.5 and $3 billions. Reclassification from accumulated other comprehensive income, current period, before tax Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost, Excluding Accrued Interest, after Allowance for Credit Loss Inventory Inventory, Policy [Policy Text Block] Counterparty Name [Domain] Counterparty Name [Domain] Trade Receivables [Table] Schedule of Accounts, Notes, Loans and Financing Receivable [Table] Total stockholders’ deficit Balance Balance Stockholders' Equity Attributable to Parent Cash, cash equivalents and restricted cash at beginning of period Cash, cash equivalents and restricted cash at end of period Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations Vesting [Domain] Vesting [Domain] Entity Interactive Data Current Entity Interactive Data Current Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Accrued Interest Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss Accumulated Deficit Retained Earnings [Member] Common Stock Common Stock [Member] Receivable Type [Axis] Receivable Type [Axis] Aggregate Lease Expense Under Operating Leases Lease, Cost [Table Text Block] Number of common stock shares available for purchase (in shares) Awards available, beginning balance (in shares) Awards available, ending balance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Income Taxes Income Tax, Policy [Policy Text Block] Revenue Recognition Revenue [Policy Text Block] Statement [Table] Statement [Table] Financing receivable, committed, amount drawn Financing Receivable, Committed, Amount Drawn Financing Receivable, Committed, Amount Drawn Effective interest rate Debt Instrument, Interest Rate, Effective Percentage Total receivables Receivables, Net, Current Document Quarterly Report Document Quarterly Report Furniture and Fixtures Furniture and Fixtures [Member] Liabilities: Operating Lease, Liability [Abstract] Lease financing obligation Operating Lease, Liability, Noncurrent Statistical Measurement [Axis] Statistical Measurement [Axis] Line of Credit Facility, Lender [Domain] Line of Credit Facility, Lender [Domain] Accumulated deficit Retained Earnings (Accumulated Deficit) Trade receivables Accounts Receivable, after Allowance for Credit Loss, Current Equity Components [Axis] Equity Components [Axis] Aggregate lease expense Aggregate Lease Expense Aggregate Lease Expense Green Cross Corporation Green Cross Corporation [Member] Represents Green Cross Corporation. Debt instrument, commitment fee percentage Debt Instrument Commitment Fee Percentage The commitment fee percentage of the debt instrument. Accumulated Other Comprehensive Income Comprehensive Income, Policy [Policy Text Block] Document Fiscal Year Focus Document Fiscal Year Focus Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Statement [Line Items] Statement [Line Items] Royalty rate if maintains sakigake designation Royalty Rate If Maintains Sakigake Designation The percent of net sales that the company will receive if berotralstat maintains its Sakigake designation during the PMDA review. Between the Third and Fourth Anniversaries Between the Third and Fourth Anniversaries [Member] Represents after the third anniversary and before the fourth anniversary. Variable Rate [Domain] Variable Rate [Domain] Selling, general and administrative Selling, General and Administrative Expense Derivative, floor interest rate Derivative, Floor Interest Rate Operating lease assets, net Operating Lease, Right-of-Use Asset Gross Unrealized Losses Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Product sales, net Product [Member] Accumulated Other Comprehensive Income AOCI Attributable to Parent [Member] Acquisitions of property and equipment Payments to Acquire Productive Assets Document Transition Report Document Transition Report Local Phone Number Local Phone Number Inducement Plan Inducement Plan [Member] Related to the Inducement Plan. Loss from operations Operating Income (Loss) Stock Plan Activities Share-Based Payment Arrangement, Activity [Table Text Block] Inventory Increase (Decrease) in Inventories Legal Entity of Counterparty, Type [Axis] Legal Entity of Counterparty, Type [Axis] Recently Adopted Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Debt Instrument libor interest rate Debt Instrument Libor Interest Rate Debt Instrument Libor Interest Rate Common stock, shares, outstanding (in shares) Common Stock, Shares, Outstanding Total inventory Inventory, Gross Long-Lived Tangible Asset [Axis] Long-Lived Tangible Asset [Axis] Schedule of Royalty Financing Obligations Royalty Financing Obligations [Table Text Block] Tabular disclosure for royalty financing obligations. Operating lease, right-of-use asset, accumulated amortization Operating Lease Right of use Asset Accumulated Amortization Amount of accumulated amortization on lessee's right to use underlying asset under operating lease. Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Income tax expense Income Tax Expense (Benefit) Equity Disclosure [Table] Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Property and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Awards available, stock option awards granted (in shares) Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Awards Available Represents share based compensation arrangement by share based payment award options grants in period awards available. Preferred stock par value (in usd per share) Preferred Stock, Par or Stated Value Per Share 2027 Lessee, Operating Lease, Liability, to be Paid, Year Four Income Statement [Abstract] Income Statement [Abstract] Performance-based stock options issued in period (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Additional Paid-In Capital Additional Paid-in Capital [Member] Document Fiscal Period Focus Document Fiscal Period Focus Cost of product sales Cost of Goods and Services Sold Term Loans Term Loans [Member] Term Loans Weighted average shares outstanding, diluted (in shares) Weighted Average Number of Shares Outstanding, Diluted Summary of Inventories Schedule of Inventory, Current [Table Text Block] Expected Life in Years Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Maximum number of shares per employee (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Number of Shares Per Employee Billing Status, Type [Axis] Billing Status, Type [Axis] Common stock, $0.01 par value; shares authorized - 450,000; shares issued and outstanding – 188,883 as of March 31, 2023 and 187,906 as of December 31, 2022 Common Stock, Value, Issued Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Maximum customary reduction on royalty rate Maximum Customary Reduction On Royalty Rate The maximum percentage of customary reductions allowed on royalty rate. Financing receivable, committed Financing Receivable, Committed Financing Receivable, Committed Weighted average grant date fair value (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Balance Sheets of the Company's Operating Leases Lessee, Operating Lease, Assets and Liabilities [Table Text Block] Tabular disclosure of the assets and liabilities of the lessee's operating lease. Term A Loan Term A Loan [Member] Represents term A loan. Term Loans A, B and C Drawn and Cure Right Exercised Term Loans A, B and C Drawn and Cure Right Exercised [Member] Represents term loans A, B and C drawn and the Cure Right has been exercised. Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Term C Loan Term C Loan [Member] Represents term C loan. Maturity period of short term investment (in months) Maturity Period Of Short Term Investment Maturity period of short term investment. Proceeds from issuance of long-term debt, total Proceeds from Issuance of Long-Term Debt Net proceeds from common stock issued under stock-based compensation plans Proceeds from Stock Options Exercised Common stock, shares, issued (in shares) Common Stock, Shares, Issued Amendment Flag Amendment Flag Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities Debt instrument, face amount Debt Instrument, Face Amount The 2021 RPI Royalty Purchase Agreement The 2021 RPI Royalty Purchase Agreement [Member] Represents the 2021 RPI Royalty Purchase Agreement. Investments Investment, Policy [Policy Text Block] Other comprehensive income Other Comprehensive Income (Loss), Net of Tax OMERS Royalty Agreement OMERS Royalty Agreement [Member] Information on OMERS Royalty Agreement. Employee stock purchase plan sales, net Stock Issued During Period, Value, Employee Stock Purchase Plan Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Royalty Monetizations [Line Items] Royalty Monetizations [Line Items] Royalty Monetizations Annual Net Sales Range [Axis] Annual Net Sales Range [Axis] Annual Net Sales Range Gross Unrealized Gains Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax Entity Current Reporting Status Entity Current Reporting Status Other assets Other Assets, Noncurrent Annual Net Sales Under $150,000 Annual Net Sales Under $150,000 [Member] Represents annual net sales under $150,000. Depreciation and amortization Depreciation, Depletion and Amortization Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] PhaRMA Notes PhaRMA Notes Member] Represents PhaRMA notes. Lessee, operating lease, term of contract (in years) Lessee, Operating Lease, Term of Contract U.S. Department of Health and Human Services, net US Department of Health and Human Services [Member] United States department of health and human services. Employee stock purchase plan sales, net (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Counterparty Name [Axis] Counterparty Name [Axis] Options outstanding, beginning balance (in shares) Options outstanding, ending balance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Debt instrument, unamortized discount (premium) and debt issuance costs, net, total Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Effect of exchange rate on cash, cash equivalents, and restricted cash Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Continuing Operations Property and equipment, net Property, Plant and Equipment, Net Operating lease, payments Operating Lease, Payments Royalty purchase agreement, royalties, percentage of sublicense revenue in other markets Royalty Purchase Agreement Royalties Percentage of Sublicense Revenue In Other Markets The percentage of sublicense revenue in other markets of royalties to be paid under the royalty purchase agreement. Compensation cost expected to be recognized year three Employee Service Share Based Compensation Nonvested Awards Compensation Cost Expected to be Recognized Year Three Employee service share based compensation nonvested awards compensation cost expected to be recognized year three. Share-Based Payment Arrangement, Option Share-Based Payment Arrangement, Option [Member] Title of Individual [Domain] Title of Individual [Domain] Expected Volatility Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate Exercise of stock options, net Stock Issued During Period, Value, Stock Options Exercised Awards available, restricted stock awards cancelled (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Long-term debt, total Long-Term Debt Common stock, shares authorized (in shares) Common Stock, Shares Authorized ORLADEYO ORLADEYO [Member] Represents ORLADEYO. Non-cash Interest expense on Royalty financing obligations Non-cash Interest expense on Royalty financing obligations Amount of non-cash interest expense on royalty financing obligation. Maximum Maximum [Member] Accumulated other comprehensive income Accumulated Other Comprehensive Income (Loss), Net of Tax Restricted Cash Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block] Royalty receivables from partners Royalty Receivables from Partners [Member] Information related to royalty receivables from partners. Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Work-in-process Inventory, Work in Process, Gross Deferred revenue Increase (Decrease) in Contract with Customer, Liability Total current assets Assets, Current Incentive Plan and Inducement Plan Incentive Plan and Inducement Plan [Member] Represents the incentive and inducement plans. Other assets [extensible enumeration] Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Senior Credit Facility Senior Credit Facility [Member] Represents senior credit facility. Credit facilities provide capital to borrowers without the need to structure a loan for each borrowing. Maturity period of high quality marketable securities (in years) Maturity Period Of High Quality Marketable Securities Represents maturity period of high quality marketable securities. Entity Small Business Entity Small Business Stockholders' Equity Stockholders' Equity Note Disclosure [Text Block] Revenues Revenues [Abstract] Purchase of investments Payments to Acquire Debt Securities, Available-for-Sale Cost of Product Sales Cost of Goods and Service [Policy Text Block] Significant Accounting Policies and Concentrations of Risk Significant Accounting Policies [Text Block] Total unrecognized compensation expense related to non-vested stock options and RSU awards Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount Options Outstanding Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward] Paid-in-kind interest Paid-in-Kind Interest Long-Lived Tangible Asset [Domain] Long-Lived Tangible Asset [Domain] Title of 12(b) Security Title of 12(b) Security Total operating expenses Costs and Expenses Subsequent Event [Line Items] Subsequent Event [Line Items] Options outstanding, stock option awards granted ( in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Net of Forfeitures Repayments of lines of credit Repayments of Lines of Credit Debt Instrument [Line Items] Debt Instrument [Line Items] Royalty financing obligations Balance Balance Royalty financing obligations Carrying amount as of the balance sheet date of obligations for future royalties. Total operating lease liabilities Total Operating Lease, Liability Obligations of U.S. Government and its agencies US Government Agencies Debt Securities [Member] Royalties Monetizations [Table] Royalties Monetizations [Table] Royalties Monetizations Stock-Based Compensation Share-Based Payment Arrangement [Policy Text Block] Assets: Assets: Information on operating lease right-of-use assets. Liabilities and Stockholders’ Deficit Liabilities and Equity [Abstract] Foreign currency translation adjustment Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Royalty purchase agreement, royalties, percentage of annual net sales in other markets Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales In Other Markets The percentage of annual net sales in other markets of royalties to be paid under the royalty purchase agreement. Weighted average exercise price of stock option awards granted (in usd per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Weighted average exercise price of stock option awards cancelled (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price Royalty Montizations [Roll Forward] Royalty Montizations [Roll Forward] Royalty Montizations Inventory, net Total inventory, net Inventory, Net Accounts payable Accounts Payable, Current Future Royalties Payable Future Royalties Payable [Member] Represents future royalties payable. Entity Filer Category Entity Filer Category Proceeds from issuance of common stock Proceeds from Issuance of Common Stock Weighted average shares outstanding, basic (in shares) Weighted Average Number of Shares Outstanding, Basic Restricted Cash and Cash Equivalents [Axis] Restricted Cash and Cash Equivalents [Axis] Share-based payment arrangement, expense Share-Based Payment Arrangement, Expense Royalty payments receivable, expiration term from first commercial (in years) Royalty Payments Receivable Expiration Term From First Commercial The expiration term of the royalty payments from first commercial date. Security Exchange Name Security Exchange Name Weighted average exercise price, beginning balance (in usd per share) Weighted average exercise price, ending balance (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Accounts receivable, after allowance for credit loss, total Accounts Receivable, after Allowance for Credit Loss Preferred stock, $0.01 par value; shares authorized - 5,000; no shares issued and outstanding Preferred Stock, Value, Issued Shares issued, price per share, closing price (in usd per share) Shares Issued Price Per Share Closing Price Information on the closing price. RPI 2021 and 2020 Intermediate Finance Trust RPI 2021 and 2020 Intermediate Finance Trust [Member] Represents RPI 2021 and 2020 Intermediate Finance Trust (RPI). OMERS Capital Markets OMERS Capital Markets [Member] Information on the rights of OMERS Capital Markets to receive certain royalty payments under the OMERS Royalty Purchase Agreement. Number of plans Share-Based Payment Arrangement, Number of Plans Share-Based Payment Arrangement, Number of Plans RPI 2019 Intermediate Finance Trust RPI 2019 Intermediate Finance Trust [Member] Represents RPI 2019 Intermediate Finance Trust (RPI).. Cover [Abstract] Long-Term Debt, Type [Axis] Schedule of Long-Term Debt Instruments [Table] Leases Lessee, Leases [Policy Text Block] Potential milestone payments receivable if regulatory approval before specified date Potential Milestone Payments Receivable If Regulatory Approval Before Milestone The amount of potential milestone payments receivable if regulatory approval is granted. Operating lease, liability, statement of financial position [extensible enumeration] Operating Lease, Liability, Statement of Financial Position [Extensible Enumeration] Geographic Distribution [Axis] Geographic Distribution [Axis] Number of product delivered, doses Number Of Product Delivered, Doses Number Of Product Delivered, Doses Significant Customers and Other Risks Concentration of Market Risk [Policy Text Block] Represents concentration of market risk policy. Contract term (in years) Contract Term Period of time between the contract date and its expiration. Share-Based Compensation Share-Based Payment Arrangement [Text Block] Average maturity period of high quality marketable securities (in months) Average Maturity Period Of High Quality Marketable Securities Average maturity period of high quality marketable securities. Other Supplemental Information Related to Leases Other Supplemental Information Related to Leases [Table Text Block] Other Supplemental Information Related to Leases Revenue Revenue from Contract with Customer [Text Block] Royalty purchase agreement, royalties, annual net sales payment threshold Royalty Purchase Agreement Royalties Annual Net Sales Payment Threshold Information on the maximum dollar amount of net sales allowed for royalty payments. Shares issued, common stock, premium Shares Issued Common Stock Premium Information on the amount of the common stock premium. Annual Net Sales Over $230,000 Annual Net Sales Over $230,000 [Member] Represents annual net sales over $230,000. Laboratory Equipment, Office Equipment and Software Laboratory Equipment, Office Equipment and Software [Member] Information pertaining to laboratory equipment, office equipment and software. Risk-Free Interest Rate Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Debt instrument, prepayment fee, percentage of principal voluntary payments Debt Instrument Prepayment Fee Percentage of Principal Voluntary Payments The percentage of principal paid voluntarily for prepayment fee of the debt instrument. Total liabilities and stockholders’ deficit Liabilities and Equity 2020 RPI Royalty Agreement 2020 RPI Royalty Agreement [Member] Information on 2020 RPI Royalty agreement. Amortization of debt issuance costs Amortization of Debt Issuance Costs Long-Term Debt, Type [Axis] Long-Term Debt, Type [Axis] Amortization of premium/discount on investments Amortization of premium/discount on investments Amount of amortization expense attributable to the discount and premium on investments. Receivables Increase (Decrease) in Receivables Organization, Consolidation and Presentation of Financial Statements [Abstract] Current Fiscal Year End Date Current Fiscal Year End Date Less imputed interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Vesting [Axis] Vesting [Axis] Diluted net loss per common share (in usd per share) Earnings Per Share, Diluted Sale of Stock [Domain] Sale of Stock [Domain] Advance Royalties [Abstract] Award vesting period (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period Royalty purchase agreement, royalties, percentage of annual net sales in key territories Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales In Key Territories The percentage of net sales in key territories for royalties to be paid under the royalty purchase agreement. Interest Expense and Royalty Financing Obligations Interest Expense and Royalty Financing Obligation [Policy Text Block] Disclosure of accounting policy for interest expense and royalty financing obligation. Stock-based compensation expense APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Total current liabilities Liabilities, Current 2025 Lessee, Operating Lease, Liability, to be Paid, Year Two Marketable Securities [Table] Marketable Securities [Table] Receivables Billing Status [Domain] Receivables Billing Status [Domain] Interest Expense and Deferred Financing Costs Interest Expense and Deferred Financing Costs [Policy Text Block] Represents interest expense and deferred financing costs. Expiration period (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period Vest Upon Successful Completion of Specific Development Milestones Vest Upon Successful Completion of Specific Development Milestones [Member] Represents vesting upon successful completion of specific development milestones. Corporate debt securities Corporate Debt Securities [Member] Compensation cost expected to be recognized year four Employee Service Share Based Compensation Nonvested Awards Compensation Cost Expected to be Recognized Year Four Employee service share based compensation nonvested awards compensation cost expected to be recognized year four. Maturities of Operating Lease Liabilities Lessee, Operating Lease, Liability, Maturity [Table Text Block] Entity Address, Address Line One Entity Address, Address Line One Unbilled Unbilled Revenues [Member] Product and Service [Axis] Product and Service [Axis] Royalty purchase agreement, royalties, maximum tiered profit share percentage on permitted sales in other markets Royalty Purchase Agreement Royalties Maximum Tiered Profit Share Percentage On Permitted Sales In Other Markets The percentage of net sales in certain markets for royalties to be paid under the royalty purchase agreement. Royalty Receivable Royalty Receivable [Member] Represents royalty receivable. Royalty Monetizations Royalty Monetization [Text Block] Royalty monetization. Debt Covenant Terms [Domain] Debt Covenant Terms [Domain] Debt Covenant Terms Equity Disclosure [Line Items] Subsidiary, Sale of Stock [Line Items] Interest expense Interest Expense Percentage of salary to purchase common stock, maximum Percentage of Salary To Purchase Common Stock Maximum Represents percentage of salary to purchase common stock maximum. Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Schedule of Research and Development Arrangement, Contract to Perform for Others [Table] Credit Facility [Axis] Credit Facility [Axis] Unrealized gain (loss) on available for sale investments OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax Sales and maturities of investments Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale Inventory valuation reserves Reserves Inventory Valuation Reserves Inventory Inventory Disclosure [Text Block] Common Stock Purchase Agreement with RPI Common Stock Purchase Agreement with RPI [Member] Information on the Common Stock Purchase Agreement with RPI. Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] Subsequent Event [Table] Subsequent Event [Table] Inventory Disclosure [Abstract] Awards Available Share-Based Compensation Arrangement by Share-Based Payment Award, Additional General Disclosures [Abstract] Entity Tax Identification Number Entity Tax Identification Number Number of shares of common stock authorized to be purchased (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized Shares issued, price per share, premium (in usd per share) Shares Issued Price Per Share Premium information on the premium over the closing price. Advertising expense Advertising Expense Significant Accounting Policies and Concentration of Risk [Line Items] Significant Accounting Policies and Concentrations of Risk [Line Items] Significant Accounting Policies and Concentrations of Risk Summary of Revenues Disaggregation of Revenue [Table Text Block] Revenue from Contract with Customer [Abstract] Term Loan A Drawn Term Loan A Drawn [Member] Represents term loan A drawn. Decrease in cash, cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Proceeds from (repayments of) accounts receivable securitization Proceeds from (Repayments of) Accounts Receivable Securitization Term Loans A, B and C Drawn Term Loans A, B and C Drawn [Member] Represents term loans A, B and C drawn. Debt Covenant Terms [Axis] Debt Covenant Terms [Axis] Debt Covenant Terms Entity Central Index Key Entity Central Index Key Maturing after one year through two years Maturing After One Year Through Two Years Amount of investment in debt securities maturing after one year through two years. Research and Development Expenses Research and Development Expense, Policy [Policy Text Block] Accrued Expenses Accrued Expenses [Policy Text Block] Represents accrued expenses policy. Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Collaborative and Other Relationships Collaborative Arrangement Disclosure [Text Block] Entity [Domain] Entity [Domain] Accounting Standards Update [Domain] Accounting Standards Update [Domain] City Area Code City Area Code Vest 25% Each Year Until Fully Vested Vest 25% Each Year Until Fully Vested [Member] Represents vest 25% each year until fully vested. Assets Assets [Abstract] Long-Term Debt, Type [Domain] Long-Term Debt, Type [Domain] Selling, General and Administrative Expenses Selling, General and Administrative Expenses, Policy [Policy Text Block] Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Sale of Stock [Axis] Sale of Stock [Axis] Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Net Loss Per Share Earnings Per Share, Policy [Policy Text Block] Annual Net Sales Under $1.5 Million Annual Net Sales Under $1.5 Billion [Member] Represents annual net sales under $1.5 billions. Stock-based compensation expense Share-Based Payment Arrangement, Noncash Expense Weighted average grant date fair value stock option awards (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Variable Rate [Axis] Variable Rate [Axis] Prior to the Second Anniversary Prior to the Second Anniversary [Member] Represents prior to the second anniversary. Disaggregation of Revenue [Line Items] Disaggregation of Revenue [Line Items] Percentage of common stock shares, beginning Percentage of Common Stock Shares Beginning Represents percentage of common stock shares beginning. Credit Agreement Credit Agreement [Member] Represents the credit agreement. Between the Second and Third Anniversaries Between the Second and Third Anniversaries [Member] Represents between the second and third anniversaries.