0000001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Stockholders' Deficit link:presentationLink link:calculationLink link:definitionLink 9952156 - Disclosure - Significant Accounting Policies and Concentrations of Risk link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Divestiture of BioCryst Ireland Limited link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Revenue link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Fair Value Measurements and Investments link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Trade Receivables link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Inventory link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Property and Equipment link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Accrued Expenses link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Royalty Financing Obligations link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Lease Obligations link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Employee 401(k) Plan link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Collaborative and Other Relationships link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Workforce Reduction link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Segment Information link:presentationLink link:calculationLink link:definitionLink 9952174 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952175 - Disclosure - Net Income (Loss) Per Share link:presentationLink link:calculationLink link:definitionLink 9952176 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Significant Accounting Policies and Concentrations of Risk (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Significant Accounting Policies and Concentrations of Risk (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Divestiture of BioCryst Ireland Limited (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Revenue (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Fair Value Measurements and Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Inventory (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Property and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Accrued Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Royalty Financing Obligations (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Lease Obligations (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Workforce Reduction (Tables) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Segment Information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Net Income (Loss) Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Significant Accounting Policies and Concentrations of Risk - Schedule of Revenues (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Significant Accounting Policies and Concentrations of Risk - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Divestiture of BioCryst Ireland Limited - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Divestiture of BioCryst Ireland Limited - Schedule of Major Classes of Assets and Liabilities Sold (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Fair Value Measurements and Investments - Schedule of Assets Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Fair Value Measurements and Investments - Schedule of Investments By Type (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Fair Value Measurements and Investments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Fair Value Measurements and Investments - Schedule of Maturity of Investments (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Trade Receivables (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Inventory (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Property and Equipment - Schedule of Property and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Property and Equipment - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Royalty Financing Obligations - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Royalty Financing Obligations - Schedule of Royalty Financing Obligations (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Lease Obligations - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Lease Obligations - Schedule of Lease Expense Under Operating and Finance Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Lease Obligations - Schedule of Other Supplemental Information Related to Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Lease Obligations - Schedule of Operating Lease and Finance Lease Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Lease Obligations - Schedule of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Lease Obligations - Schedule of Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Lease Obligations - Schedule of Supplemental Cash Flow Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Stockholders' Equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Stockholders' Equity - Schedule of Shares Reserved for Future Issuance of Common Stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Stock-Based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - 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Income Taxes - Schedule of Income Taxes Paid, Net of Refunds Received (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Income Taxes - Schedule of Differences Between Effective Tax Rate and Statutory Tax Rate (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Income Taxes - Schedule of Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Income Taxes - Schedule of Deferred Tax Assets And Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Employee 401(k) Plan (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Collaborative and Other Relationships (Details) link:presentationLink link:calculationLink link:definitionLink 9955567 - Disclosure - Workforce Reduction - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955568 - Disclosure - Workforce Reduction - Schedule of Accrued Liability Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955569 - Disclosure - Segment Information - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955570 - Disclosure - Segment Information - Schedule of Segment Reporting Information, by Segment (Details) link:presentationLink link:calculationLink link:definitionLink 9955571 - Disclosure - Net Income (Loss) Per Share - Schedule of Basic and Diluted Net Income (Loss) Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955572 - Disclosure - Net Income (Loss) Per Share - Schedule of Potential Shares Excluded from Computation of Diluted Net Income (Loss) Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955573 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink