Total cash proceeds Proceeds from Divestiture of Businesses Term B And C Loan Term B And C Loan [Member] Term B And C Loan Conversion ratio Business Combination, Common Stock, Conversion Ratio Business Combination, Common Stock, Conversion Ratio Investments Investment, Policy [Policy Text Block] Schedule of Investments By Type Debt Securities, Available-for-Sale [Table Text Block] Award Timing Predetermined Award Timing Predetermined [Flag] Entity File Number Entity File Number Additional Paid-In Capital Additional Paid-in Capital [Member] Tabular List, Table Tabular List [Table Text Block] Shares reserved for future issuance under the Stock Incentive Plan Incentive Plan Incentive Plan [Member] Incentive Plan Recently Adopted Accounting Pronouncements and New Accounting Pronouncements Not Yet Adopted New Accounting Pronouncements, Policy [Policy Text Block] Finance lease liabilities: Finance Lease, Liability [Abstract] Proceeds from sale of BioCryst Ireland, net of cash divested Proceeds from Divestiture of Businesses, Net of Cash Divested Collaborative and other revenues Collaborative And Other Research And Development [Member] Collaborative And Other Research And Development Research and development tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount License revenue License and other revenues License [Member] Adjustment to Compensation: Adjustment to Compensation [Axis] Named Executive Officers, Footnote Named Executive Officers, Footnote [Text Block] Revenue Revenue from Contract with Customer [Text Block] Stock-based compensation Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost Employee stock purchase plan sales (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Shares reserved for future issuance under the Employee Stock Purchase Plan ESPP Employee Stock Purchase Plan [Member] Employee Stock Purchase Plan Total current expense provision Current Income Tax Expense (Benefit) Accounts Payable and Accrued Liabilities [Abstract] Adjustment to Compensation, Amount Adjustment to Compensation Amount Revenue, percentage Concentration Risk, Percentage Debt instrument, unamortized discount (premium) and debt issuance costs, net, total Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Stock-based compensation expense Stock-based compensation Share-Based Payment Arrangement, Noncash Expense Shares reserved for exercises of outstanding stock options Share-based Payment Arrangement, Option Outstanding stock options Share-Based Payment Arrangement, Option [Member] Sale of European ORLADEYO business Effective Income Tax Rate Reconciliation, Nondeductible Expense, Disposal of Business, Amount Effective Income Tax Rate Reconciliation, Nondeductible Expense, Disposal of Business, Amount Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] BioCryst Ireland BioCryst Ireland [Member] BioCryst Ireland Cash and Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Income Tax Disclosure [Line Items] Income Tax Disclosure [Line Items] Income Tax Disclosure Percent Effective Income Tax Rate Reconciliation, Percent [Abstract] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Total stockholders’ deficit Beginning balance Ending balance Equity, Attributable to Parent Other comprehensive income (loss): Other Comprehensive Income (Loss), Net of Tax [Abstract] Insider Trading Policies and Procedures [Line Items] Schedule of Property and Equipment Property, Plant and Equipment [Table Text Block] Common stock, shares authorized (in shares) Common Stock, Shares Authorized Annual Net Sales Range [Domain] Annual Net Sales Range [Domain] Annual Net Sales Range [Domain] Liabilities and Stockholders’ Deficit Liabilities and Equity [Abstract] State State and Local Jurisdiction [Member] Cover [Abstract] Money market funds Cash and Cash Equivalents, Fair Value Disclosure Divestiture of BioCryst Ireland Limited Disposal Groups, Including Discontinued Operations, Disclosure [Text Block] Maximum Maximum [Member] Exercisable (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price Remeasurement of share-based liability Adjustments to Additional Paid-in Capital, Remeasurement of Share-Based Liability Adjustments to Additional Paid-in Capital, Remeasurement of Share-Based Liability Estimated fair market value Debt Securities, Available-for-Sale, Unrealized Loss Position Factor D Program Factor D Program [Member] Factor D Program Non-PEO NEO Average Total Compensation Amount Non-PEO NEO Average Total Compensation Amount Debt Instrument [Line Items] Debt Instrument [Line Items] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Schedule of Restricted Stock Unit Activity Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block] Research and development costs Accrued Research And Development Costs Accrued Research And Development Costs Adjustment to Non-PEO NEO Compensation Footnote Adjustment to Non-PEO NEO Compensation Footnote [Text Block] Accounts payable Disposal Group, Including Discontinued Operation, Accounts Payable, Current Retirement Benefits [Abstract] Forgone Recovery due to Disqualification of Tax Benefits, Amount Forgone Recovery due to Disqualification of Tax Benefits, Amount Non-Rule 10b5-1 Arrangement Terminated Non-Rule 10b5-1 Arrangement Terminated [Flag] Pharmakon Advisors, LP Pharmakon Advisors, LP [Member] Pharmakon Advisors, LP Non-current liabilities Disposal Group, Including Discontinued Operation, Liabilities, Noncurrent Income (loss) before income taxes Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Entity Shell Company Entity Shell Company Long-Term Debt Type [Table] Schedule of Long-Term Debt Instruments [Table] Proceeds from issuance of debt Proceeds from Issuance of Debt Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Capitalized stock-based compensation costs Share-Based Payment Arrangement, Amount Capitalized Schedule of Income Taxes Paid, Net of Refunds Received Schedule of Cash Flow, Supplemental Disclosures [Table Text Block] Award Timing MNPI Considered Award Timing MNPI Considered [Flag] Term Loan Tranche C Term Loan Tranche C [Member] Term Loan Tranche C Beginning balance Ending balance Restructuring Reserve Domestic Income (Loss) from Continuing Operations before Income Taxes, Domestic Schedule of Stock-Based Compensation Expense Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Operating lease liabilities Current operating lease liabilities Operating Lease, Liability, Current Nontaxable or nondeductible items Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract] Interest on lease liabilities Finance Lease, Interest Expense Document Fiscal Period Focus Document Fiscal Period Focus Trade Receivables Receivable [Policy Text Block] Award Timing Method Award Timing Method [Text Block] Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost, Excluding Accrued Interest, after Allowance for Credit Loss Furniture and fixtures Furniture and Fixtures [Member] Award Type [Axis] Award Type [Axis] Royalty purchase agreement, royalties, percentage of annual net sales, based on reduction in sales Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales Based On Reduction In Sales Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales Based On Reduction In Sales Fair Value Measurements and Investments Investments and Other Noncurrent Assets [Text Block] Stock-Based Compensation Share-Based Payment Arrangement [Policy Text Block] Royalty release fee Disposal Group, Including Discontinued Operation, Consideration, Royalty Release Fee Disposal Group, Including Discontinued Operation, Consideration, Royalty Release Fee Trading Symbol Trading Symbol 2029 Lessee, Operating Lease, Liability, to be Paid, Year Four Changes in valuation allowances Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent Accrued interest paid Interest Expense, Long-Term Debt Entity Address, City or Town Entity Address, City or Town Finance leases Finance Lease, Weighted Average Discount Rate, Percent Marketable Securities [Line Items] Marketable Securities [Line Items] Effect of exchange rates on cash, cash equivalents and restricted cash Effect of Exchange Rate on Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation Non-PEO NEO Average Compensation Actually Paid Amount Non-PEO NEO Average Compensation Actually Paid Amount Statement of Income Location, Balance [Domain] Statement of Income Location, Balance [Domain] Shares reserved for vesting of restricted stock units Restricted Stock Units (RSUs) Unvested restricted stock unit awards Restricted Stock Units (RSUs) [Member] Compensation Actually Paid vs. Other Measure Compensation Actually Paid vs. Other Measure [Text Block] Royalty payment, number of tiers License Agreement, Royalty Payment, Number of Tiers License Agreement, Royalty Payment, Number of Tiers Entity Emerging Growth Company Entity Emerging Growth Company Finance leases Finance Lease, Weighted Average Remaining Lease Term Outstanding, beginning balance (in shares) Outstanding, ending balance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Repayments of lines of credit Repayments of Lines of Credit Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member] Total revenues Revenues Revenue from Contract with Customer, Including Assessed Tax Debt issuance costs, net, total Debt Issuance Costs, Net Restructuring Reserve [Roll Forward] Restructuring Reserve [Roll Forward] Less imputed interest Finance Lease, Liability, Undiscounted Excess Amount The Company Description Of Company [Policy Text Block] Description Of Company Common stock, shares, outstanding (in shares) Beginning balance (in shares) Ending balance (in shares) Common Stock, Shares, Outstanding Gain on sale of non-financial asset Gain (Loss) on Disposition of Other Assets Royalty Financing Obligations Royalty Financing Liabilities [Text Block] Royalty Financing Liabilities Schedule of Revenues Disaggregation of Revenue [Table Text Block] Current expense (benefit) provision: Current Income Tax Expense (Benefit), Continuing Operations [Abstract] Increase (decrease) in valuation allowance Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount Revenue-related reserves for discounts and allowances Revenue-Related Reserves For Discounts And Allowances Revenue-Related Reserves For Discounts And Allowances Exercise of stock options, net Stock Issued During Period, Value, Stock Options Exercised Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member] Neopharmed Neopharmed [Member] Neopharmed Outside of U.S. Geographic Distribution, Foreign [Member] Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Shares (in thousands) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Effective interest rate Debt Instrument, Interest Rate, Effective Percentage Entity Address, Postal Zip Code Entity Address, Postal Zip Code Restatement Determination Date Restatement Determination Date Income tax expense Total expense provision Income Tax Expense (Benefit) Total finance lease expense Financing Lease, Expense Financing Lease, Expense Debt instrument, basis spread on variable rate Debt Instrument, Basis Spread on Variable Rate Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued Pension Adjustments Service Cost Pension Adjustments Service Cost [Member] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Total property and equipment Property, Plant and Equipment, Gross Audit Information [Abstract] Audit Information Discontinued Operations and Disposal Groups [Abstract] Matching contributions Defined Contribution Plan, Employer Discretionary Contribution Amount Workforce Reduction Restructuring and Related Activities Disclosure [Text Block] Other income (expense): Other Income and Expenses [Abstract] Compensation Actually Paid vs. Company Selected Measure Compensation Actually Paid vs. Company Selected Measure [Text Block] Proceeds from collaborators Proceeds from Collaborators Federal Income Tax Paid, Federal, after Refund Received All Trading Arrangements All Trading Arrangements [Member] Equity Awards Adjustments, Footnote Equity Awards Adjustments, Footnote [Text Block] Total Shareholder Return Vs Peer Group Total Shareholder Return Vs Peer Group [Text Block] Vested and expected to vest (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Unamortized deferred financing costs Unamortized Deferred Financing Costs Unamortized Deferred Financing Costs Accrued expenses Total accrued expenses Accrued Liabilities, Current Maximum number of products, doses Maximum Number Of Products Permitted To Be Obtained, Doses Maximum Number Of Products Permitted To Be Obtained, Doses Net federal and state operating losses Deferred Tax Assets, Operating Loss Carryforwards, Domestic Incremental fair value Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Modification, Incremental Fair Value Share-Based Compensation Arrangement By Share-Based Payment Award, Options, Modification, Incremental Fair Value Other Effective Income Tax Rate Reconciliation, Other Adjustments, Amount Unvested, beginning balance (in shares) Unvested, ending balance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Commitments and Contingencies Disclosure [Abstract] Net cash provided by (used in) operating activities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation Long-term investments Long-Term Investments Debt instrument, term (in months) Debt Instrument, Term Effective Income Tax Rate Reconciliation [Table] Effective Income Tax Rate Reconciliation [Table] Property, plant and equipment, useful life (in years) Property, Plant and Equipment, Useful Life Preferred stock, par or stated value (in usd per share) Preferred Stock, Par or Stated Value Per Share Schedule of Stock Option Awards Granted Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Equity Valuation Assumption Difference, Footnote Equity Valuation Assumption Difference, Footnote [Text Block] PEO Total Compensation Amount PEO Total Compensation Amount Long-term Debt, Type [Axis] Long-Term Debt, Type [Axis] Vested and expected to vest (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Money market funds Money Market Funds [Member] 2029 Finance Lease, Liability, to be Paid, Year Four Numerator: Net Income (Loss) Available to Common Stockholders, Diluted [Abstract] Torii Pharmaceutical Co Torii Pharmaceutical Co [Member] Torii Pharmaceutical Co Equity Components [Axis] Equity Components [Axis] Property, Plant and Equipment [Line Items] Property, Plant and Equipment [Line Items] Vesting of restricted stock units Stock Issued During Period, Value, Restricted Stock Award, Gross Non-Rule 10b5-1 Arrangement Adopted Non-Rule 10b5-1 Arrangement Adopted [Flag] Trade Accounts Receivable Trade Accounts Receivable [Member] Product sales, net Product [Member] Number of reportable segments Number of Reportable Segments HHS Office of the Administration for Strategic Preparedness and Response HHS Office of the Administration for Strategic Preparedness and Response [Member] HHS Office of the Administration for Strategic Preparedness and Response Percentage of common stock shares, ending Percentage Of Common Stock Shares Ending Percentage Of Common Stock Shares Ending Interest income Interest and Other Income Entity Address, State or Province Entity Address, State or Province Principal payments on finance lease liabilities Finance Lease, Principal Payments Antidilutive Security, Excluded EPS Calculation [Table] Antidilutive Security, Excluded EPS Calculation [Table] Non-current assets Disposal Group, Including Discontinued Operation, Assets, Noncurrent Aggregate principal amount not exceeding Debt Instrument, Unused Borrowing Capacity, Amount Total current liabilities Liabilities, Current Vesting of restricted stock units (in shares) Stock Issued During Period, Shares, Restricted Stock Award, Gross Individual: Individual [Axis] Royalties Monetiztions [Table] Royalties Monetiztions [Table] Royalties Monetiztions Income Tax Jurisdiction [Domain] Income Tax Jurisdiction [Domain] Finance lease assets obtained in exchange for finance lease liabilities Right-of-Use Asset Obtained in Exchange for Finance Lease Liability Document Annual Report Document Annual Report Research and development Research and Development Expense [Member] Non-employee Directors Non Employee Directors [Member] Non Employee Directors Thirty-six Equal Monthly Installments Thirty six Equal Monthly Installments [Member] Thirty six Equal Monthly Installments 2021 RPI Royalty Agreement 2021 RPI Royalty Agreement [Member] 2021 RPI Royalty Agreement Forgone Recovery, Explanation of Impracticability Forgone Recovery, Explanation of Impracticability [Text Block] Repayment of principal on term loans Repayments of Long-Term Debt Capitalized R&D Deferred Tax Asset, In-Process Research and Development Entity Interactive Data Current Entity Interactive Data Current Exercisable at December 31, 2025 Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value Share-based payment awards Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount Schedule of Stock-Based Compensation Expense and Stock Option Activity Disclosure of Share-Based Compensation Arrangements by Share-Based Payment Award [Table Text Block] Less: Segment Reconciliation [Abstract] Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] Long-Lived Tangible Asset [Axis] Long-Lived Tangible Asset [Axis] 2027 Finance Lease, Liability, to be Paid, Year Two Royalty income Deferred Tax Assets Royalty Income Deferred Tax Assets Royalty Income Accumulated amortization Finance Lease, Right-of-Use Asset, Accumulated Amortization Other assets Other Assets, Noncurrent Entity Central Index Key Entity Central Index Key PEO Name PEO Name Net assets sold Disposal Group, Including Discontinued Operation, Net Assets Sold Disposal Group, Including Discontinued Operation, Net Assets Sold Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member] Outstanding Aggregate Erroneous Compensation Amount Outstanding Aggregate Erroneous Compensation Amount Schedule of Basic and Diluted Net Income (Loss) Per Share Schedule of Earnings Per Share, Basic, by Common Class, Including Two Class Method [Table Text Block] Schedule of Segment Reporting Information, by Segment [Table] Schedule of Segment Reporting Information, by Segment [Table] Nontaxable or nondeductible items Effective Income Tax Rate Reconciliation, Nondeductible Expense, Amount [Abstract] (Increase) decrease in prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Exercise Price Award Exercise Price Entity Filer Category Entity Filer Category Income tax expense (benefit) at federal statutory rate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Upfront consideration to be received Disposal Group, Including Discontinued Operation, Consideration Secured term loan Long-Term Debt, Excluding Current Maturities Long-term inventory, net Inventory, Noncurrent Vesting [Domain] Vesting [Domain] Cash and cash equivalents Disposal Group, Including Discontinued Operation, Cash and Cash Equivalents Realized gains or losses reclassified out of accumulated other comprehensive income Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member] Decrease in royalty financing obligations Reduction to royalty financing obligation Increase (Decrease) In Royalty Financing Liabilities Increase (Decrease) In Royalty Financing Liabilities Entity Address, Address Line One Entity Address, Address Line One Research and development Research and development (excluding stock-based compensation) Research and Development Expense Accumulated Other Comprehensive Income AOCI Attributable to Parent [Member] Retirement Policy Retirement Policy [Policy Text Block] Retirement Policy Shares withheld for taxes for vesting of restricted stock units (in shares) Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation Payment of royalty release fees Payment Of Royalty Release Fees Payment Of Royalty Release Fees Foreign currency losses, net Gain (Loss) on Foreign Currency Derivative Instruments Not Designated as Hedging Instruments Work-in-process Inventory, Work in Process, Gross Equity modification associated with sale of BioCryst Ireland Equity Modification Associated With Sale Of Business Equity Modification Associated With Sale Of Business Schedule of Shares Reserved for Future Issuance of Common Stock Schedule of Stock by Class [Table Text Block] Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] Shares reserved for future issuance under the Inducement Equity Incentive Plan Inducement Plan Inducement Plan [Member] Inducement Plan Fair Value as of Grant Date Award Grant Date Fair Value Operating loss carryforwards, total Operating Loss Carryforwards Changes in unrecognized tax benefits Effective Income Tax Rate Reconciliation, Tax Contingency, Amount Stock options to purchase common stock (in shares) Incremental Common Shares Attributable to Dilutive Effect of Share-Based Payment Arrangements Granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Title and Position [Domain] Title and Position [Domain] Total operating expenses Costs and Expenses Forfeited (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Total unrecognized compensation cost Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount Accumulated amortization Operating Lease Right-of-use Asset Accumulated Amortization Operating Lease Right-of-use Asset Accumulated Amortization Changed Peer Group, Footnote Changed Peer Group, Footnote [Text Block] Counterparty Name [Domain] Counterparty Name [Domain] Stock issued during period (in shares) Stock Issued During Period, Shares, Warrants Exercised Stock Issued During Period, Shares, Warrants Exercised 2027 Lessee, Operating Lease, Liability, to be Paid, Year Two Investments, All Other Investments [Abstract] Adjustment To PEO Compensation, Footnote Adjustment To PEO Compensation, Footnote [Text Block] Outstanding (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Germany GERMANY Gain on award modification Gain (Loss) on Remeasurement of Share-Based Liability Gain (Loss) on Remeasurement of Share-Based Liability Title Trading Arrangement, Individual Title Peer Group Total Shareholder Return Amount Peer Group Total Shareholder Return Amount Cash paid for interest on royalty financing obligations Interest Paid, Royalty Financing Liabilities Interest Paid, Royalty Financing Liabilities Other current liabilities Disposal Group, Including Discontinued Operation, Other Liabilities, Current Cash consideration Payments to Acquire Businesses, Gross Non-PEO NEO Non-PEO NEO [Member] Outstanding at December 31, 2025 Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value Employee stock purchase plan sales Stock Issued During Period, Value, Employee Stock Purchase Plan Gross Unrealized Gains Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax Award Type [Domain] Award Type [Domain] Prepayment premium and fees on term loans Prepayment outstanding principal Payment for Debt Extinguishment or Debt Prepayment Cost 2026 Lessee, Operating Lease, Liability, to be Paid, Year One Equity Awards Adjustments Equity Awards Adjustments [Member] Leasehold improvements Leasehold Improvements [Member] Advertising costs Advertising Expense Pension Benefits Adjustments, Footnote Pension Benefits Adjustments, Footnote [Text Block] Disaggregation of Revenue [Line Items] Disaggregation of Revenue [Line Items] Other income Other income Other Income Compensation Amount Outstanding Recovery Compensation Amount Deferred expense (benefit) provision: Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract] Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Expected dividend yield Expected Dividend Yield Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate Schedule of Operating Lease Assets and Liabilities Lessee, Operating Lease, Assets and Liabilities [Table Text Block] Tabular disclosure of the assets and liabilities of the lessee's operating lease. Term A Loan Term A Loan [Member] Term A Loan Recovery of Erroneously Awarded Compensation Disclosure [Line Items] Variable rate floor Debt Instrument, Variable Rate Floor Debt Instrument, Variable Rate Floor MNPI Disclosure Timed for Compensation Value MNPI Disclosure Timed for Compensation Value [Flag] Term C Loan Term C Loan [Member] Term C Loan Statutory tax rate difference between Ireland and the United States Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent Maturity period of short term investment (in months) Maturity Period Of Short Term Investment Maturity Period Of Short Term Investment Denominator: Weighted Average Number of Shares Outstanding Reconciliation [Abstract] Revenues: Revenues [Abstract] Documents Incorporated by Reference Documents Incorporated by Reference [Text Block] Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Finance Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Amount [Abstract] Avoralstat Avoralstat [Member] Avoralstat Accumulated other comprehensive income Accumulated Other Comprehensive Income (Loss), Net of Tax Sales and marketing (excluding stock-based compensation) Selling and Marketing Expense Financial Instruments [Domain] Financial Instruments [Domain] Unrealized (loss) gain on available for sale investments OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax Total deferred tax liabilities Deferred Tax Liabilities, Gross OMERS Royalty Agreement OMERS Royalty Agreement [Member] OMERS Royalty Agreement Accrued Expenses Accrued Expenses Policy [Policy Text Block] Accrued Expenses Policy Aggregate Pension Adjustments Service Cost Aggregate Pension Adjustments Service Cost [Member] Significant Customers and Other Risks Concentration Of Market Risk Policy [Policy Text Block] Concentration Of Market Risk Policy Other Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount Inventory, net Inventory, Net Minimum Minimum [Member] Contingent consideration to be received Disposal Group, Including Discontinued Operation, Contingent Consideration Disposal Group, Including Discontinued Operation, Contingent Consideration Accounts, Notes, Loans and Financing Receivable [Line Items] Accounts, Notes, Loans and Financing Receivable [Line Items] Company Selected Measure Name Company Selected Measure Name Cost of Product Sales Cost of Goods and Service [Policy Text Block] Non-cash interest expense on secured term loan and amortization of debt issuance costs Non-Cash Interest Expense On Royalty Financing Liabilities And Secured Term Loan And Amortization Of Debt Issuance Costs Non-Cash Interest Expense On Royalty Financing Liabilities And Secured Term Loan And Amortization Of Debt Issuance Costs Debt Debt Disclosure [Text Block] Aggregate Available Trading Arrangement, Securities Aggregate Available Amount Accounts payable Accounts Payable, Current Share-based liability Share-based Liability Share-based Liability Operating cash flows for operating leases Operating Lease, Payments Stock Appreciation Rights (SARs) Stock Appreciation Rights (SARs) [Member] Foreign Current Foreign Tax Expense (Benefit) Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Weighted average shares of common stock outstanding: diluted (in shares) Weighted Average Number of Shares Outstanding, Diluted Options, vested in period, fair value Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value Restricted cash in other assets Restricted Cash and Cash Equivalents, Included In Other Assets, Non-Current Restricted Cash and Cash Equivalents, Included In Other Assets, Non-Current Non-GAAP Measure Description Non-GAAP Measure Description [Text Block] Entity Small Business Entity Small Business Royalty purchase agreement, royalties, percentage of sublicense revenue in other markets Royalty Purchase Agreement Royalties Percentage Of Sublicense Revenue In Other Markets Royalty Purchase Agreement Royalties Percentage Of Sublicense Revenue In Other Markets Income Tax Disclosure [Abstract] Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding State Current State and Local Tax Expense (Benefit) Document Transition Report Document Transition Report Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] Percent of interest payment Percent of Interest Payment Percent of Interest Payment Total lease payments Finance Lease, Liability, to be Paid Underlying Securities Award Underlying Securities Amount Equity Component [Domain] Equity Component [Domain] Total ORLADEYO ORLADEYO ORLADEYO [Member] ORLADEYO Document Period End Date Document Period End Date Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] Income Taxes Income Tax Disclosure [Text Block] Royalties payable Royalties Payable, Current Royalties Payable, Current Geographic Distribution [Domain] Geographic Distribution [Domain] United Kingdom UNITED KINGDOM Operating lease assets: Operating Lease Assets [Abstract] Operating Lease Assets Awards Close in Time to MNPI Disclosures, Table Awards Close in Time to MNPI Disclosures [Table Text Block] Incentive Plan and Inducement Plan Incentive Plan and Inducement Plan [Member] Incentive Plan and Inducement Plan Exercisable (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Annual Net Sales Of $2 Million Annual Net Sales Of $2 Million [Member] Annual Net Sales Of $2 Million Document Type Document Type Significant Unobservable Inputs (Level 3) Fair Value, Inputs, Level 3 [Member] Net Income (Loss) Per Share Earnings Per Share [Text Block] Name Outstanding Recovery, Individual Name Marketable Securities [Table] Marketable Securities [Table] Additional paid-in capital Additional Paid in Capital Office equipment Office Equipment [Member] Product and Service [Axis] Product and Service [Axis] Vested and expected to vest (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Total current assets Assets, Current Statistical Measurement [Axis] Statistical Measurement [Axis] Cancelled or Forfeited (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price Aggregate Erroneous Compensation Amount Aggregate Erroneous Compensation Amount Disposal Group Name [Axis] Disposal Group Name [Axis] Exercised Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value Withholding taxes paid on stock-based awards Payment, Tax Withholding, Share-Based Payment Arrangement Peer Group Issuers, Footnote Peer Group Issuers, Footnote [Text Block] Total other comprehensive (loss) income Other comprehensive income (loss) Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Current liabilities: Liabilities, Current [Abstract] Research and development credits Deferred Tax Assets, Tax Credit Carryforwards, Research Weighted Average Remaining Contractual Term (in years) and Aggregate Intrinsic Value Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract] License and other revenues License and Other Revenues [Member] License and Other Revenues Sale of European ORLADEYO business Effective Income Tax Rate Reconciliation, Nondeductible Expense, Disposal of Business, Percentage Effective Income Tax Rate Reconciliation, Nondeductible Expense, Disposal of Business, Percentage Price per share (in usd per share) Business Combination, Price Per Share Quoted Price in Active Markets (Level 1) Fair Value, Inputs, Level 1 [Member] Net income (loss) per common share: diluted (in usd per share) Net income (loss) per common share, diluted (in usd per share) Earnings Per Share, Diluted Trade receivables Accounts Receivable, after Allowance for Credit Loss, Current Revenue Recognition [Abstract] Future Royalties Payable Future Royalties Payable [Member] Future Royalties Payable State Income Tax Paid, State and Local, after Refund Received Auditor Location Auditor Location Number of separate prepayments Debt Instrument, Number Of Separate Prepayments Debt Instrument, Number Of Separate Prepayments Accumulated Other Comprehensive Income Comprehensive Income, Policy [Policy Text Block] Domestic Tax Jurisdiction Domestic Tax Jurisdiction [Member] Non-cash increase to operating lease assets due to remeasurement of operating lease liabilities Non-cash Increase In Operating Lease Assets Due To Remeasurement Of Operating Lease Liabilities Non-cash Increase In Operating Lease Assets Due To Remeasurement Of Operating Lease Liabilities Accrued Expenses Accounts Payable and Accrued Liabilities Disclosure [Text Block] Less imputed interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Tax Credit Carryforward [Axis] Tax Credit Carryforward [Axis] Other Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent Total income taxes paid, net of refunds received Income Taxes Paid, Net Restricted Cash and Cash Equivalents [Axis] Restricted Cash and Cash Equivalents [Axis] OMERS Capital Markets OMERS Capital Markets [Member] OMERS Capital Markets Granted (in usd per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Number of plans Share-Based Payment Arrangement, Number of Plans Share-Based Payment Arrangement, Number of Plans Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Compensation and benefits Employee-related Liabilities, Current Property and Equipment Property, Plant and Equipment Disclosure [Text Block] Total lease payments Lessee, Operating Lease, Liability, to be Paid Number of product delivered, doses Number Of Product Delivered, Doses Number Of Product Delivered, Doses Average maturity period of high quality marketable securities (in months) Average Maturity Period Of High Quality Marketable Securities Average Maturity Period Of High Quality Marketable Securities Schedule of Other Supplemental Information Related to Leases Other Supplemental Information Related to Leases [Table Text Block] Other Supplemental Information Related to Leases Shares issued, common stock, premium Shares Issued Common Stock Premium Shares Issued Common Stock Premium Annual Net Sales Over $230,000 Annual Net Sales Over $230,000 [Member] Annual Net Sales Over $230,000 Expiration Date Trading Arrangement Expiration Date Debt instrument, prepayment fee, percentage of principal voluntary payments Debt Instrument Prepayment Fee Percentage Of Principal Voluntary Payments Debt Instrument Prepayment Fee Percentage Of Principal Voluntary Payments Property and equipment, net Property and equipment, net Property, Plant and Equipment, Net Compensation Actually Paid vs. Net Income Compensation Actually Paid vs. Net Income [Text Block] Inventory Inventory, Policy [Policy Text Block] Restructuring Cost [Table] Restructuring Cost [Table] Entity Current Reporting Status Entity Current Reporting Status Receivables [Abstract] Awards Close in Time to MNPI Disclosures Awards Close in Time to MNPI Disclosures [Table] Contract termination Loss on Contract Termination Income tax expense (benefit) at federal statutory rate Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount Financial Instrument [Axis] Financial Instrument [Axis] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Executive Category: Executive Category [Axis] Share-based payment awards Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent Royalty purchase agreement, royalties, percentage of annual net sales in key territories Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales In Key Territories Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales In Key Territories State and local income taxes, net of federal income tax effect Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent Finance lease liabilities Current finance lease liabilities Finance Lease, Liability, Current Reserves Inventory Valuation Reserves Net proceeds from term loans Proceeds from Issuance of Long-Term Debt Current Fiscal Year End Date Current Fiscal Year End Date Ireland IRELAND Expected Term in Years Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Weighted Average Grant Date Fair Value Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Number of shares available for grant (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Total inventory, net Inventory, Including Noncurrent Portion Inventory, Including Noncurrent Portion Collaborative and Other Relationships Collaborative Arrangement Disclosure [Text Block] Weighted average grant date fair value per share (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Equity Awards Adjustments, Excluding Value Reported in Compensation Table Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member] Annual Net Sales Greater Than $1.5 Million Annual Net Sales Greater Than $1.5 Million [Member] Annual Net Sales Greater Than $1.5 Million Receivables Receivables, Net, Current Schedule of Assets Measured at Fair Value on Recurring Basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Beginning balance Ending balance Unrecognized Tax Benefits Total (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Potential milestone payments payable Potential Milestone Payments Payable Potential Milestone Payments Payable Debt Covenant Terms [Domain] Debt Covenant Terms [Domain] Debt Covenant Terms Lease Obligations Lessee, Operating Leases [Text Block] Net cash (used in) provided by financing activities Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Percentage of salary to purchase common stock, maximum Percentage Of Salary To Purchase Common Stock Maximum Percentage Of Salary To Purchase Common Stock Maximum Measure: Measure [Axis] Long-Lived Tangible Asset [Domain] Long-Lived Tangible Asset [Domain] Cost of product sales Cost of Product and Service Sold Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Statement of Financial Position [Extensible Enumeration] Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss, Statement of Financial Position [Extensible Enumeration] Disposal Group Classification [Domain] Disposal Group Classification [Domain] Prepaid expenses and other current assets Disposal Group, Including Discontinued Operation, Prepaid and Other Assets, Current Pay vs Performance Disclosure, Table Pay vs Performance [Table Text Block] Forgone Recovery due to Violation of Home Country Law, Amount Forgone Recovery due to Violation of Home Country Law, Amount Risk-Free Interest Rate Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Amortization of debt issuance costs Amortization of Debt Issuance Costs Entity Tax Identification Number Entity Tax Identification Number Significant Accounting Policies and Concentrations of Risk [Line Items] Significant Accounting Policies and Concentrations of Risk [Line Items] Significant Accounting Policies and Concentrations of Risk Retirement Policy Retirement Policy [Member] Retirement Policy Loan Agreement Loan Agreement [Member] Loan Agreement Outstanding, beginning balance (in usd per share) Outstanding, ending balance (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Common stock, shares, issued (in shares) Common Stock, Shares, Issued Operating leases Operating Lease, Weighted Average Remaining Lease Term Debt Covenant Terms [Axis] Debt Covenant Terms [Axis] Debt Covenant Terms Effect of dilutive securities: Dilutive Securities, Effect on Basic Earnings Per Share [Abstract] Royalty financing obligations Royalty Financing Liabilities, Current Royalty Financing Liabilities, Current Entity Public Float Entity Public Float Royalty revenues paid and payable Royalty Revenues Paid And Payable Represents royalties revenues payable. Interest expense Interest expense Interest Expense, Nonoperating Trading Arrangement: Trading Arrangement [Axis] Total Shareholder Return Amount Total Shareholder Return Amount Security Exchange Name Security Exchange Name Foreign Income Tax Paid, Foreign, after Refund Received Capitalized software costs included in accrued expenses Capital Expenditures Incurred but Not yet Paid Expiration of research and development tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Expiration Of Research And Development Tax Credits, Amount Effective Income Tax Rate Reconciliation, Tax Credit, Expiration Of Research And Development Tax Credits, Amount Statement [Line Items] Statement [Line Items] Rule 10b5-1 Arrangement Adopted Rule 10b5-1 Arrangement Adopted [Flag] Percentage of common stock shares, beginning Percentage Of Common Stock Shares Beginning Percentage Of Common Stock Shares Beginning Cash and cash equivalents Cash and Cash Equivalent Inventory, net Disposal Group, Including Discontinued Operation, Inventory, Current Subsequent Event [Line Items] Subsequent Event [Line Items] Research Tax Credit Carryforward Research Tax Credit Carryforward [Member] Credit Agreement Credit Agreement [Member] Credit Agreement Income Tax Disclosure [Table] Income Tax Disclosure [Table] Income Tax Disclosure Common Stock Common Stock [Member] Vested (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Weighted average discount rate: Finance Leases Finance Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract] Subsidiary, Sale of Stock [Line Items] Subsidiary, Sale of Stock [Line Items] Decrease in cash, cash equivalents and restricted cash Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation Dilutive potential common shares (in shares) Weighted Average Number of Shares Outstanding, Diluted, Adjustment Professional fees Accrued Professional Fees, Current Berotralstat Berotralstat [Member] Berotralstat Significant Accounting Policies and Concentrations of Risk Significant Accounting Policies [Text Block] Statistical Measurement [Domain] Statistical Measurement [Domain] Royalty Financing Obligations Royalty Financing Liabilities [Policy Text Block] Royalty Financing Liabilities Thereafter Lessee, Operating Lease, Liability, to be Paid, after Year Five Debt Debt, Policy [Policy Text Block] Leases [Abstract] Increase in accounts payable and accrued expenses Increase (Decrease) in Accounts Payable Schedule of Major Classes of Assets and Liabilities Sold Disposal Groups, Including Discontinued Operations [Table Text Block] Type of Restructuring [Domain] Type of Restructuring [Domain] Shares withheld for taxes for vesting of restricted stock units Share-Based Payment Arrangement, Decrease for Tax Withholding Obligation Gross Unrealized Losses Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Trading Arrangements, by Individual Trading Arrangements, by Individual [Table] Net income (loss) per common share: basic (in usd per share) Net income (loss) per common share, basic (in usd per share) Earnings Per Share, Basic Expiration of research and development tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Expiration Of Research And Development Tax Credits, Percent Effective Income Tax Rate Reconciliation, Tax Credit, Expiration Of Research And Development Tax Credits, Percent Total inventory Inventory, Gross Total shares reserved for future issuance (in shares) Common Stock, Capital Shares Reserved for Future Issuance Number of annual installments, vesting Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting, Number of Installments Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting, Number of Installments Changes in unrecognized tax benefits Effective Income Tax Rate Reconciliation, Tax Contingency, Percent Equity Disclosure [Table] Subsidiary or Equity Method Investee, Sale of Stock, Type [Table] Total deferred tax assets Deferred Tax Assets, Gross Schedule of Segment Reporting Information, by Segment Schedule of Segment Reporting Information, by Segment [Table Text Block] Inventory Disclosure [Abstract] Finance lease assets: Finance Lease Assets [Abstract] Finance Lease Assets Annual Net Sales Over $550,000 Annual Net Sales Over $550,000 [Member] Annual Net Sales Over $550,000 Compensation and related personnel costs Compensation And Related Personnel Costs [Member] Compensation And Related Personnel Costs 2028 Finance Lease, Liability, to be Paid, Year Three Award Timing MNPI Disclosure Award Timing MNPI Disclosure [Text Block] Research and Development Expenses Research and Development Expense, Policy [Policy Text Block] Athyrium Athyrium [Member] Athyrium Trade Receivables [Table] Accounts and Financing Receivables [Table] RAPIVAB RAPIVAB [Member] RAPIVAB Royalty purchase agreement, royalties, percentage of purchase price Royalty Purchase Agreement Royalties Percentage Of Purchase Price Royalty Purchase Agreement Royalties Percentage Of Purchase Price Beginning balance Ending balance Royalty Financing Liabilities Royalty Financing Liabilities Total stock-based compensation costs included in operating expenses Total stock-based compensation costs included in operating expenses Share-Based Payment Arrangement, Expense Current assets: Assets, Current [Abstract] Total liabilities and stockholders’ deficit Liabilities and Equity Foreign Currency Foreign Currency Transactions and Translations Policy [Policy Text Block] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Stock issued during period, shares, acquisitions (in shares) Stock Issued During Period, Shares, Acquisitions Shares (in thousands) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward] Concentration Risk Benchmark [Axis] Concentration Risk Benchmark [Axis] Other Deferred Tax Assets, Other Interest rate, increase Debt Instrument, Interest Rate, Increase (Decrease) Accounting Policies [Abstract] Accounting Policies [Abstract] Schedule of Maturities of Operating Lease Liabilities Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block] Concentration Risk Type [Domain] Concentration Risk Type [Domain] Pay vs Performance Disclosure [Line Items] Portion of interest that may be capitalized as principal Debt Instrument, Portion Of Interest That May Be Capitalized As Principal Debt Instrument, Portion Of Interest That May Be Capitalized As Principal Total operating lease liabilities Total Operating Lease, Liability Obligations of U.S. Government and its agencies US Government Agencies Debt Securities [Member] Foreign currency translation adjustment Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Issuance of shares to directors in lieu of cash retainer (in shares) Stock Issued During Period, Shares, Issued for Services Line of Credit Facility, Lender [Domain] Line of Credit Facility, Lender [Domain] Periodic payment, interest Debt Instrument, Periodic Payment, Interest Amortization of right-of-use assets Finance Lease, Right-of-Use Asset, Amortization Royalty purchase agreement, royalties, purchase price, amount Royalty Purchase Agreement Royalties Purchase Price Amount Royalty Purchase Agreement Royalties Purchase Price Amount PIK Interest Payment is Made Pik Interest Payment Is Made [Member] Pik Interest Payment Is Made Transaction-related costs Transaction-Related Costs, Current Transaction-Related Costs, Current Potential milestone payments payable if regulatory approval before milestone Potential Milestone Payments Payable If Regulatory Approval Before Milestone Potential Milestone Payments Payable If Regulatory Approval Before Milestone Annual global net sales License Agreement, Annual Global Net Sales License Agreement, Annual Global Net Sales Sale of stock, maximum offering (in shares) Sale Of Stock, Shares, Maximum Offering Sale Of Stock, Shares, Maximum Offering Significant Accounting Policies and Concentrations of Risk [Table] Significant Accounting Policies and Concentrations of Risk [Table] Significant Accounting Policies and Concentrations of Risk Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Company Selected Measure Amount Company Selected Measure Amount 2028 Lessee, Operating Lease, Liability, to be Paid, Year Three Net comprehensive income (loss) Comprehensive Income (Loss), Net of Tax, Attributable to Parent Disposal Group Name [Domain] Disposal Group Name [Domain] Name Measure Name Schedule of Income (Loss) Before Provision For Income Taxes Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] Maturing in one year or less Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One Unvested restricted stock unit awards (in shares) Incremental Common Shares Attributable to Dilutive Effect of Equity Unit Purchase Agreements Long-term debt, total Long-Term Debt Legal Entity [Axis] Legal Entity [Axis] Total assets Assets Laboratory equipment Laboratory Equipment [Member] Laboratory Equipment Vested (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Restricted Cash Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block] Principal payments on royalty financing obligations Repayment Of Royalty Financing Liabilities, Principal Repayment Of Royalty Financing Liabilities, Principal Income Taxes Income Tax, Policy [Policy Text Block] Cash flows from operating activities: Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] Receivable Type [Axis] Receivable Type [Axis] Research and development tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent BCX17725 BCX17725 [Member] BCX17725 Concentration Risk Type [Axis] Concentration Risk Type [Axis] Inventory Inventory Disclosure [Text Block] Annual Net Sales Between $150,000 and $230,000 Annual Net Sales Between $150,000 and $230,000 [Member] Annual Net Sales Between $150,000 and $230,000 Assets Assets, Fair Value Disclosure [Abstract] Collateral for Credit Collateral For Credit [Member] Collateral For Credit Restructuring costs Workforce reduction expense recorded during the year ended December 31, 2025 Restructuring Costs 2026 Finance Lease, Liability, to be Paid, Year One Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Operating lease assets obtained in exchange for operating lease liabilities Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Debt instrument, exit fee, percentage of principal Debt Instrument Exit Fee Percentage Of Principal Debt Instrument Exit Fee Percentage Of Principal Other revenues Other Income From Contract With Customer [Member] Other Income From Contract With Customer Significant Other Observable Inputs (Level 2) Fair Value, Inputs, Level 2 [Member] Exercise of warrants (in shares) Class Of Warrant Or Right Exercised During Period Class Of Warrant Or Right Exercised During Period Document Financial Statement Error Correction [Flag] Document Financial Statement Error Correction [Flag] State and local income taxes, net of federal income tax effect Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount Insider Trading Policies and Procedures Not Adopted Insider Trading Policies and Procedures Not Adopted [Text Block] Business Combination [Domain] Business Combination [Domain] Fees Debt Instrument, Fee Amount Gain on sale Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal Shares issuable under the employee stock purchase plan (in shares) Incremental Common Shares Attributable To Dilutive Effect Of Share Purchase Plans Incremental Common Shares Attributable To Dilutive Effect Of Share Purchase Plans Weighted average remaining lease term: Operating Leases Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract] Schedule of Components of Expense (Benefit) For Income Taxes Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Term B Loan Term B Loan [Member] Term B Loan Trade Receivables Trade Receivables [Text Block] Trade Receivables Plan Name [Axis] Plan Name [Axis] Property and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Right of use asset Deferred Tax Liabilities Right-Of-Use Assets Deferred Tax Liabilities Right-Of-Use Assets PEO PEO [Member] Employee Severance Employee Severance [Member] Changes in operating assets and liabilities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Changes in valuation allowances Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount Payment of Pharmakon PIK Interest Payments For Paid-In-Kind Interest Payments For Paid-In-Kind Interest Fixed assets Deferred Tax Liabilities, Property, Plant and Equipment Expected Volatility Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate Accumulated Deficit Retained Earnings [Member] Income Tax Jurisdiction [Axis] Income Tax Jurisdiction [Axis] Schedule of Accrued Liabilities Schedule of Accrued Liabilities [Table Text Block] Share-Based Payment Arrangement [Abstract] Beginning of year End of year Total cash, cash equivalents and restricted cash Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation Income Statement [Abstract] Income Statement [Abstract] Product and Service [Domain] Product and Service [Domain] Cash, cash equivalents, and investments Cash, Cash Equivalents, Short and Long-Term Investments Cash, Cash Equivalents, Short and Long-Term Investments Restatement does not require Recovery Restatement Does Not Require Recovery [Text Block] Organization, Consolidation and Presentation of Financial Statements [Abstract] Peramivir Peramivir [Member] Peramivir City Area Code City Area Code Award Timing, How MNPI Considered Award Timing, How MNPI Considered [Text Block] General and administrative (excluding stock-based compensation) General and Administrative Expense Cash flows from investing activities: Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract] Pay vs Performance Disclosure Pay vs Performance Disclosure [Table] Number of milestone payments License Agreement, Number of Milestone Payments License Agreement, Number of Milestone Payments Annual Net Sales Between $350,000 and $550,000 Annual Net Sales Between 350000 And 550000 [Member] Annual Net Sales Between 350000 And 550000 Disposal Group, Disposed of by Sale, Not Discontinued Operations Disposal Group, Disposed of by Sale, Not Discontinued Operations [Member] Effective Income Tax Rate Reconciliation [Line Items] Effective Income Tax Rate Reconciliation [Line Items] Selling, general and administrative Selling, General and Administrative Expenses [Member] Schedule of Lease Expense Under Operating and Finance Leases and Supplemental Cash Flow Information Lease, Cost [Table Text Block] Loss on impairment Tangible Asset Impairment Charges Taxes withheld on stock-based awards included in accrued expenses Withholding Taxes Accrued Withholding Taxes Accrued Capitalized interest rate Debt Instrument Capitalized Interest Rate Debt Instrument Capitalized Interest Rate U.S. Federal Deferred Federal Income Tax Expense (Benefit) Income Tax Disclosure [Roll Forward] Unrecognized Tax Benefits [Roll Forward] Auditor Name Auditor Name Issuance of shares to directors in lieu of cash retainer Stock Issued During Period, Value, Issued for Services Annual Net Sales Under $350,000 Annual Net Sales Under $350,000 [Member] Annual Net Sales Under $350,000 Supplemental cash flow disclosure: Supplemental Cash Flow Information [Abstract] Royalty purchase agreement, royalties, percentage of annual net sales Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales Restructuring Cost and Reserve [Line Items] Restructuring Cost and Reserve [Line Items] Other Performance Measure, Amount Other Performance Measure, Amount Weighted Average Exercise Price per Share Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Payment of debt issuance costs on Pharmakon Tranche A term loan Payments of Debt Issuance Costs Fair Value Measurements Fair Value Measurement, Policy [Policy Text Block] Right of use assets Right-Of-Use-Assets, Noncurrent Right-Of-Use-Assets, Noncurrent Amount Income Tax Expense (Benefit), Effective Income Tax Rate Reconciliation, Amount [Abstract] Vesting [Axis] Vesting [Axis] Lease Obligations Lessee, Finance Leases [Text Block] Entity [Domain] Entity [Domain] Net cash (used in) provided by investing activities Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member] Gain on sale of BioCryst Ireland Gain (Loss) on Disposition of Business Cash paid for interest Interest Paid, Excluding Capitalized Interest, Operating Activity Document Fiscal Year Focus Document Fiscal Year Focus Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Lender Name [Axis] Lender Name [Axis] Operating lease assets, net Operating Lease, Right-of-Use Asset Income tax expense at effective income tax rate Effective Income Tax Rate Reconciliation, Percent Reductions to prior period tax positions Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions Plan Name [Domain] Plan Name [Domain] Weighted average period for recognition (in years) Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Exercise of stock options, net (in shares) Exercised (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Valuation allowance Deferred Tax Assets, Valuation Allowance Equity [Abstract] Segment Information Segment Reporting Disclosure [Text Block] U.S. Federal Current Federal Tax Expense (Benefit) Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Compensation Actually Paid vs. Total Shareholder Return Compensation Actually Paid vs. Total Shareholder Return [Text Block] Leasing obligations Deferred Tax Assets Leasing Obligations Deferred Tax Assets Leasing Obligations Leases Lessee, Leases [Policy Text Block] Selling, general and administrative Selling, General and Administrative Expense Restricted cash Restricted Cash and Cash Equivalent, Current Acquisitions of property and equipment Payments to Acquire Productive Assets Depreciation and amortization Depreciation, Depletion and Amortization Finished goods Inventory, Finished Goods, Gross Statutory tax rate difference between Ireland and the United States Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Amount Total finance lease liabilities Total Finance Lease, Liability Arrangement Duration Trading Arrangement Duration Computer Equipment Computer Equipment [Member] Segments [Axis] Segments [Axis] Local Phone Number Local Phone Number Additional 402(v) Disclosure Additional 402(v) Disclosure [Text Block] Stock-Based Compensation Share-Based Payment Arrangement [Text Block] Clearside Biomedical, Inc. Clearside Biomedical, Inc. [Member] Clearside Biomedical, Inc. Debt instrument, commitment fee percentage Debt Instrument Commitment Fee Percentage Debt Instrument Commitment Fee Percentage Deferred tax liabilities: Deferred Tax Liabilities, Deferred Expense [Abstract] Assets Assets [Abstract] Reportable Segment Reportable Segment [Member] Reportable Segment Credit Facility [Axis] Credit Facility [Axis] Underlying Security Market Price Change Underlying Security Market Price Change, Percent Debt Instrument [Axis] Debt Instrument [Axis] Forfeited (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Employee 401(k) Plan Retirement Benefits [Text Block] Loss on extinguishment of debt Loss on extinguishment of debt Loss on extinguishment of debt Gain (Loss) on Extinguishment of Debt Royalty rate if maintains sakigake designation Royalty Rate If Maintains Sakigake Designation The percent of net sales that the company will receive if berotralstat maintains its Sakigake designation during the PMDA review. Credit Facility [Domain] Credit Facility [Domain] Stockholders’ deficit: Equity, Attributable to Parent [Abstract] Award vesting rights, percentage Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage Interest rate, stated percentage Debt Instrument, Interest Rate, Stated Percentage Operating lease liabilities Non-current operating lease liabilities Operating Lease, Liability, Noncurrent Entity Voluntary Filers Entity Voluntary Filers Inventory Accrued Inventory, Current Accrued Inventory, Current Accounts receivable, after allowance for credit loss, total Accounts Receivable, after Allowance for Credit Loss Property, Plant and Equipment [Abstract] Entity Registrant Name Entity Registrant Name Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal, Statement of Income or Comprehensive Income [Extensible Enumeration] Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal, Statement of Income or Comprehensive Income [Extensible Enumeration] Stock Price or TSR Estimation Method Stock Price or TSR Estimation Method [Text Block] Total assets measured at fair value Assets, Fair Value Disclosure Securities Debt Securities, Available-for-Sale, Unrealized Loss Position, Number of Positions Number of operating segments Number of Operating Segments Granted (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Percent [Abstract] Term Loans Term Loans [Member] Term Loans Restatement Determination Date: Restatement Determination Date [Axis] Foreign Deferred Foreign Income Tax Expense (Benefit) Schedule of Accrued Liability Activity Restructuring and Related Costs [Table Text Block] Interest expense, debt, total Interest Expense, Debt Name Trading Arrangement, Individual Name Maximum customary reduction on royalty rate Maximum Customary Reduction On Royalty Rate Maximum Customary Reduction On Royalty Rate Collaborative agreement contract value Collaborative Agreement Contract Value Collaborative Agreement Contract Value Debt instrument, face amount Debt Instrument, Face Amount Total equity consideration Business Combination, Consideration Transferred, Equity Interest Name Awards Close in Time to MNPI Disclosures, Individual Name Amounts paid during the year ended December 31, 2025 Payments for Restructuring Unvested, beginning balance (in usd per share) Unvested, ending balance (in usd per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Restructuring Type [Axis] Restructuring Type [Axis] Customary purchase price adjustments Disposal Group, Including Discontinued Operation, Customary Purchase Price Adjustments Disposal Group, Including Discontinued Operation, Customary Purchase Price Adjustments Aggregate Erroneous Compensation Not Yet Determined Aggregate Erroneous Compensation Not Yet Determined [Text Block] ICFR Auditor Attestation Flag ICFR Auditor Attestation Flag Maximum number of shares per employee (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Number of Shares Per Employee Stock-based compensation expense APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Schedule of Maturities of Finance Lease Liabilities Finance Lease, Liability, to be Paid, Maturity [Table Text Block] Vested and expected to vest at December 31, 2025 Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Foreign Foreign Tax Jurisdiction [Member] Auditor Firm ID Auditor Firm ID Segments [Domain] Segments [Domain] The 2021 RPI Royalty Purchase Agreement The 2021 RPI Royalty Purchase Agreement [Member] The 2021 RPI Royalty Purchase Agreement Statement of Income Location, Balance [Axis] Statement of Income Location, Balance [Axis] Foreign Income (Loss) from Continuing Operations before Income Taxes, Foreign Deferred tax assets: Deferred Tax Assets, Tax Deferred Expense [Abstract] Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Increase in inventory Increase (Decrease) in Inventories Annual Net Sales Range [Axis] Annual Net Sales Range [Axis] Annual Net Sales Range Term Loan Tranche D Term Loan Tranche D [Member] Term Loan Tranche D 2020 RPI Royalty Agreement 2020 RPI Royalty Agreement [Member] Twenty Twenty RPI Royalty Agreement Less accumulated depreciation and amortization Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Net Income (Loss) Per Share Earnings Per Share, Policy [Policy Text Block] Advance Royalties [Abstract] Annual Net Sales Under $150,000 Annual Net Sales Under $150,000 [Member] Annual Net Sales Under $150,000 Revenue Recognition Revenue [Policy Text Block] Common stock issued to directors in lieu of cash retainer Proceeds From Issuance Of Common Stock, Issued For Services Proceeds From Issuance Of Common Stock, Issued For Services Purchases of investments Payments to Acquire Debt Securities, Available-for-Sale Preferred stock, $0.01 par value; shares authorized - 5,000; no shares issued and outstanding at December 31, 2025 and 2024 Preferred Stock, Value, Issued All Executive Categories All Executive Categories [Member] Total stock-based compensation costs Share-Based Payment Arrangement, Expensed and Capitalized, Amount Schedule of Deferred Tax Assets And Liabilities Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Common stock, $0.01 par value; shares authorized - 450,000; shares issued and outstanding – 213,060 and 208,543 at December 31, 2025 and 2024, respectively Common Stock, Value, Issued Finance lease assets, net Finance Lease, Right-of-Use Asset, after Accumulated Amortization Short-term investments Short-Term Investments Title and Position [Axis] Title and Position [Axis] Business Combination [Axis] Business Combination [Axis] Loan Agreement Loans Payable [Member] Net deferred tax assets Deferred Tax Assets, Net Reclassification of equity awards to share-based liability Adjustments to Additional Paid-in Capital, Reclassification Of Reclassification of Equity Awards To Share-Based Liability Adjustments to Additional Paid-in Capital, Reclassification Of Reclassification of Equity Awards To Share-Based Liability PEO Actually Paid Compensation Amount PEO Actually Paid Compensation Amount Maximum number of shares per employee, amount ShareBasedCompensationArrangementBySharebasedPaymentAwardMaximumNumberOfSharesPerEmployeeAmount ShareBasedCompensationArrangementBySharebasedPaymentAwardMaximumNumberOfSharesPerEmployeeAmount Cancelled or Forfeited (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period Amortization of discount on investments, net Amortization Of Premium/Discount On Investments Amortization Of Premium/Discount On Investments Long-term investment maturity, minimum (in months) Longterm Investment Maturity Minimum Longterm Investment Maturity Minimum Fair value disclosure Debt Instrument, Fair Value Disclosure Schedule of Unrecognized Tax Benefits Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] Astria Astria [Member] Astria Senior Credit Facility Senior Credit Facility [Member] Senior Credit Facility Maturity period of high quality marketable securities (in years) Maturity Period Of High Quality Marketable Securities Maturity Period Of High Quality Marketable Securities California CALIFORNIA Sale of non-financial asset Proceeds from Sale of Other Assets, Investing Activities All Individuals All Individuals [Member] Long-term Debt, Type [Domain] Long-Term Debt, Type [Domain] Increase in receivables Increase (Decrease) in Receivables Name Forgone Recovery, Individual Name Expiration period (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member] Accrued expenses Disposal Group, Including Discontinued Operation, Accrued Liabilities, Current Disposal Group Classification [Axis] Disposal Group Classification [Axis] Net proceeds from common stock issued under stock-based compensation plans Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised Reconciliation of cash, cash equivalents and restricted cash: Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation [Abstract] U.S. Geographic Distribution, Domestic [Member] Term Loan Tranche A Term Loan Tranche A [Member] Term Loan Tranche A Other State Tax Jurisdiction, Other [Member] State Tax Jurisdiction, Other Mark-to-market adjustment on share-based liability Fair Value Adjustment, Share-Based Liability Fair Value Adjustment, Share-Based Liability Erroneous Compensation Analysis Erroneous Compensation Analysis [Text Block] Royalties Monetizations [Line Items] Royalties Monetizations [Line Items] Royalties Monetizations Lessee, Lease, Description [Line Items] Lessee, Lease, Description [Line Items] Rule 10b5-1 Arrangement Terminated Rule 10b5-1 Arrangement Terminated [Flag] Adjustments and reconciling items Segment Reporting, Adjustments and Reconciling Items, Amount Segment Reporting, Adjustments and Reconciling Items, Amount Foreign currency losses, net Gain (Loss), Foreign Currency Transaction, before Tax Royalty purchase agreement, royalties, percentage of annual net sales in other markets Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales In Other Markets Royalty Purchase Agreement Royalties Percentage Of Annual Net Sales In Other Markets Erroneously Awarded Compensation Recovery Erroneously Awarded Compensation Recovery [Table] Interest income Interest Income, Operating Concentration Risk Benchmark [Domain] Concentration Risk Benchmark [Domain] Title of 12(b) Security Title of 12(b) Security Lessee, Lease, Description [Table] Lessee, Lease, Description [Table] Disposal Groups, Including Discontinued Operations [Table] Disposal Groups, Including Discontinued Operations [Table] Non-cash interest expense on royalty financing obligations Non Cash Interest Expense On Royalty Financing Liabilities Non Cash Interest Expense On Royalty Financing Liabilities Paid-in-kind interest Paid-in-Kind Interest Earnings Per Share [Abstract] 2030 Lessee, Operating Lease, Liability, to be Paid, Year Five Total other expense, net Nonoperating Income (Expense) Prepayment premiums Debt Instrument, Prepayment Premium Debt Instrument, Prepayment Premium Schedule of Potential Shares Excluded from Computation of Diluted Net Income (Loss) Per Share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Tax credit carryforward, amount Tax Credit Carryforward, Amount Decrease in deferred revenue Increase (Decrease) in Contract with Customer, Liability Number of optional ordering periods Number of Optional Ordering Periods Number of Optional Ordering Periods RPI 2021 and 2020 Intermediate Finance Trust RPI 2021 And 2020 Intermediate Finance Trust [Member] RPI 2021 And 2020 Intermediate Finance Trust Thereafter Finance Lease, Liability, to be Paid, after Year Five Exercised (in usd per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Award Timing Disclosures [Line Items] Schedule of Inventories Schedule of Inventory, Current [Table Text Block] RPI 2019 Intermediate Finance Trust RPI 2019 Intermediate Finance Trust [Member] RPI 2019 Intermediate Finance Trust Potential milestone payments receivable if regulatory approval before specified date Potential Milestone Payments Receivable If Regulatory Approval Before Milestone The amount of potential milestone payments receivable if regulatory approval is granted. Term Loan Tranche B Term Loan Tranche B [Member] Term Loan Tranche B Stockholders' Equity Equity [Text Block] Contract term (in years/months) ContractTerm ContractTerm State Deferred State and Local Income Tax Expense (Benefit) Net income (loss) Net income (loss) Consolidated net income (loss) Net Income (Loss) Attributable to Parent Subsequent Event [Table] Subsequent Event [Table] Operating lease liabilities: Operating Lease, Liability [Abstract] Other non-program specific and indirect costs Other Expenses 1 [Member] Other Expenses 1 Laboratory Equipment, Office Equipment and Software Laboratory Equipment Office Equipment And Software [Member] Laboratory Equipment Office Equipment And Software Construction in progress Construction in Progress [Member] Other Other Accrued Liabilities, Current Schedule of Differences Between Effective Tax Rate and Statutory Tax Rate Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Award vesting period (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period Other Effective Income Tax Rate Reconciliation, Other Adjustments, Percent Segment Reporting Information [Line Items] Segment Reporting Information [Line Items] Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Adoption Date Trading Arrangement Adoption Date One-time Termination Benefits One-time Termination Benefits [Member] Lessee, operating lease, term of contract (in years) Lessee, Operating Lease, Term of Contract Selling, General and Administrative Expenses Selling, General and Administrative Expenses, Policy [Policy Text Block] Income (loss) from operations Operating Income (Loss) Line of Credit Line of Credit [Member] Accumulated deficit Retained Earnings (Accumulated Deficit) License agreement, upfront payment License Agreement, Upfront Payment License Agreement, Upfront Payment Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member] Exercise of warrants Stock Issued During Period, Value, Exercise of Warrants Stock Issued During Period, Value, Exercise of Warrants Royalty financing obligations Royalty Financing Liabilities, Noncurrent Royalty Financing Liabilities, Noncurrent Incremental stock-based compensation expense Share-Based Payment Arrangement, Plan Modification, Incremental Cost Cumulative translation adjustments upon deconsolidation Disposal Group, Including Discontinued Operation, Foreign Currency Translation Gains (Losses) Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member] Maturing after one year through two years Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date After One Year and Before Two Years Amount of investment in debt securities maturing after one year through two years. Statement [Table] Statement [Table] Total deferred expense provision Deferred Income Tax Expense (Benefit) Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract] Cash flows from financing activities: Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] Revenue Revenue Benchmark [Member] Other Other foreign jurisdictions Foreign Tax Jurisdiction, Other [Member] Finance lease liabilities Non-current finance lease liabilities Finance Lease, Liability, Noncurrent All Adjustments to Compensation All Adjustments to Compensation [Member] Amendment Flag Amendment Flag Number of shares authorized (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized Accrued Interest Debt Securities, Available-for-Sale, Accrued Interest, after Allowance for Credit Loss Software Software Development [Member] Termination Date Trading Arrangement Termination Date Insider Trading Policies and Procedures Adopted Insider Trading Policies and Procedures Adopted [Flag] Schedule of Royalty Financing Obligations Royalty Financing Liabilities [Table Text Block] Royalty Financing Liabilities Blackstone Blackstone [Member] Blackstone Receivable [Domain] Receivable [Domain] Operating leases Operating Lease, Weighted Average Discount Rate, Percent Provisions and accruals for interest and penalties Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued Weighted average shares of common stock outstanding: basic (in shares) Weighted Average Number of Shares Outstanding, Basic Inventory obsolescence Inventory Write-down Total restricted cash Restricted Cash and Cash Equivalent, Noncurrent Exercisable (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number Subsequent Events [Abstract] Segment Reporting [Abstract] Operating lease expense Operating Lease, Expense Deferred debt fees and issuance costs Deferred Debt Fees And Issuance Costs Deferred Debt Fees And Issuance Costs Debt Disclosure [Abstract] Expenses: Costs and Expenses [Abstract] Restructuring and Related Activities [Abstract] Forgone Recovery due to Expense of Enforcement, Amount Forgone Recovery due to Expense of Enforcement, Amount Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Common stock, par or stated value (in usd per share) Common Stock, Par or Stated Value Per Share Geographic Distribution [Axis] Geographic Distribution [Axis] Granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Trade receivables Disposal Group, Including Discontinued Operation, Accounts, Notes and Loans Receivable, Net Use of Estimates Use of Estimates, Policy [Policy Text Block] Operating cash flows for finance leases Finance Lease, Interest Payment on Liability Weighted average purchase price of shares purchased (in usd per share) Employee Stock Ownership Plan (ESOP), Weighted Average Purchase Price of Shares Purchased Subsequent Events Subsequent Events [Text Block] Insider Trading Arrangements [Line Items] Vest 25% Each Year Until Fully Vested Vest 25 Percent Each Year Until Fully Vested [Member] Vest 25 Percent Each Year Until Fully Vested Schedule of Finance Lease Assets and Liabilities Lessee, Finance Lease, Assets and Liabilities [Table Text Block] Lessee, Finance Lease, Assets and Liabilities Research, discovery and preclinical programs Research, Discovery And Preclinical Programs [Member] Research, Discovery And Preclinical Programs Raw materials Inventory, Raw Materials, Gross Total liabilities Liabilities Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Axis] Product Product Concentration Risk [Member] 2030 Finance Lease, Liability, to be Paid, Year Five Pension Adjustments Prior Service Cost Pension Adjustments Prior Service Cost [Member] Additions to current period tax positions Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions Sales and maturities of investments Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Counterparty Name [Axis] Counterparty Name [Axis] Obligations of U.S. Government and its agencies Estimated Fair Value Total investments Debt Securities, Available-for-Sale Tax Credit Carryforward, Name [Domain] Tax Credit Carryforward, Name [Domain] Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Non-NEOs Non-NEOs [Member] Royalty rate if maintains sakigake designation Royalty Rate Royalty Rate Between the Second and Third Anniversaries Between The Second And Third Anniversaries [Member] Between The Second And Third Anniversaries