corresp
 

(BIOCRYST LOGO)
BIOCRYST PHARMACEUTICALS, INC.
2190 Parkway Lake Drive
Birmingham, AL 35244
December 8, 2006
Via EDGAR
Mr. Jim B. Rosenberg
Senior Assistant Chief Accountant
Division of Corporation Finance
U.S. Securities and Exchange Commission
100 F Street, N.E.
Washington, D. C. 20549-6010
     
Re:
  BioCryst Pharmaceuticals, Inc.
 
  Form 10-K for the Fiscal Year Ended December 31, 2005
 
  Filed March 9, 2006
 
  File No. 000-23186
Dear Mr. Rosenberg:
     In connection with the letter from the Staff of the Securities and Exchange Commission (the “Staff”) dated November 15, 2006 to Charles E. Bugg, Ph.D., Chairman and Chief Executive Officer of BioCryst Pharmaceuticals, Inc. (“the Company”), which the Company received on December 4, 2006 (the “Comment Letter”), and as you requested in a telephone conversation with the undersigned earlier today, the Company hereby advises the Staff that it will provide the responses and supplemental information requested in the Comment Letter to the Staff no later than December 15, 2006.
         
  Very truly yours,
 
 
  /s/ Michael A. Darwin    
     
  Michael A. Darwin   
 
     
cc:
  Kei Ino
 
  Jim Atkinson
 
  Charles E. Bugg, Ph.D.